Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.
The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfa...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-01-01
|
Series: | PLoS ONE |
Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093942&type=printable |
_version_ | 1826586901433286656 |
---|---|
author | Naowarat Tanomsing Mayfong Mayxay Paul N Newton Francois Nosten Christiane Dolecek Tran Tinh Hien Nicholas J White Nicholas P J Day Arjen M Dondorp Mallika Imwong |
author_facet | Naowarat Tanomsing Mayfong Mayxay Paul N Newton Francois Nosten Christiane Dolecek Tran Tinh Hien Nicholas J White Nicholas P J Day Arjen M Dondorp Mallika Imwong |
author_sort | Naowarat Tanomsing |
collection | DOAJ |
description | The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance. |
first_indexed | 2024-12-22T14:08:44Z |
format | Article |
id | doaj.art-2e5dc923cf5442e2ab163e5d4f9e9230 |
institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2025-03-14T16:16:54Z |
publishDate | 2014-01-01 |
publisher | Public Library of Science (PLoS) |
record_format | Article |
series | PLoS ONE |
spelling | doaj.art-2e5dc923cf5442e2ab163e5d4f9e92302025-02-22T05:34:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9394210.1371/journal.pone.0093942Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.Naowarat TanomsingMayfong MayxayPaul N NewtonFrancois NostenChristiane DolecekTran Tinh HienNicholas J WhiteNicholas P J DayArjen M DondorpMallika ImwongThe dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093942&type=printable |
spellingShingle | Naowarat Tanomsing Mayfong Mayxay Paul N Newton Francois Nosten Christiane Dolecek Tran Tinh Hien Nicholas J White Nicholas P J Day Arjen M Dondorp Mallika Imwong Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries. PLoS ONE |
title | Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries. |
title_full | Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries. |
title_fullStr | Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries. |
title_full_unstemmed | Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries. |
title_short | Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries. |
title_sort | genetic variability of plasmodium malariae dihydropteroate synthase dhps in four asian countries |
url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093942&type=printable |
work_keys_str_mv | AT naowarattanomsing geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries AT mayfongmayxay geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries AT paulnnewton geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries AT francoisnosten geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries AT christianedolecek geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries AT trantinhhien geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries AT nicholasjwhite geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries AT nicholaspjday geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries AT arjenmdondorp geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries AT mallikaimwong geneticvariabilityofplasmodiummalariaedihydropteroatesynthasedhpsinfourasiancountries |