Outpatient therapy with piperacillin/tazobactam using elastomeric pumps in patients with Pseudomonas aeruginosa infection
Abstract The aim of this study was to evaluate the efficacy and safety of outpatient antimicrobial therapy with piperacillin-tazobactam in continuous infusion using elastomeric pumps and to evaluate the economic impact compared with conventional hospital treatment in patients with Pseudomonas aerugi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-88179-7 |
| _version_ | 1818570402887106560 |
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| author | Jose Luis Lamas Ferreiro Judith Álvarez Otero Ana Sanjurjo Rivo Lucía González González Irene Rodríguez Conde María Fernández Soneira Javier Posada García Javier de la Fuente Aguado |
| author_facet | Jose Luis Lamas Ferreiro Judith Álvarez Otero Ana Sanjurjo Rivo Lucía González González Irene Rodríguez Conde María Fernández Soneira Javier Posada García Javier de la Fuente Aguado |
| author_sort | Jose Luis Lamas Ferreiro |
| collection | DOAJ |
| description | Abstract The aim of this study was to evaluate the efficacy and safety of outpatient antimicrobial therapy with piperacillin-tazobactam in continuous infusion using elastomeric pumps and to evaluate the economic impact compared with conventional hospital treatment in patients with Pseudomonas aeruginosa (PA) infections. This is an observational study. Patients with PA infection treated with continuous piperacillin-tazobactam infusion using elastomeric pumps in our hospital between January 2015 and December 2017 were included. Primary outcomes were mortality during antibiotic treatment and mortality at 30 days. Secondary outcomes were reinfection or relapse at 30 days and clinical cure rate. The cost of each episode was compared with theoretical cost of the same treatment using conventional hospitalization. 35 patients were included. One patient (2.9%) died during the treatment. Overall 30-day mortality was 5.7%. No death was related to infection by PA. One patient (2.9%) had a reinfection at 30 days. Cure was achieved in 93% of patients at the end of treatment. There were no severe complications related to elastomeric pumps. Treatment cost with outpatient antimicrobial therapy was 67% lower than theoretical cost with conventional hospital treatment. Oupatient antimicrobial therapy with piperacillin-tazobactam in continuous infusion using elastomeric pumps in patients with PA infections is safe and effective with lower costs. |
| first_indexed | 2024-12-14T13:40:48Z |
| format | Article |
| id | doaj.art-2e67001240094fa9a004bb7c9c0b0b1a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-14T13:40:48Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2e67001240094fa9a004bb7c9c0b0b1a2022-12-21T22:59:27ZengNature PortfolioScientific Reports2045-23222021-04-011111410.1038/s41598-021-88179-7Outpatient therapy with piperacillin/tazobactam using elastomeric pumps in patients with Pseudomonas aeruginosa infectionJose Luis Lamas Ferreiro0Judith Álvarez Otero1Ana Sanjurjo Rivo2Lucía González González3Irene Rodríguez Conde4María Fernández Soneira5Javier Posada García6Javier de la Fuente Aguado7Internal Medicine (Infectious Diseases Unit), Ribera Povisa HospitalInternal Medicine (Infectious Diseases Unit), Ribera Povisa HospitalInternal Medicine (Infectious Diseases Unit), Ribera Povisa HospitalInternal Medicine, Ribera Povisa HospitalMicrobiology, Ribera Povisa HospitalMicrobiology, Ribera Povisa HospitalHospital at Home, Ribera Povisa HospitalInternal Medicine, Ribera Povisa HospitalAbstract The aim of this study was to evaluate the efficacy and safety of outpatient antimicrobial therapy with piperacillin-tazobactam in continuous infusion using elastomeric pumps and to evaluate the economic impact compared with conventional hospital treatment in patients with Pseudomonas aeruginosa (PA) infections. This is an observational study. Patients with PA infection treated with continuous piperacillin-tazobactam infusion using elastomeric pumps in our hospital between January 2015 and December 2017 were included. Primary outcomes were mortality during antibiotic treatment and mortality at 30 days. Secondary outcomes were reinfection or relapse at 30 days and clinical cure rate. The cost of each episode was compared with theoretical cost of the same treatment using conventional hospitalization. 35 patients were included. One patient (2.9%) died during the treatment. Overall 30-day mortality was 5.7%. No death was related to infection by PA. One patient (2.9%) had a reinfection at 30 days. Cure was achieved in 93% of patients at the end of treatment. There were no severe complications related to elastomeric pumps. Treatment cost with outpatient antimicrobial therapy was 67% lower than theoretical cost with conventional hospital treatment. Oupatient antimicrobial therapy with piperacillin-tazobactam in continuous infusion using elastomeric pumps in patients with PA infections is safe and effective with lower costs.https://doi.org/10.1038/s41598-021-88179-7 |
| spellingShingle | Jose Luis Lamas Ferreiro Judith Álvarez Otero Ana Sanjurjo Rivo Lucía González González Irene Rodríguez Conde María Fernández Soneira Javier Posada García Javier de la Fuente Aguado Outpatient therapy with piperacillin/tazobactam using elastomeric pumps in patients with Pseudomonas aeruginosa infection Scientific Reports |
| title | Outpatient therapy with piperacillin/tazobactam using elastomeric pumps in patients with Pseudomonas aeruginosa infection |
| title_full | Outpatient therapy with piperacillin/tazobactam using elastomeric pumps in patients with Pseudomonas aeruginosa infection |
| title_fullStr | Outpatient therapy with piperacillin/tazobactam using elastomeric pumps in patients with Pseudomonas aeruginosa infection |
| title_full_unstemmed | Outpatient therapy with piperacillin/tazobactam using elastomeric pumps in patients with Pseudomonas aeruginosa infection |
| title_short | Outpatient therapy with piperacillin/tazobactam using elastomeric pumps in patients with Pseudomonas aeruginosa infection |
| title_sort | outpatient therapy with piperacillin tazobactam using elastomeric pumps in patients with pseudomonas aeruginosa infection |
| url | https://doi.org/10.1038/s41598-021-88179-7 |
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