Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.

The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfa...

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Main Authors: Naowarat Tanomsing, Mayfong Mayxay, Paul N Newton, Francois Nosten, Christiane Dolecek, Tran Tinh Hien, Nicholas J White, Nicholas P J Day, Arjen M Dondorp, Mallika Imwong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093942&type=printable
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author Naowarat Tanomsing
Mayfong Mayxay
Paul N Newton
Francois Nosten
Christiane Dolecek
Tran Tinh Hien
Nicholas J White
Nicholas P J Day
Arjen M Dondorp
Mallika Imwong
author_facet Naowarat Tanomsing
Mayfong Mayxay
Paul N Newton
Francois Nosten
Christiane Dolecek
Tran Tinh Hien
Nicholas J White
Nicholas P J Day
Arjen M Dondorp
Mallika Imwong
author_sort Naowarat Tanomsing
collection DOAJ
description The dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.
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spelling doaj.art-2e5dc923cf5442e2ab163e5d4f9e92302025-02-22T05:34:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9394210.1371/journal.pone.0093942Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.Naowarat TanomsingMayfong MayxayPaul N NewtonFrancois NostenChristiane DolecekTran Tinh HienNicholas J WhiteNicholas P J DayArjen M DondorpMallika ImwongThe dihydropteroate synthase (dhps) genes of 44 P. malariae strains from four Asian countries were isolated. Only a limited number of polymorphisms were observed. Comparison with homologous mutations in other Plasmodium species showed that these polymorphisms are unlikely to be associated with sulfadoxine resistance.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093942&type=printable
spellingShingle Naowarat Tanomsing
Mayfong Mayxay
Paul N Newton
Francois Nosten
Christiane Dolecek
Tran Tinh Hien
Nicholas J White
Nicholas P J Day
Arjen M Dondorp
Mallika Imwong
Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.
PLoS ONE
title Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.
title_full Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.
title_fullStr Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.
title_full_unstemmed Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.
title_short Genetic variability of Plasmodium malariae dihydropteroate synthase (dhps) in four Asian countries.
title_sort genetic variability of plasmodium malariae dihydropteroate synthase dhps in four asian countries
url https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0093942&type=printable
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