STATINS PROTECTIVE ROLE IN PATIENTS WITH CHRONIC TOTAL OCCLUSIONS OF CORONARY ARTERIES IN INTRACORONARY INTERVENTIONS
The article is devoted to the current state of the problem of statin use in interventional cardiology. It is shown that the use of statins in patients with stable manifestations of coronary heart disease, and in patients with acute coronary syndrome has a protective effect, which is reflected in the...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics
2017-03-01
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| Series: | Атеросклероз |
| Subjects: | |
| Online Access: | https://ateroskleroz.elpub.ru/jour/article/view/37/37 |
| _version_ | 1797963765470199808 |
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| author | A. S. Ragozina I. V. Petrenko I. A. Urvantseva K. Yu. Nikolaev |
| author_facet | A. S. Ragozina I. V. Petrenko I. A. Urvantseva K. Yu. Nikolaev |
| author_sort | A. S. Ragozina |
| collection | DOAJ |
| description | The article is devoted to the current state of the problem of statin use in interventional cardiology. It is shown that the use of statins in patients with stable manifestations of coronary heart disease, and in patients with acute coronary syndrome has a protective effect, which is reflected in the reduction of perioperative myocardial ischemia, improvement of left ventricular systolic function, reducing the number of adverse cardiac events. It is known that the protective role of statins is associated not only with the cholesterol-lowering effect, but also with a large number of pleiotropic effects. A lot of attention is paid to the complex and problematic group of patients with chronic total occlusions of coronary arteries (CTO). The presence of CTO is associated with poor prognosis and increased mortality in long-term period. A significant problem during percutaneous coronary intervention (PCI) in patients with the CTO is a frequent development of perioperative ischemia or myocardial infarction, which is associated with an increased mortality rates within 30 days after PCI, as well as in the long-term period. Currently, mostly proved protective effect of atorvastatin. Based on the analysis of contemporary literature is concluded that statin efficacy in the prevention of complications of PCI in patients with CTO is currently not in doubt. |
| first_indexed | 2024-04-11T01:33:22Z |
| format | Article |
| id | doaj.art-2e50b9c167b3415599bd71d1757a2637 |
| institution | Directory Open Access Journal |
| issn | 2078-256X |
| language | Russian |
| last_indexed | 2024-04-11T01:33:22Z |
| publishDate | 2017-03-01 |
| publisher | Siberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and Genetics |
| record_format | Article |
| series | Атеросклероз |
| spelling | doaj.art-2e50b9c167b3415599bd71d1757a26372023-01-03T09:14:40ZrusSiberian Branch of Russian Academy of Sciences, Research Institute of Internal and Preventive Medicine, branch of the Institute of Cytology and GeneticsАтеросклероз2078-256X2017-03-011313540STATINS PROTECTIVE ROLE IN PATIENTS WITH CHRONIC TOTAL OCCLUSIONS OF CORONARY ARTERIES IN INTRACORONARY INTERVENTIONSA. S. Ragozina0I. V. Petrenko1I. A. Urvantseva2K. Yu. Nikolaev3State-Financed Organization Khanty-Mansi Autonomous Region - Ugra “District Cardiodispensary “Centre of Diagnosis and Cardiovascular Surgery” Russian FederationState-Financed Organization Khanty-Mansi Autonomous Region - Ugra “District Cardiodispensary “Centre of Diagnosis and Cardiovascular Surgery” Russian FederationState-Financed Organization Khanty-Mansi Autonomous Region - Ugra “District Cardiodispensary “Centre of Diagnosis and Cardiovascular Surgery” Russian FederationInstitute of Internal and Preventive Medicine Russian FederationThe article is devoted to the current state of the problem of statin use in interventional cardiology. It is shown that the use of statins in patients with stable manifestations of coronary heart disease, and in patients with acute coronary syndrome has a protective effect, which is reflected in the reduction of perioperative myocardial ischemia, improvement of left ventricular systolic function, reducing the number of adverse cardiac events. It is known that the protective role of statins is associated not only with the cholesterol-lowering effect, but also with a large number of pleiotropic effects. A lot of attention is paid to the complex and problematic group of patients with chronic total occlusions of coronary arteries (CTO). The presence of CTO is associated with poor prognosis and increased mortality in long-term period. A significant problem during percutaneous coronary intervention (PCI) in patients with the CTO is a frequent development of perioperative ischemia or myocardial infarction, which is associated with an increased mortality rates within 30 days after PCI, as well as in the long-term period. Currently, mostly proved protective effect of atorvastatin. Based on the analysis of contemporary literature is concluded that statin efficacy in the prevention of complications of PCI in patients with CTO is currently not in doubt.https://ateroskleroz.elpub.ru/jour/article/view/37/37chronic total occlusion of coronary arteriesatorvastatinrecanalizationpercutaneous coronary intervention |
| spellingShingle | A. S. Ragozina I. V. Petrenko I. A. Urvantseva K. Yu. Nikolaev STATINS PROTECTIVE ROLE IN PATIENTS WITH CHRONIC TOTAL OCCLUSIONS OF CORONARY ARTERIES IN INTRACORONARY INTERVENTIONS Атеросклероз chronic total occlusion of coronary arteries atorvastatin recanalization percutaneous coronary intervention |
| title | STATINS PROTECTIVE ROLE IN PATIENTS WITH CHRONIC TOTAL OCCLUSIONS OF CORONARY ARTERIES IN INTRACORONARY INTERVENTIONS |
| title_full | STATINS PROTECTIVE ROLE IN PATIENTS WITH CHRONIC TOTAL OCCLUSIONS OF CORONARY ARTERIES IN INTRACORONARY INTERVENTIONS |
| title_fullStr | STATINS PROTECTIVE ROLE IN PATIENTS WITH CHRONIC TOTAL OCCLUSIONS OF CORONARY ARTERIES IN INTRACORONARY INTERVENTIONS |
| title_full_unstemmed | STATINS PROTECTIVE ROLE IN PATIENTS WITH CHRONIC TOTAL OCCLUSIONS OF CORONARY ARTERIES IN INTRACORONARY INTERVENTIONS |
| title_short | STATINS PROTECTIVE ROLE IN PATIENTS WITH CHRONIC TOTAL OCCLUSIONS OF CORONARY ARTERIES IN INTRACORONARY INTERVENTIONS |
| title_sort | statins protective role in patients with chronic total occlusions of coronary arteries in intracoronary interventions |
| topic | chronic total occlusion of coronary arteries atorvastatin recanalization percutaneous coronary intervention |
| url | https://ateroskleroz.elpub.ru/jour/article/view/37/37 |
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