Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community‐Based Study
Background Diabetic kidney disease (DKD) is a common diabetic complication and increases the complexity of diabetes management. No prospective study has focused on the association between DKD and Life's Essential 8 (LE8). Our study aims to examine the association between LE8 and DKD risk. Metho...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-09-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.123.029399 |
| _version_ | 1797689823004196864 |
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| author | Jingli Gao Yang Liu Ning Ning Jing Wang Xiaolan Li Aitian Wang Shuohua Chen Liang Guo Zhaogui Wu Xueying Qin Yanan Ma Shouling Wu |
| author_facet | Jingli Gao Yang Liu Ning Ning Jing Wang Xiaolan Li Aitian Wang Shuohua Chen Liang Guo Zhaogui Wu Xueying Qin Yanan Ma Shouling Wu |
| author_sort | Jingli Gao |
| collection | DOAJ |
| description | Background Diabetic kidney disease (DKD) is a common diabetic complication and increases the complexity of diabetes management. No prospective study has focused on the association between DKD and Life's Essential 8 (LE8). Our study aims to examine the association between LE8 and DKD risk. Methods and Results A total of 7605 participants, aged 54.32±9.77 years, and 4688 participants, aged 56.11±10.38 years, were included in the longitudinal and trajectory analyses, respectively, from 2006 to 2020. The DKD was confirmed using data collected during each follow‐up. LE8 was based on 4 health behaviors and 4 health factors. The range of each metric was 0 to 100, and the overall LE8 score was calculated as the unweighted average of all 8 component metric scores. The trajectories of LE8 during 2006 to 2010 were classified using latent mixture models. Cox models and restricted cubic splines were applied. After a median follow‐up of 12.41 and 6.71 years in longitudinal and trajectory analyses, respectively, the DKD incidence decreased, with the LE8 level increasing (P‐trend<0.05), and the linearity assumption for this relationship (P‐nonlinear=0.685) had been satisfied. Adjusted hazard ratios (HRs) for the highest tertile were 0.77 (95% CI, 0.69–0.87) and 0.70 (95% CI, 0.62–0.78) in baseline and time‐updated LE8 scores, respectively, compared with the lowest tertile. Adjusted HR was 0.53 (95% CI, 0.41–0.69) for the stable‐high pattern compared with the stable‐low pattern. Conclusions Although LE8 is an indicator of cardiovascular health, the beneficial impact of a high LE8 score is also evident in the protection of renal health among patients with diabetes. |
| first_indexed | 2024-03-12T01:51:03Z |
| format | Article |
| id | doaj.art-2e670bbc07db4c30acf7cd723f175bad |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-12T01:51:03Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-2e670bbc07db4c30acf7cd723f175bad2023-09-08T12:39:35ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-09-01121710.1161/JAHA.123.029399Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community‐Based StudyJingli Gao0Yang Liu1Ning Ning2Jing Wang3Xiaolan Li4Aitian Wang5Shuohua Chen6Liang Guo7Zhaogui Wu8Xueying Qin9Yanan Ma10Shouling Wu11Department of Intensive Care Unit Kailuan General Hospital Tangshan Hebei ChinaDepartment of Epidemiology and Biostatistics, School of Public Health China Medical University Shenyang Liaoning ChinaDepartment of Epidemiology and Biostatistics, School of Public Health China Medical University Shenyang Liaoning ChinaPeking University Medical Informatics Center, Peking University Beijing ChinaDepartment of Intensive Care Unit Kailuan General Hospital Tangshan Hebei ChinaDepartment of Intensive Care Unit Kailuan General Hospital Tangshan Hebei ChinaDepartment of Cardiology Kailuan General Hospital Tangshan Hebei ChinaDepartment of Cardiology Renmin Hospital of Wuhan University Wuhan Hubei ChinaDepartment of Cardiology Tianjin Medical University, General Hospital Tianjin ChinaDepartment of Epidemiology and Biostatistics, School of Public Health Peking University Beijing ChinaDepartment of Epidemiology and Biostatistics, School of Public Health China Medical University Shenyang Liaoning ChinaDepartment of Cardiology Kailuan General Hospital Tangshan Hebei ChinaBackground Diabetic kidney disease (DKD) is a common diabetic complication and increases the complexity of diabetes management. No prospective study has focused on the association between DKD and Life's Essential 8 (LE8). Our study aims to examine the association between LE8 and DKD risk. Methods and Results A total of 7605 participants, aged 54.32±9.77 years, and 4688 participants, aged 56.11±10.38 years, were included in the longitudinal and trajectory analyses, respectively, from 2006 to 2020. The DKD was confirmed using data collected during each follow‐up. LE8 was based on 4 health behaviors and 4 health factors. The range of each metric was 0 to 100, and the overall LE8 score was calculated as the unweighted average of all 8 component metric scores. The trajectories of LE8 during 2006 to 2010 were classified using latent mixture models. Cox models and restricted cubic splines were applied. After a median follow‐up of 12.41 and 6.71 years in longitudinal and trajectory analyses, respectively, the DKD incidence decreased, with the LE8 level increasing (P‐trend<0.05), and the linearity assumption for this relationship (P‐nonlinear=0.685) had been satisfied. Adjusted hazard ratios (HRs) for the highest tertile were 0.77 (95% CI, 0.69–0.87) and 0.70 (95% CI, 0.62–0.78) in baseline and time‐updated LE8 scores, respectively, compared with the lowest tertile. Adjusted HR was 0.53 (95% CI, 0.41–0.69) for the stable‐high pattern compared with the stable‐low pattern. Conclusions Although LE8 is an indicator of cardiovascular health, the beneficial impact of a high LE8 score is also evident in the protection of renal health among patients with diabetes.https://www.ahajournals.org/doi/10.1161/JAHA.123.029399cardiovascular healthdiabetic kidney diseaseLife's Essential 8longitudinalpatients with diabetestrajectory |
| spellingShingle | Jingli Gao Yang Liu Ning Ning Jing Wang Xiaolan Li Aitian Wang Shuohua Chen Liang Guo Zhaogui Wu Xueying Qin Yanan Ma Shouling Wu Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community‐Based Study Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease cardiovascular health diabetic kidney disease Life's Essential 8 longitudinal patients with diabetes trajectory |
| title | Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community‐Based Study |
| title_full | Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community‐Based Study |
| title_fullStr | Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community‐Based Study |
| title_full_unstemmed | Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community‐Based Study |
| title_short | Better Life's Essential 8 Is Associated With Lower Risk of Diabetic Kidney Disease: A Community‐Based Study |
| title_sort | better life s essential 8 is associated with lower risk of diabetic kidney disease a community based study |
| topic | cardiovascular health diabetic kidney disease Life's Essential 8 longitudinal patients with diabetes trajectory |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.123.029399 |
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