Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss
Abstract INTRODUCTION Age‐related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia risk in subjects with normal hearing or mild hearing loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as a...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-01-01
|
| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12467 |
| _version_ | 1827307472785768448 |
|---|---|
| author | Vicente Medel Paul H. Delano Chama Belkhiria Alexis Leiva Cristina De Gatica Victor Vidal Carlos F. Navarro Simon San Martín Melissa Martínez Christine Gierke Ximena García Mauricio Cerda Rodrigo Vergara Carolina Delgado Gonzalo A. Farías |
| author_facet | Vicente Medel Paul H. Delano Chama Belkhiria Alexis Leiva Cristina De Gatica Victor Vidal Carlos F. Navarro Simon San Martín Melissa Martínez Christine Gierke Ximena García Mauricio Cerda Rodrigo Vergara Carolina Delgado Gonzalo A. Farías |
| author_sort | Vicente Medel |
| collection | DOAJ |
| description | Abstract INTRODUCTION Age‐related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia risk in subjects with normal hearing or mild hearing loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as an objective and sensitive tool to estimate the risk of cognitive decline in older adults with normal hearing or mild hearing loss. METHODS We assessed neuropsychological, brain magnetic resonance imaging, and auditory analyses on 94 subjects > 64 years of age. RESULTS We found that cochlear dysfunction, measured by DPOAEs—and not by conventional audiometry—was associated with Clinical Dementia Rating Sum of Boxes (CDR‐SoB) classification and brain atrophy in the group with mild hearing loss (25 to 40 dB) and normal hearing (<25 dB). DISCUSSION Our findings suggest that DPOAEs may be a non‐invasive tool for detecting neurodegeneration and cognitive decline in the older adults, potentially allowing for early intervention. |
| first_indexed | 2024-04-24T18:40:45Z |
| format | Article |
| id | doaj.art-2e50552b62ae49329a8b2a4a81d5a747 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-04-24T18:40:45Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-2e50552b62ae49329a8b2a4a81d5a7472024-03-27T13:14:40ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292024-01-01161n/an/a10.1002/dad2.12467Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing lossVicente Medel0Paul H. Delano1Chama Belkhiria2Alexis Leiva3Cristina De Gatica4Victor Vidal5Carlos F. Navarro6Simon San Martín7Melissa Martínez8Christine Gierke9Ximena García10Mauricio Cerda11Rodrigo Vergara12Carolina Delgado13Gonzalo A. Farías14Departamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileBiomedical Neuroscience Institute (BNI) Facultad de Medicina Universidad de Chile Santiago ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileServicio Neurología y Neurocirugía Hospital Clínico de la Universidad de Chile Santiago ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileBiomedical Neuroscience Institute (BNI) Facultad de Medicina Universidad de Chile Santiago ChileFacultad de Psicología y Humanidades Universidad San Sebastián Sede Valdivia ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileDepartamento de Neurociencia Facultad de Medicina Universidad de Chile Santiago ChileAbstract INTRODUCTION Age‐related hearing loss is an important risk factor for cognitive decline. However, audiogram thresholds are not good estimators of dementia risk in subjects with normal hearing or mild hearing loss. Here we propose to use distortion product otoacoustic emissions (DPOAEs) as an objective and sensitive tool to estimate the risk of cognitive decline in older adults with normal hearing or mild hearing loss. METHODS We assessed neuropsychological, brain magnetic resonance imaging, and auditory analyses on 94 subjects > 64 years of age. RESULTS We found that cochlear dysfunction, measured by DPOAEs—and not by conventional audiometry—was associated with Clinical Dementia Rating Sum of Boxes (CDR‐SoB) classification and brain atrophy in the group with mild hearing loss (25 to 40 dB) and normal hearing (<25 dB). DISCUSSION Our findings suggest that DPOAEs may be a non‐invasive tool for detecting neurodegeneration and cognitive decline in the older adults, potentially allowing for early intervention.https://doi.org/10.1002/dad2.12467agingbiomarkerbrain atrophycognitive declineDPOAEpresbycusis |
| spellingShingle | Vicente Medel Paul H. Delano Chama Belkhiria Alexis Leiva Cristina De Gatica Victor Vidal Carlos F. Navarro Simon San Martín Melissa Martínez Christine Gierke Ximena García Mauricio Cerda Rodrigo Vergara Carolina Delgado Gonzalo A. Farías Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring aging biomarker brain atrophy cognitive decline DPOAE presbycusis |
| title | Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss |
| title_full | Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss |
| title_fullStr | Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss |
| title_full_unstemmed | Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss |
| title_short | Cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss |
| title_sort | cochlear dysfunction as an early biomarker of cognitive decline in normal hearing and mild hearing loss |
| topic | aging biomarker brain atrophy cognitive decline DPOAE presbycusis |
| url | https://doi.org/10.1002/dad2.12467 |
| work_keys_str_mv | AT vicentemedel cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT paulhdelano cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT chamabelkhiria cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT alexisleiva cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT cristinadegatica cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT victorvidal cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT carlosfnavarro cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT simonsanmartin cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT melissamartinez cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT christinegierke cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT ximenagarcia cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT mauriciocerda cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT rodrigovergara cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT carolinadelgado cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss AT gonzaloafarias cochleardysfunctionasanearlybiomarkerofcognitivedeclineinnormalhearingandmildhearingloss |