Functional diversity of excitatory commissural interneurons in adult zebrafish
Flexibility in the bilateral coordination of muscle contraction underpins variable locomotor movements or gaits. While the locomotor rhythm is generated by ipsilateral excitatory interneurons, less is known about the commissural excitatory interneurons. Here we examined how the activity of the V0v i...
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Format: | Article |
Language: | English |
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eLife Sciences Publications Ltd
2016-08-01
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Series: | eLife |
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Online Access: | https://elifesciences.org/articles/18579 |
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author | E Rebecka Björnfors Abdeljabbar El Manira |
author_facet | E Rebecka Björnfors Abdeljabbar El Manira |
author_sort | E Rebecka Björnfors |
collection | DOAJ |
description | Flexibility in the bilateral coordination of muscle contraction underpins variable locomotor movements or gaits. While the locomotor rhythm is generated by ipsilateral excitatory interneurons, less is known about the commissural excitatory interneurons. Here we examined how the activity of the V0v interneurons – an important commissural neuronal class – varies with the locomotor speed in adult zebrafish. Although V0v interneurons are molecularly homogenous, their activity pattern during locomotion is not uniform. They consist of two distinct types dependent on whether they display rhythmicity or not during locomotion. The rhythmic V0v interneurons were further subdivided into three sub-classes engaged sequentially, first at slow then intermediate and finally fast locomotor speeds. Their order of recruitment is defined by scaling their synaptic current with their input resistance. Thus we uncover, in an adult vertebrate, a novel organizational principle for a key class of commissural interneurons and their recruitment pattern as a function of locomotor speed. |
first_indexed | 2024-04-14T07:48:40Z |
format | Article |
id | doaj.art-2e67182eb1884859958f3ec7b4304ff4 |
institution | Directory Open Access Journal |
issn | 2050-084X |
language | English |
last_indexed | 2024-04-14T07:48:40Z |
publishDate | 2016-08-01 |
publisher | eLife Sciences Publications Ltd |
record_format | Article |
series | eLife |
spelling | doaj.art-2e67182eb1884859958f3ec7b4304ff42022-12-22T02:05:15ZengeLife Sciences Publications LtdeLife2050-084X2016-08-01510.7554/eLife.18579Functional diversity of excitatory commissural interneurons in adult zebrafishE Rebecka Björnfors0Abdeljabbar El Manira1https://orcid.org/0000-0001-5920-9384Department of Neuroscience, Karolinska Institute, Stockholm, SwedenDepartment of Neuroscience, Karolinska Institute, Stockholm, SwedenFlexibility in the bilateral coordination of muscle contraction underpins variable locomotor movements or gaits. While the locomotor rhythm is generated by ipsilateral excitatory interneurons, less is known about the commissural excitatory interneurons. Here we examined how the activity of the V0v interneurons – an important commissural neuronal class – varies with the locomotor speed in adult zebrafish. Although V0v interneurons are molecularly homogenous, their activity pattern during locomotion is not uniform. They consist of two distinct types dependent on whether they display rhythmicity or not during locomotion. The rhythmic V0v interneurons were further subdivided into three sub-classes engaged sequentially, first at slow then intermediate and finally fast locomotor speeds. Their order of recruitment is defined by scaling their synaptic current with their input resistance. Thus we uncover, in an adult vertebrate, a novel organizational principle for a key class of commissural interneurons and their recruitment pattern as a function of locomotor speed.https://elifesciences.org/articles/18579spinal cordlocomotioninterneuronszebrafish |
spellingShingle | E Rebecka Björnfors Abdeljabbar El Manira Functional diversity of excitatory commissural interneurons in adult zebrafish eLife spinal cord locomotion interneurons zebrafish |
title | Functional diversity of excitatory commissural interneurons in adult zebrafish |
title_full | Functional diversity of excitatory commissural interneurons in adult zebrafish |
title_fullStr | Functional diversity of excitatory commissural interneurons in adult zebrafish |
title_full_unstemmed | Functional diversity of excitatory commissural interneurons in adult zebrafish |
title_short | Functional diversity of excitatory commissural interneurons in adult zebrafish |
title_sort | functional diversity of excitatory commissural interneurons in adult zebrafish |
topic | spinal cord locomotion interneurons zebrafish |
url | https://elifesciences.org/articles/18579 |
work_keys_str_mv | AT erebeckabjornfors functionaldiversityofexcitatorycommissuralinterneuronsinadultzebrafish AT abdeljabbarelmanira functionaldiversityofexcitatorycommissuralinterneuronsinadultzebrafish |