Numerical simulation of inertial microfluidics: a review
Since the proposal of inertial microfluidics in 2007, it has been widely used for particle focusing and separation with superior performances. The particle migration behaviour in microchannel is extremely complicated involving various parameters. Recently, computational approaches have been utilized...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Engineering Applications of Computational Fluid Mechanics |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19942060.2023.2177350 |
| _version_ | 1797403891724189696 |
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| author | Ruiju Shi |
| author_facet | Ruiju Shi |
| author_sort | Ruiju Shi |
| collection | DOAJ |
| description | Since the proposal of inertial microfluidics in 2007, it has been widely used for particle focusing and separation with superior performances. The particle migration behaviour in microchannel is extremely complicated involving various parameters. Recently, computational approaches have been utilized to obtain better insights into the underlying physics, which facilitates a comprehensive and intuitive understanding of particle migration in inertial flow. The numerical methods are ideal ways for assessing the effects of various parameters on particle focusing. In this review, numerous theories and models proposed to systematically explore the effects on migration of particles are summed concisely, especially numerical methods. Besides, latest research advances in direct numerical simulation of diverse particle motion and migration, whether rigid or deformable, spherical or non-spherical, suspended in simple or complex channel, are introduced comprehensively. Then, numerical simulations for microfluidic devices design are provided and discussed to facilitate the optimization of microchannel and the design of coupling microfluidic device for real- particles separation. Finally, we further discuss the remaining challenges in the modeling of inertial particle microfluidics and provide several suggestions for future investigators. |
| first_indexed | 2024-03-09T02:46:06Z |
| format | Article |
| id | doaj.art-2e55060e5ff84352a5bb0952377fe26c |
| institution | Directory Open Access Journal |
| issn | 1994-2060 1997-003X |
| language | English |
| last_indexed | 2024-03-09T02:46:06Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Engineering Applications of Computational Fluid Mechanics |
| spelling | doaj.art-2e55060e5ff84352a5bb0952377fe26c2023-12-05T16:53:44ZengTaylor & Francis GroupEngineering Applications of Computational Fluid Mechanics1994-20601997-003X2023-12-0117110.1080/19942060.2023.2177350Numerical simulation of inertial microfluidics: a reviewRuiju Shi0Jihua Institute of Biomedical Engineering and Technology, Ji Hua Laboratory, Foshan City, People’s Republic of ChinaSince the proposal of inertial microfluidics in 2007, it has been widely used for particle focusing and separation with superior performances. The particle migration behaviour in microchannel is extremely complicated involving various parameters. Recently, computational approaches have been utilized to obtain better insights into the underlying physics, which facilitates a comprehensive and intuitive understanding of particle migration in inertial flow. The numerical methods are ideal ways for assessing the effects of various parameters on particle focusing. In this review, numerous theories and models proposed to systematically explore the effects on migration of particles are summed concisely, especially numerical methods. Besides, latest research advances in direct numerical simulation of diverse particle motion and migration, whether rigid or deformable, spherical or non-spherical, suspended in simple or complex channel, are introduced comprehensively. Then, numerical simulations for microfluidic devices design are provided and discussed to facilitate the optimization of microchannel and the design of coupling microfluidic device for real- particles separation. Finally, we further discuss the remaining challenges in the modeling of inertial particle microfluidics and provide several suggestions for future investigators.https://www.tandfonline.com/doi/10.1080/19942060.2023.2177350Inertial microfluidicsdirect numerical simulationcell separationCTCs |
| spellingShingle | Ruiju Shi Numerical simulation of inertial microfluidics: a review Engineering Applications of Computational Fluid Mechanics Inertial microfluidics direct numerical simulation cell separation CTCs |
| title | Numerical simulation of inertial microfluidics: a review |
| title_full | Numerical simulation of inertial microfluidics: a review |
| title_fullStr | Numerical simulation of inertial microfluidics: a review |
| title_full_unstemmed | Numerical simulation of inertial microfluidics: a review |
| title_short | Numerical simulation of inertial microfluidics: a review |
| title_sort | numerical simulation of inertial microfluidics a review |
| topic | Inertial microfluidics direct numerical simulation cell separation CTCs |
| url | https://www.tandfonline.com/doi/10.1080/19942060.2023.2177350 |
| work_keys_str_mv | AT ruijushi numericalsimulationofinertialmicrofluidicsareview |