Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseases
MicroRNAs (miRNA) are small non-coding RNA molecules that regulate posttranscriptional gene expression by repressing messengerRNA-targets. MiRNAs are abundant in many cell types and are secreted into extracellular fluids, protected from degradation by packaging in extracellular vesicles. These circu...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1168898/full |
| _version_ | 1797821407552339968 |
|---|---|
| author | Julika Huber Julika Huber Julika Huber Julika Huber Michael T. Longaker Michael T. Longaker Michael T. Longaker Michael T. Longaker Natalina Quarto Natalina Quarto Natalina Quarto |
| author_facet | Julika Huber Julika Huber Julika Huber Julika Huber Michael T. Longaker Michael T. Longaker Michael T. Longaker Michael T. Longaker Natalina Quarto Natalina Quarto Natalina Quarto |
| author_sort | Julika Huber |
| collection | DOAJ |
| description | MicroRNAs (miRNA) are small non-coding RNA molecules that regulate posttranscriptional gene expression by repressing messengerRNA-targets. MiRNAs are abundant in many cell types and are secreted into extracellular fluids, protected from degradation by packaging in extracellular vesicles. These circulating miRNAs are easily accessible, disease-specific and sensitive to small changes, which makes them ideal biomarkers for diagnostic, prognostic, predictive or monitoring purposes. Specific miRNA signatures can be reflective of disease status and development or indicators of poor treatment response. This is especially important in malignant diseases, as the ease of accessibility of circulating miRNAs circumvents the need for invasive tissue biopsy. In osteogenesis, miRNAs can act either osteo-enhancing or osteo-repressing by targeting key transcription factors and signaling pathways. This review highlights the role of circulating and extracellular vesicle-derived miRNAs as biomarkers in bone-related diseases, with a specific focus on osteoporosis and osteosarcoma. To this end, a comprehensive literature search has been performed. The first part of the review discusses the history and biology of miRNAs, followed by a description of different types of biomarkers and an update of the current knowledge of miRNAs as biomarkers in bone related diseases. Finally, limitations of miRNAs biomarker research and future perspectives will be presented. |
| first_indexed | 2024-03-13T09:52:16Z |
| format | Article |
| id | doaj.art-2e53f798bf6b4ad79f688034db5cf189 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-13T09:52:16Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-2e53f798bf6b4ad79f688034db5cf1892023-05-24T06:10:35ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11688981168898Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseasesJulika Huber0Julika Huber1Julika Huber2Julika Huber3Michael T. Longaker4Michael T. Longaker5Michael T. Longaker6Michael T. Longaker7Natalina Quarto8Natalina Quarto9Natalina Quarto10Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United StatesDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Plastic Surgery, University Hospital Bergmannsheil Bochum, Bochum, GermanyHagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United StatesDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, United StatesInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United StatesHagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United StatesDivision of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, United StatesDepartment of Surgery, Stanford University School of Medicine, Stanford, CA, United StatesMicroRNAs (miRNA) are small non-coding RNA molecules that regulate posttranscriptional gene expression by repressing messengerRNA-targets. MiRNAs are abundant in many cell types and are secreted into extracellular fluids, protected from degradation by packaging in extracellular vesicles. These circulating miRNAs are easily accessible, disease-specific and sensitive to small changes, which makes them ideal biomarkers for diagnostic, prognostic, predictive or monitoring purposes. Specific miRNA signatures can be reflective of disease status and development or indicators of poor treatment response. This is especially important in malignant diseases, as the ease of accessibility of circulating miRNAs circumvents the need for invasive tissue biopsy. In osteogenesis, miRNAs can act either osteo-enhancing or osteo-repressing by targeting key transcription factors and signaling pathways. This review highlights the role of circulating and extracellular vesicle-derived miRNAs as biomarkers in bone-related diseases, with a specific focus on osteoporosis and osteosarcoma. To this end, a comprehensive literature search has been performed. The first part of the review discusses the history and biology of miRNAs, followed by a description of different types of biomarkers and an update of the current knowledge of miRNAs as biomarkers in bone related diseases. Finally, limitations of miRNAs biomarker research and future perspectives will be presented.https://www.frontiersin.org/articles/10.3389/fendo.2023.1168898/fullmicroRNAbiomarkerboneosteosarcomaosteoporosisextracellular vesicles |
| spellingShingle | Julika Huber Julika Huber Julika Huber Julika Huber Michael T. Longaker Michael T. Longaker Michael T. Longaker Michael T. Longaker Natalina Quarto Natalina Quarto Natalina Quarto Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseases Frontiers in Endocrinology microRNA biomarker bone osteosarcoma osteoporosis extracellular vesicles |
| title | Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseases |
| title_full | Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseases |
| title_fullStr | Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseases |
| title_full_unstemmed | Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseases |
| title_short | Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseases |
| title_sort | circulating and extracellular vesicle derived micrornas as biomarkers in bone related diseases |
| topic | microRNA biomarker bone osteosarcoma osteoporosis extracellular vesicles |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1168898/full |
| work_keys_str_mv | AT julikahuber circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT julikahuber circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT julikahuber circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT julikahuber circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT michaeltlongaker circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT michaeltlongaker circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT michaeltlongaker circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT michaeltlongaker circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT natalinaquarto circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT natalinaquarto circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases AT natalinaquarto circulatingandextracellularvesiclederivedmicrornasasbiomarkersinbonerelateddiseases |