4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing
Abstract 4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR admi...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-02-01
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| Series: | Maxillofacial Plastic and Reconstructive Surgery |
| Online Access: | https://doi.org/10.1186/s40902-022-00334-w |
| _version_ | 1818500823127162880 |
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| author | Seong-Gon Kim |
| author_facet | Seong-Gon Kim |
| author_sort | Seong-Gon Kim |
| collection | DOAJ |
| description | Abstract 4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR administration increases VEGF, TGF-β1, and calcification associated proteins. As a consequence, 4HR administration increases angiogenesis and bone formation in wounded area. Strong anti-inflammatory reaction and capillary regeneration in diabetic model demonstrate that 4HR can be applied on many types of surgical wound. |
| first_indexed | 2024-12-10T20:47:59Z |
| format | Article |
| id | doaj.art-2e5d9fc4a92245c2bb0c89d979820496 |
| institution | Directory Open Access Journal |
| issn | 2288-8586 |
| language | English |
| last_indexed | 2024-12-10T20:47:59Z |
| publishDate | 2022-02-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Maxillofacial Plastic and Reconstructive Surgery |
| spelling | doaj.art-2e5d9fc4a92245c2bb0c89d9798204962022-12-22T01:34:10ZengSpringerOpenMaxillofacial Plastic and Reconstructive Surgery2288-85862022-02-0144111010.1186/s40902-022-00334-w4-Hexylresorcinol: pharmacologic chaperone and its application for wound healingSeong-Gon Kim0Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National UniversityAbstract 4-Hexylresorcinol (4HR) is amphiphilic organic chemical and auto-regulator for micro-organism. As 4HR administration induces the stress on the endoplasmic reticulum, 4HR changes protein folding. The application of 4HR inhibits NF-κB signal pathway and TNF-α production. In addition, 4HR administration increases VEGF, TGF-β1, and calcification associated proteins. As a consequence, 4HR administration increases angiogenesis and bone formation in wounded area. Strong anti-inflammatory reaction and capillary regeneration in diabetic model demonstrate that 4HR can be applied on many types of surgical wound.https://doi.org/10.1186/s40902-022-00334-w |
| spellingShingle | Seong-Gon Kim 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing Maxillofacial Plastic and Reconstructive Surgery |
| title | 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing |
| title_full | 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing |
| title_fullStr | 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing |
| title_full_unstemmed | 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing |
| title_short | 4-Hexylresorcinol: pharmacologic chaperone and its application for wound healing |
| title_sort | 4 hexylresorcinol pharmacologic chaperone and its application for wound healing |
| url | https://doi.org/10.1186/s40902-022-00334-w |
| work_keys_str_mv | AT seonggonkim 4hexylresorcinolpharmacologicchaperoneanditsapplicationforwoundhealing |