Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman
Abstract Background Area postrema syndrome (APS) is considered to be one of the most specific clinical presentations of neuromyelitis optica spectrum disorders (NMOSDs). In sub-Saharan Africa, NMOSDs and even more so those revealed by an APS, are rarely reported. However, studies among mixed populat...
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| Format: | Article |
| Language: | English |
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BMC
2019-04-01
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| Series: | BMC Neurology |
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| Online Access: | http://link.springer.com/article/10.1186/s12883-019-1287-5 |
| _version_ | 1828371644442214400 |
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| author | Kossivi Apetse Josué Euberma Diatewa Jean Joel Dongmo Tajeuna Yaovi Mawuéna Dansou Rolph Bakoudissa Kokouvi Panabalo Waklatsi Damelan Kombate Komi Assogba Agnon A. Koffi Balogou |
| author_facet | Kossivi Apetse Josué Euberma Diatewa Jean Joel Dongmo Tajeuna Yaovi Mawuéna Dansou Rolph Bakoudissa Kokouvi Panabalo Waklatsi Damelan Kombate Komi Assogba Agnon A. Koffi Balogou |
| author_sort | Kossivi Apetse |
| collection | DOAJ |
| description | Abstract Background Area postrema syndrome (APS) is considered to be one of the most specific clinical presentations of neuromyelitis optica spectrum disorders (NMOSDs). In sub-Saharan Africa, NMOSDs and even more so those revealed by an APS, are rarely reported. However, studies among mixed populations have shown that NMOSDs disproportionately affect black people with relatively more frequent encephalic involvement. We report a case of APS revealing an NMOSD associated with central nervous system (CNS) tuberculosis in a young Togolese woman residing in Togo (West Africa). Case presentation A 28-year-old Togolese woman was admitted for left hemibody sensory problems with ataxia. These problems were observed while the patient was hospitalized for a few days in the hepato-gastroenterology department for persistent vomiting, abdominal pain and hiccups lasting for about a month. The examination confirmed left hemibody ataxia with nystagmus when looking to the left, pronounced left osteotendinous reflexes, and left hemibody hypoesthesia up to the base of the neck. Encephalic magnetic resonance imaging (MRI) showed a hypersignal lesion in the bulbar more lateralized on the left in the fluid-attenuated inversion recovery sequence, not enhanced after a gadolinium injection. Biological assessment showed the presence of Mycobacterium tuberculosis deoxyribonucleic acid in the cerebrospinal fluid and a sedimentation rate of 120 mm in the 1st hour. The result of the anti-AQP4 antibody test was positive. Two months from the onset of digestive problems with Lhermitte’s sign and hand and foot contracture access without vesico-sphincter problems were established. Cervical medullary MRI showed an additional intramedullary hypersignal lesion in the T2 sequence at the C2 level, not enhanced after a gadolinium injection. A second course of intravenous corticosteroids was administered, and anti-tuberculosis treatment was continued. The outcome was favorable. After 8 months of anti-tuberculosis treatment, the patient started immunosuppressive therapy (azathioprine 50 mg twice daily) to limit the risk of recurrence of NMOSD. Conclusion The recognition of an APS is an additional challenge for the diagnosis of NMOSDs, especially in countries with limited resources. CNS tuberculosis must be tested when faced with an NMOSD because it seems to be a major cause. |
| first_indexed | 2024-04-14T06:52:11Z |
| format | Article |
| id | doaj.art-2e6043db19ff4a8cbb40c2e2c5273141 |
| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-04-14T06:52:11Z |
| publishDate | 2019-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neurology |
| spelling | doaj.art-2e6043db19ff4a8cbb40c2e2c52731412022-12-22T02:06:59ZengBMCBMC Neurology1471-23772019-04-011911410.1186/s12883-019-1287-5Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) womanKossivi Apetse0Josué Euberma Diatewa1Jean Joel Dongmo Tajeuna2Yaovi Mawuéna Dansou3Rolph Bakoudissa4Kokouvi Panabalo Waklatsi5Damelan Kombate6Komi Assogba7Agnon A. Koffi Balogou8Faculte des Sciences de la Sante, Universite de LomeService de Neurologie, CHU CAMPUS de LomeService de Neurologie, CHU CAMPUS de LomeService d’imagerie médicale, CHU Sylvanus OlympioService de Neurologie, CHU CAMPUS de LomeService de Neurologie, CHU CAMPUS de LomeFaculte des Sciences de la Sante, Universite de LomeFaculte des Sciences de la Sante, Universite de LomeFaculte des Sciences de la Sante, Universite de LomeAbstract Background Area postrema syndrome (APS) is considered to be one of the most specific clinical presentations of neuromyelitis optica spectrum disorders (NMOSDs). In sub-Saharan Africa, NMOSDs and even more so those revealed by an APS, are rarely reported. However, studies among mixed populations have shown that NMOSDs disproportionately affect black people with relatively more frequent encephalic involvement. We report a case of APS revealing an NMOSD associated with central nervous system (CNS) tuberculosis in a young Togolese woman residing in Togo (West Africa). Case presentation A 28-year-old Togolese woman was admitted for left hemibody sensory problems with ataxia. These problems were observed while the patient was hospitalized for a few days in the hepato-gastroenterology department for persistent vomiting, abdominal pain and hiccups lasting for about a month. The examination confirmed left hemibody ataxia with nystagmus when looking to the left, pronounced left osteotendinous reflexes, and left hemibody hypoesthesia up to the base of the neck. Encephalic magnetic resonance imaging (MRI) showed a hypersignal lesion in the bulbar more lateralized on the left in the fluid-attenuated inversion recovery sequence, not enhanced after a gadolinium injection. Biological assessment showed the presence of Mycobacterium tuberculosis deoxyribonucleic acid in the cerebrospinal fluid and a sedimentation rate of 120 mm in the 1st hour. The result of the anti-AQP4 antibody test was positive. Two months from the onset of digestive problems with Lhermitte’s sign and hand and foot contracture access without vesico-sphincter problems were established. Cervical medullary MRI showed an additional intramedullary hypersignal lesion in the T2 sequence at the C2 level, not enhanced after a gadolinium injection. A second course of intravenous corticosteroids was administered, and anti-tuberculosis treatment was continued. The outcome was favorable. After 8 months of anti-tuberculosis treatment, the patient started immunosuppressive therapy (azathioprine 50 mg twice daily) to limit the risk of recurrence of NMOSD. Conclusion The recognition of an APS is an additional challenge for the diagnosis of NMOSDs, especially in countries with limited resources. CNS tuberculosis must be tested when faced with an NMOSD because it seems to be a major cause.http://link.springer.com/article/10.1186/s12883-019-1287-5Area postrema syndromeNeuromyelitis optica spectrum disordersTuberculosisTogoAfrica |
| spellingShingle | Kossivi Apetse Josué Euberma Diatewa Jean Joel Dongmo Tajeuna Yaovi Mawuéna Dansou Rolph Bakoudissa Kokouvi Panabalo Waklatsi Damelan Kombate Komi Assogba Agnon A. Koffi Balogou Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman BMC Neurology Area postrema syndrome Neuromyelitis optica spectrum disorders Tuberculosis Togo Africa |
| title | Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman |
| title_full | Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman |
| title_fullStr | Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman |
| title_full_unstemmed | Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman |
| title_short | Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman |
| title_sort | case report an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young togolese black african woman |
| topic | Area postrema syndrome Neuromyelitis optica spectrum disorders Tuberculosis Togo Africa |
| url | http://link.springer.com/article/10.1186/s12883-019-1287-5 |
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