Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis
The prevalence of being overweight and obese has been expanded dramatically in recent years worldwide. Obesity usually occurs when the energetic introit overtakes energy expenditure from metabolic and physical activity, leading to fat accumulation mainly in the visceral depots. Excessive fat accumul...
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Format: | Article |
Language: | English |
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MDPI AG
2021-06-01
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Series: | Nutrients |
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Online Access: | https://www.mdpi.com/2072-6643/13/6/2101 |
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author | Lucilla Crudele Elena Piccinin Antonio Moschetta |
author_facet | Lucilla Crudele Elena Piccinin Antonio Moschetta |
author_sort | Lucilla Crudele |
collection | DOAJ |
description | The prevalence of being overweight and obese has been expanded dramatically in recent years worldwide. Obesity usually occurs when the energetic introit overtakes energy expenditure from metabolic and physical activity, leading to fat accumulation mainly in the visceral depots. Excessive fat accumulation represents a risk factor for many chronic diseases, including cancer. Adiposity, chronic low-grade inflammation, and hyperinsulinemia are essential factors of obesity that also play a crucial role in tumor onset. In recent years, several strategies have been pointed toward boundary fat accumulation, thus limiting the burden of cancer attributable to obesity. While remodeling fat via adipocytes browning seems a tempting prospect, lifestyle interventions still represent the main pathway to prevent cancer and enhance the efficacy of treatments. Specifically, the Mediterranean Diet stands out as one of the best dietary approaches to curtail visceral adiposity and, therefore, cancer risk. In this Review, the close relationship between obesity and cancer has been investigated, highlighting the biological mechanisms at the basis of this link. Finally, strategies to remodel fat, including browning and lifestyle interventions, have been taken into consideration as a major perspective to limit excess body weight and tumor onset. |
first_indexed | 2024-03-10T10:15:23Z |
format | Article |
id | doaj.art-2e59751963e54cf1976e4cea42979e8e |
institution | Directory Open Access Journal |
issn | 2072-6643 |
language | English |
last_indexed | 2024-03-10T10:15:23Z |
publishDate | 2021-06-01 |
publisher | MDPI AG |
record_format | Article |
series | Nutrients |
spelling | doaj.art-2e59751963e54cf1976e4cea42979e8e2023-11-22T00:51:04ZengMDPI AGNutrients2072-66432021-06-01136210110.3390/nu13062101Visceral Adiposity and Cancer: Role in Pathogenesis and PrognosisLucilla Crudele0Elena Piccinin1Antonio Moschetta2Department of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDepartment of Interdisciplinary Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyThe prevalence of being overweight and obese has been expanded dramatically in recent years worldwide. Obesity usually occurs when the energetic introit overtakes energy expenditure from metabolic and physical activity, leading to fat accumulation mainly in the visceral depots. Excessive fat accumulation represents a risk factor for many chronic diseases, including cancer. Adiposity, chronic low-grade inflammation, and hyperinsulinemia are essential factors of obesity that also play a crucial role in tumor onset. In recent years, several strategies have been pointed toward boundary fat accumulation, thus limiting the burden of cancer attributable to obesity. While remodeling fat via adipocytes browning seems a tempting prospect, lifestyle interventions still represent the main pathway to prevent cancer and enhance the efficacy of treatments. Specifically, the Mediterranean Diet stands out as one of the best dietary approaches to curtail visceral adiposity and, therefore, cancer risk. In this Review, the close relationship between obesity and cancer has been investigated, highlighting the biological mechanisms at the basis of this link. Finally, strategies to remodel fat, including browning and lifestyle interventions, have been taken into consideration as a major perspective to limit excess body weight and tumor onset.https://www.mdpi.com/2072-6643/13/6/2101obesitycancervisceral adiposityMediterranean dietfastinglifestyle interventions |
spellingShingle | Lucilla Crudele Elena Piccinin Antonio Moschetta Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis Nutrients obesity cancer visceral adiposity Mediterranean diet fasting lifestyle interventions |
title | Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis |
title_full | Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis |
title_fullStr | Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis |
title_full_unstemmed | Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis |
title_short | Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis |
title_sort | visceral adiposity and cancer role in pathogenesis and prognosis |
topic | obesity cancer visceral adiposity Mediterranean diet fasting lifestyle interventions |
url | https://www.mdpi.com/2072-6643/13/6/2101 |
work_keys_str_mv | AT lucillacrudele visceraladiposityandcancerroleinpathogenesisandprognosis AT elenapiccinin visceraladiposityandcancerroleinpathogenesisandprognosis AT antoniomoschetta visceraladiposityandcancerroleinpathogenesisandprognosis |