Synthesis, DNA Binding, and Anticancer Properties of Bis-Naphthalimide Derivatives with Lysine-Modified Polyamine Linkers

Synthesis, DNA Binding, and Anticancer Properties of Bis-Naphthalimide Derivatives with Lysine-Modified Polyamine Linkers

A series of bis-naphthalimide derivatives with different diamine linkers were designed and synthesized. All of the synthesized bis-naphthalimide derivatives were characterized by NMR and HRMS spectra. The binding ability between the compounds and CT DNA was evaluated by using UV–Vis titration experi...

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Bibliographic Details
Main Authors: Yu Huang, Chun-Xia Wu, Yu Song, Min Huang, Da-Nian Tian, Xin-Bin Yang, Yan-Ru Fan
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Molecules
Subjects:
bis-naphthalimide derivatives
DNA binding
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/23/2/266

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