A Straightforward Synthesis of Functionalized <i>cis</i>-Perhydroisoquinolin-1-ones
Base-catalyzed annulation reactions of 5,6-dihydro-2(1<i>H</i>)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied. The process involves two successive Michael additions and stereoselectively provides fun...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-02-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/24/3/557 |