Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy
Khalid Siddiqui,1 Salini Scaria Joy,1 Teena Puthiyaparampil George,1 Muhammad Mujammami,1– 3 Assim A Alfadda1,3,4 1Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2University Diabetes Center, King Saud University Medical City, King S...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-12-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/potential-role-and-excretion-level-of-urinary-transferrin-kim-1-rbp-mc-peer-reviewed-article-DMSO |
| _version_ | 1797935303797768192 |
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| author | Siddiqui K Joy SS George TP Mujammami M Alfadda AA |
| author_facet | Siddiqui K Joy SS George TP Mujammami M Alfadda AA |
| author_sort | Siddiqui K |
| collection | DOAJ |
| description | Khalid Siddiqui,1 Salini Scaria Joy,1 Teena Puthiyaparampil George,1 Muhammad Mujammami,1– 3 Assim A Alfadda1,3,4 1Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia; 3Department of Medicine, College of Medicine, and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia; 4Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Khalid SiddiquiStrategic Center for Diabetes Research, College of Medicine, King Saud University, P.O. Box 245, Riyadh 11411, Kingdom of Saudi ArabiaTel +966 114724179 ext.1340Email ksiddiqui@ksu.edu.saBackground: Analyzing urinary biomarkers may provide better insight into pathophysiological mechanisms of diabetic kidney diseases. The study aimed to analyze the pattern of selected excreted urinary biomarkers and its correlation with albuminuria and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.Methods: A total of 185 patients with type 2 diabetes were categorized according to KDIGO guideline based on albuminuria and eGFR. The urinary markers (transferrin, KIM-1, RBP, MCP-1 and NGAL) were measured by ELISA.Results: The urinary markers were associated with eGFR (total protein/Cr, p=0.001; RBP/Cr, p=0.007; MCP-1/Cr, p=0.023; NGAL/Cr, p=0.011) and albuminuria (total protein/Cr, p< 0.001; transferrin, p< 0.001; RBP/Cr, p< 0.001; MCP-1/Cr, p< 0.001; NGAL/Cr, p=0.002).Conclusion: The urinary marker levels (total protein, RBP, MCP-1, and NGAL) are elevated with severity of kidney damage and expressed more in progressive renal impairment.Keywords: diabetic kidney disease, urinary markers, albuminuria, transferrin, kidney injury molecule-1, retinol-binding protein, monocyte chemoattractant protein-1, neutrophil gelatinase-associated lipocalin |
| first_indexed | 2024-04-10T18:12:20Z |
| format | Article |
| id | doaj.art-2e638a62ea7b45b1a0a6f23bb4bbce56 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:12:20Z |
| publishDate | 2020-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-2e638a62ea7b45b1a0a6f23bb4bbce562023-02-02T10:18:56ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072020-12-01Volume 135103511160823Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic NephropathySiddiqui KJoy SSGeorge TPMujammami MAlfadda AAKhalid Siddiqui,1 Salini Scaria Joy,1 Teena Puthiyaparampil George,1 Muhammad Mujammami,1– 3 Assim A Alfadda1,3,4 1Strategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia; 2University Diabetes Center, King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia; 3Department of Medicine, College of Medicine, and King Saud University Medical City, King Saud University, Riyadh, Saudi Arabia; 4Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi ArabiaCorrespondence: Khalid SiddiquiStrategic Center for Diabetes Research, College of Medicine, King Saud University, P.O. Box 245, Riyadh 11411, Kingdom of Saudi ArabiaTel +966 114724179 ext.1340Email ksiddiqui@ksu.edu.saBackground: Analyzing urinary biomarkers may provide better insight into pathophysiological mechanisms of diabetic kidney diseases. The study aimed to analyze the pattern of selected excreted urinary biomarkers and its correlation with albuminuria and estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes.Methods: A total of 185 patients with type 2 diabetes were categorized according to KDIGO guideline based on albuminuria and eGFR. The urinary markers (transferrin, KIM-1, RBP, MCP-1 and NGAL) were measured by ELISA.Results: The urinary markers were associated with eGFR (total protein/Cr, p=0.001; RBP/Cr, p=0.007; MCP-1/Cr, p=0.023; NGAL/Cr, p=0.011) and albuminuria (total protein/Cr, p< 0.001; transferrin, p< 0.001; RBP/Cr, p< 0.001; MCP-1/Cr, p< 0.001; NGAL/Cr, p=0.002).Conclusion: The urinary marker levels (total protein, RBP, MCP-1, and NGAL) are elevated with severity of kidney damage and expressed more in progressive renal impairment.Keywords: diabetic kidney disease, urinary markers, albuminuria, transferrin, kidney injury molecule-1, retinol-binding protein, monocyte chemoattractant protein-1, neutrophil gelatinase-associated lipocalinhttps://www.dovepress.com/potential-role-and-excretion-level-of-urinary-transferrin-kim-1-rbp-mc-peer-reviewed-article-DMSOdiabetic kidney diseaseurinary markersalbuminuriatransferrinkidney injury molecule-1retinol binding proteinmonocyte chemoattractant protein-1neutrophil gelatinase-associated lipocalin |
| spellingShingle | Siddiqui K Joy SS George TP Mujammami M Alfadda AA Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy Diabetes, Metabolic Syndrome and Obesity diabetic kidney disease urinary markers albuminuria transferrin kidney injury molecule-1 retinol binding protein monocyte chemoattractant protein-1 neutrophil gelatinase-associated lipocalin |
| title | Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy |
| title_full | Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy |
| title_fullStr | Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy |
| title_full_unstemmed | Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy |
| title_short | Potential Role and Excretion Level of Urinary Transferrin, KIM-1, RBP, MCP-1 and NGAL Markers in Diabetic Nephropathy |
| title_sort | potential role and excretion level of urinary transferrin kim 1 rbp mcp 1 and ngal markers in diabetic nephropathy |
| topic | diabetic kidney disease urinary markers albuminuria transferrin kidney injury molecule-1 retinol binding protein monocyte chemoattractant protein-1 neutrophil gelatinase-associated lipocalin |
| url | https://www.dovepress.com/potential-role-and-excretion-level-of-urinary-transferrin-kim-1-rbp-mc-peer-reviewed-article-DMSO |
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