Dual blockade of CD47 and CD24 signaling using a novel bispecific antibody fusion protein enhances macrophage immunotherapy

Dual blockade of CD47 and CD24 signaling using a novel bispecific antibody fusion protein enhances macrophage immunotherapy

CD47 and its receptor signal regulatory protein α (SIRPα) act as a dominant antiphagocytic, “don’t eat me” signal. Recent studies reveal CD24 as a novel target for cancer immunotherapy by macrophages in ovarian cancer and breast cancer. However, whether simultaneous blockade of CD47 and CD24 by a bi...

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Bibliographic Details
Main Authors: Yun Yang, He Wu, Yan Yang, Yan Kang, Runjia He, Bei Zhou, Huaizu Guo, Jing Zhang, Jianqin Li, Chunpo Ge, Tianyun Wang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Molecular Therapy: Oncolytics
Subjects:
CD47
CD24
macrophages
bispecific antibody
antitumor immunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000967

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