Combination of neutrophil/lymphocyte ratio and albumin/bilirubin grade as a prognostic predictor for hepatocellular carcinoma patients undergoing curative hepatectomy
Abstract Background and aim Prognosis determination is essential for hepatocellular carcinoma (HCC) patient management and treatment planning. The current study aimed to evaluate the prognosis performance of NLR, ALBI, and the combination of NLR-ALBI in determining the overall survival (OS) of HCC p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-05-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-023-02804-5 |
| _version_ | 1797822789636325376 |
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| author | Hao Luo Chongming Huang Meng Meng Ming Zhang Zigang Li Jun Huang |
| author_facet | Hao Luo Chongming Huang Meng Meng Ming Zhang Zigang Li Jun Huang |
| author_sort | Hao Luo |
| collection | DOAJ |
| description | Abstract Background and aim Prognosis determination is essential for hepatocellular carcinoma (HCC) patient management and treatment planning. The current study aimed to evaluate the prognosis performance of NLR, ALBI, and the combination of NLR-ALBI in determining the overall survival (OS) of HCC patients under curative hepatectomy. Methods 144 primary HCC patients with curative hepatectomy were recruited in the retrospective study. The clinicopathologic characteristics and OS were compared between stratified groups. The predictive performance of NLR, ALBI, and the combination of NLR-ALBI was explored by the area under the receiver operating characteristic curve (AUC). Univariate and multivariate analyses were used to determine the risk factors of OS. Results AUC determined NLR cutoff > 2.60 for predicting prognosis. The univariate analysis indicated pathological differentiation, tumor size, AFP, TNM stage, NLR score, and ALBI grade were significant indicators of OS. However, only TMN grade, AFP, NLR score, and NLR-ALBI score were identified as independent predictors of OS in the multivariable analysis. The AUC of NLR, ALBI and the combination of NLR-ALBI was 0.618(95%CI 0.56–0.710), 0.533 (95%CI 0.437–0.629), 0.679 (95%CI 0.592–0.767) respectively. Patients with higher NLR-ALBI scores presented worse outcomes than those with lower NLR-ALBI scores. Conclusion NLR is an independent prognostic factor of HCC and a reliable biomarker in predicting the OS of HCC patients. The combination of NLR-ALBI showed a better prognostic performance than using NLR or ALBI alone, implicating the effectiveness and feasibility of combining multiple risk factors for postoperative prognosis assessment. |
| first_indexed | 2024-03-13T10:14:21Z |
| format | Article |
| id | doaj.art-2e5e8317e85c42a9a715122eb964db0d |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-03-13T10:14:21Z |
| publishDate | 2023-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-2e5e8317e85c42a9a715122eb964db0d2023-05-21T11:17:50ZengBMCBMC Gastroenterology1471-230X2023-05-012311810.1186/s12876-023-02804-5Combination of neutrophil/lymphocyte ratio and albumin/bilirubin grade as a prognostic predictor for hepatocellular carcinoma patients undergoing curative hepatectomyHao Luo0Chongming Huang1Meng Meng2Ming Zhang3Zigang Li4Jun Huang5Department of General Surgery, The First People’s Hospital of YibinDepartment of General Surgery, The First People’s Hospital of YibinDepartment of Gastrointestinal Surgery, Shandong Provincial Third Hospital, Shandong UniversityDepartment of General Surgery, The First People’s Hospital of YibinDepartment of General Surgery, The First People’s Hospital of YibinDepartment of General Surgery, The First People’s Hospital of YibinAbstract Background and aim Prognosis determination is essential for hepatocellular carcinoma (HCC) patient management and treatment planning. The current study aimed to evaluate the prognosis performance of NLR, ALBI, and the combination of NLR-ALBI in determining the overall survival (OS) of HCC patients under curative hepatectomy. Methods 144 primary HCC patients with curative hepatectomy were recruited in the retrospective study. The clinicopathologic characteristics and OS were compared between stratified groups. The predictive performance of NLR, ALBI, and the combination of NLR-ALBI was explored by the area under the receiver operating characteristic curve (AUC). Univariate and multivariate analyses were used to determine the risk factors of OS. Results AUC determined NLR cutoff > 2.60 for predicting prognosis. The univariate analysis indicated pathological differentiation, tumor size, AFP, TNM stage, NLR score, and ALBI grade were significant indicators of OS. However, only TMN grade, AFP, NLR score, and NLR-ALBI score were identified as independent predictors of OS in the multivariable analysis. The AUC of NLR, ALBI and the combination of NLR-ALBI was 0.618(95%CI 0.56–0.710), 0.533 (95%CI 0.437–0.629), 0.679 (95%CI 0.592–0.767) respectively. Patients with higher NLR-ALBI scores presented worse outcomes than those with lower NLR-ALBI scores. Conclusion NLR is an independent prognostic factor of HCC and a reliable biomarker in predicting the OS of HCC patients. The combination of NLR-ALBI showed a better prognostic performance than using NLR or ALBI alone, implicating the effectiveness and feasibility of combining multiple risk factors for postoperative prognosis assessment.https://doi.org/10.1186/s12876-023-02804-5Hepatocellular carcinomaPrognostic factorNeutrophil/lymphocyte ratioAlbumin/Bilirubin gradeOverall survival |
| spellingShingle | Hao Luo Chongming Huang Meng Meng Ming Zhang Zigang Li Jun Huang Combination of neutrophil/lymphocyte ratio and albumin/bilirubin grade as a prognostic predictor for hepatocellular carcinoma patients undergoing curative hepatectomy BMC Gastroenterology Hepatocellular carcinoma Prognostic factor Neutrophil/lymphocyte ratio Albumin/Bilirubin grade Overall survival |
| title | Combination of neutrophil/lymphocyte ratio and albumin/bilirubin grade as a prognostic predictor for hepatocellular carcinoma patients undergoing curative hepatectomy |
| title_full | Combination of neutrophil/lymphocyte ratio and albumin/bilirubin grade as a prognostic predictor for hepatocellular carcinoma patients undergoing curative hepatectomy |
| title_fullStr | Combination of neutrophil/lymphocyte ratio and albumin/bilirubin grade as a prognostic predictor for hepatocellular carcinoma patients undergoing curative hepatectomy |
| title_full_unstemmed | Combination of neutrophil/lymphocyte ratio and albumin/bilirubin grade as a prognostic predictor for hepatocellular carcinoma patients undergoing curative hepatectomy |
| title_short | Combination of neutrophil/lymphocyte ratio and albumin/bilirubin grade as a prognostic predictor for hepatocellular carcinoma patients undergoing curative hepatectomy |
| title_sort | combination of neutrophil lymphocyte ratio and albumin bilirubin grade as a prognostic predictor for hepatocellular carcinoma patients undergoing curative hepatectomy |
| topic | Hepatocellular carcinoma Prognostic factor Neutrophil/lymphocyte ratio Albumin/Bilirubin grade Overall survival |
| url | https://doi.org/10.1186/s12876-023-02804-5 |
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