Functional diversity of excitatory commissural interneurons in adult zebrafish

Flexibility in the bilateral coordination of muscle contraction underpins variable locomotor movements or gaits. While the locomotor rhythm is generated by ipsilateral excitatory interneurons, less is known about the commissural excitatory interneurons. Here we examined how the activity of the V0v i...

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Main Authors: E Rebecka Björnfors, Abdeljabbar El Manira
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/18579
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author E Rebecka Björnfors
Abdeljabbar El Manira
author_facet E Rebecka Björnfors
Abdeljabbar El Manira
author_sort E Rebecka Björnfors
collection DOAJ
description Flexibility in the bilateral coordination of muscle contraction underpins variable locomotor movements or gaits. While the locomotor rhythm is generated by ipsilateral excitatory interneurons, less is known about the commissural excitatory interneurons. Here we examined how the activity of the V0v interneurons – an important commissural neuronal class – varies with the locomotor speed in adult zebrafish. Although V0v interneurons are molecularly homogenous, their activity pattern during locomotion is not uniform. They consist of two distinct types dependent on whether they display rhythmicity or not during locomotion. The rhythmic V0v interneurons were further subdivided into three sub-classes engaged sequentially, first at slow then intermediate and finally fast locomotor speeds. Their order of recruitment is defined by scaling their synaptic current with their input resistance. Thus we uncover, in an adult vertebrate, a novel organizational principle for a key class of commissural interneurons and their recruitment pattern as a function of locomotor speed.
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spelling doaj.art-2e67182eb1884859958f3ec7b4304ff42022-12-22T02:05:15ZengeLife Sciences Publications LtdeLife2050-084X2016-08-01510.7554/eLife.18579Functional diversity of excitatory commissural interneurons in adult zebrafishE Rebecka Björnfors0Abdeljabbar El Manira1https://orcid.org/0000-0001-5920-9384Department of Neuroscience, Karolinska Institute, Stockholm, SwedenDepartment of Neuroscience, Karolinska Institute, Stockholm, SwedenFlexibility in the bilateral coordination of muscle contraction underpins variable locomotor movements or gaits. While the locomotor rhythm is generated by ipsilateral excitatory interneurons, less is known about the commissural excitatory interneurons. Here we examined how the activity of the V0v interneurons – an important commissural neuronal class – varies with the locomotor speed in adult zebrafish. Although V0v interneurons are molecularly homogenous, their activity pattern during locomotion is not uniform. They consist of two distinct types dependent on whether they display rhythmicity or not during locomotion. The rhythmic V0v interneurons were further subdivided into three sub-classes engaged sequentially, first at slow then intermediate and finally fast locomotor speeds. Their order of recruitment is defined by scaling their synaptic current with their input resistance. Thus we uncover, in an adult vertebrate, a novel organizational principle for a key class of commissural interneurons and their recruitment pattern as a function of locomotor speed.https://elifesciences.org/articles/18579spinal cordlocomotioninterneuronszebrafish
spellingShingle E Rebecka Björnfors
Abdeljabbar El Manira
Functional diversity of excitatory commissural interneurons in adult zebrafish
eLife
spinal cord
locomotion
interneurons
zebrafish
title Functional diversity of excitatory commissural interneurons in adult zebrafish
title_full Functional diversity of excitatory commissural interneurons in adult zebrafish
title_fullStr Functional diversity of excitatory commissural interneurons in adult zebrafish
title_full_unstemmed Functional diversity of excitatory commissural interneurons in adult zebrafish
title_short Functional diversity of excitatory commissural interneurons in adult zebrafish
title_sort functional diversity of excitatory commissural interneurons in adult zebrafish
topic spinal cord
locomotion
interneurons
zebrafish
url https://elifesciences.org/articles/18579
work_keys_str_mv AT erebeckabjornfors functionaldiversityofexcitatorycommissuralinterneuronsinadultzebrafish
AT abdeljabbarelmanira functionaldiversityofexcitatorycommissuralinterneuronsinadultzebrafish