The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility
Aim. We aimed to investigate the demographic and clinical factors associated with TB mortality in patients managed at a tertiary TB referral center. Methods. We conducted a retrospective review of the medical records of 1,933 TB patients seen between January 2017 and December 2020 at the Korle-Bu Te...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | Tuberculosis Research and Treatment |
| Online Access: | http://dx.doi.org/10.1155/2023/6648137 |
| _version_ | 1797371470171602944 |
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| author | Jane S. Afriyie-Mensah Robert Aryee Francisca Zigah Ernest Amaning-Kwarteng Marie Nancy Séraphin |
| author_facet | Jane S. Afriyie-Mensah Robert Aryee Francisca Zigah Ernest Amaning-Kwarteng Marie Nancy Séraphin |
| author_sort | Jane S. Afriyie-Mensah |
| collection | DOAJ |
| description | Aim. We aimed to investigate the demographic and clinical factors associated with TB mortality in patients managed at a tertiary TB referral center. Methods. We conducted a retrospective review of the medical records of 1,933 TB patients seen between January 2017 and December 2020 at the Korle-Bu Teaching Hospital (KBTH) Chest Department in Accra, Ghana. TB mortality was defined as any TB patient who died for any reason during the course of treatment. Multivariable logistic regression was used to estimate adjusted odds ratios with 95% confidence intervals for factors associated with TB mortality. Results. A total of 1,933 patients with TB were registered at the chest clinic over the study period. Males accounted for 1,227 (63.5%), and majority of participants were between 24 and 64 years old. Pulmonary TB (PTB) and extrapulmonary TB (EPTB) cases accounted for 51% and 48.4% of the total TB cases, respectively. A significant proportion (69%) of the patients managed for TB had no bacteriological confirmation of the disease. About 34% of tested TB patients were HIV positive. Mortality among patients was 33.6%. In a multivariable regression model, patients with HIV positive status had over 3-fold increased risk of mortality, compared to those with HIV negative status. TB patients diagnosed empirically had an increased risk of death compared to those with a confirmed diagnosis. Conclusion. The proportion of clinically diagnosed TB was high among the patients seen at the chest clinic. Mortality was high among the patients with HIV/TB coinfection as well as in patients with empirical TB diagnosis. |
| first_indexed | 2024-03-08T18:20:20Z |
| format | Article |
| id | doaj.art-2e64f52a801b4dcdad49801c2dc14ba5 |
| institution | Directory Open Access Journal |
| issn | 2090-1518 |
| language | English |
| last_indexed | 2024-03-08T18:20:20Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Tuberculosis Research and Treatment |
| spelling | doaj.art-2e64f52a801b4dcdad49801c2dc14ba52023-12-31T00:00:04ZengHindawi LimitedTuberculosis Research and Treatment2090-15182023-01-01202310.1155/2023/6648137The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary FacilityJane S. Afriyie-Mensah0Robert Aryee1Francisca Zigah2Ernest Amaning-Kwarteng3Marie Nancy Séraphin4Department of Medicine and TherapeuticsDepartment of PhysiologyKorle-Bu Teaching HospitalDepartment of Medicine and TherapeuticsEmerging Pathogens InstituteAim. We aimed to investigate the demographic and clinical factors associated with TB mortality in patients managed at a tertiary TB referral center. Methods. We conducted a retrospective review of the medical records of 1,933 TB patients seen between January 2017 and December 2020 at the Korle-Bu Teaching Hospital (KBTH) Chest Department in Accra, Ghana. TB mortality was defined as any TB patient who died for any reason during the course of treatment. Multivariable logistic regression was used to estimate adjusted odds ratios with 95% confidence intervals for factors associated with TB mortality. Results. A total of 1,933 patients with TB were registered at the chest clinic over the study period. Males accounted for 1,227 (63.5%), and majority of participants were between 24 and 64 years old. Pulmonary TB (PTB) and extrapulmonary TB (EPTB) cases accounted for 51% and 48.4% of the total TB cases, respectively. A significant proportion (69%) of the patients managed for TB had no bacteriological confirmation of the disease. About 34% of tested TB patients were HIV positive. Mortality among patients was 33.6%. In a multivariable regression model, patients with HIV positive status had over 3-fold increased risk of mortality, compared to those with HIV negative status. TB patients diagnosed empirically had an increased risk of death compared to those with a confirmed diagnosis. Conclusion. The proportion of clinically diagnosed TB was high among the patients seen at the chest clinic. Mortality was high among the patients with HIV/TB coinfection as well as in patients with empirical TB diagnosis.http://dx.doi.org/10.1155/2023/6648137 |
| spellingShingle | Jane S. Afriyie-Mensah Robert Aryee Francisca Zigah Ernest Amaning-Kwarteng Marie Nancy Séraphin The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility Tuberculosis Research and Treatment |
| title | The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility |
| title_full | The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility |
| title_fullStr | The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility |
| title_full_unstemmed | The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility |
| title_short | The Burden of Bacteriologically Negative TB Diagnosis: A Four-Year Review of Tuberculosis Cases at a Tertiary Facility |
| title_sort | burden of bacteriologically negative tb diagnosis a four year review of tuberculosis cases at a tertiary facility |
| url | http://dx.doi.org/10.1155/2023/6648137 |
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