<it>HLA-Cw*04 </it>allele associated with nevirapine-induced rash in HIV-infected Thai patients
<p>Abstract</p> <p>Background</p> <p>A high incidence of rash has been reported in HIV-1 patients who received the anti-retroviral drug nevirapine. In addition, several studies have suggested that polymorphisms of human leukocyte antigen (<it>HLA</it>) genes...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-10-01
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| Series: | AIDS Research and Therapy |
| Online Access: | http://www.aidsrestherapy.com/content/6/1/22 |
| _version_ | 1819122906262667264 |
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| author | Tunthanathip Preecha Prasithsirikul Wisit Uttayamakul Sumonmal Feangvad Siriluk Rattanatham Tippawan Likanonsakul Sirirat Nakayama Emi E Shioda Tatsuo |
| author_facet | Tunthanathip Preecha Prasithsirikul Wisit Uttayamakul Sumonmal Feangvad Siriluk Rattanatham Tippawan Likanonsakul Sirirat Nakayama Emi E Shioda Tatsuo |
| author_sort | Tunthanathip Preecha |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>A high incidence of rash has been reported in HIV-1 patients who received the anti-retroviral drug nevirapine. In addition, several studies have suggested that polymorphisms of human leukocyte antigen (<it>HLA</it>) genes may play important roles in nevirapine-induced rash. The aim of the present study was to evaluate the effects of different <it>HLA-C </it>alleles on rash associated with nevirapine in patients who started highly active anti-retroviral therapy (HAART) containing nevirapine in Thailand.</p> <p>Results</p> <p>A case-control study was carried out involving HIV-1 patients under treatment at Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand between March 2007 and March 2008. The study included all HIV/AIDS patients being treated with nevirapine-containing regimens. The study population comprised 287 HIV/AIDS patients of whom 248 were nevirapine-tolerant and 39 developed rash after nevirapine treatment. From the nevirapine-tolerant patients, 60 were selected as the control group on the basis of age, sex, and therapy history matched for nevirapine-induced rash cases. We observed significantly more <it>HLA-Cw*04 </it>alleles in nevirapine-induced rash cases than in nevirapine-tolerant group, with frequencies of 20.51% and 7.50%, respectively (P = 0.009). There were no significant differences between the rash and tolerant groups for other <it>HLA-C </it>alleles except for <it>HLA-Cw*03 </it>(P = 0.015).</p> <p>Conclusion</p> <p>This study suggests that <it>HLA-Cw*04 </it>is associated with rash in nevirapine treated Thais. Future screening of patients' <it>HLA </it>may reduce the number of nevirapine-induced rash cases, and patients with alleles associated with nevirapine-induced rash should be started on anti-retroviral therapy without nevirapine.</p> |
| first_indexed | 2024-12-22T06:59:54Z |
| format | Article |
| id | doaj.art-2e6894df86be4be79623b5d5c64003ca |
| institution | Directory Open Access Journal |
| issn | 1742-6405 |
| language | English |
| last_indexed | 2024-12-22T06:59:54Z |
| publishDate | 2009-10-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj.art-2e6894df86be4be79623b5d5c64003ca2022-12-21T18:34:50ZengBMCAIDS Research and Therapy1742-64052009-10-01612210.1186/1742-6405-6-22<it>HLA-Cw*04 </it>allele associated with nevirapine-induced rash in HIV-infected Thai patientsTunthanathip PreechaPrasithsirikul WisitUttayamakul SumonmalFeangvad SirilukRattanatham TippawanLikanonsakul SiriratNakayama Emi EShioda Tatsuo<p>Abstract</p> <p>Background</p> <p>A high incidence of rash has been reported in HIV-1 patients who received the anti-retroviral drug nevirapine. In addition, several studies have suggested that polymorphisms of human leukocyte antigen (<it>HLA</it>) genes may play important roles in nevirapine-induced rash. The aim of the present study was to evaluate the effects of different <it>HLA-C </it>alleles on rash associated with nevirapine in patients who started highly active anti-retroviral therapy (HAART) containing nevirapine in Thailand.</p> <p>Results</p> <p>A case-control study was carried out involving HIV-1 patients under treatment at Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand between March 2007 and March 2008. The study included all HIV/AIDS patients being treated with nevirapine-containing regimens. The study population comprised 287 HIV/AIDS patients of whom 248 were nevirapine-tolerant and 39 developed rash after nevirapine treatment. From the nevirapine-tolerant patients, 60 were selected as the control group on the basis of age, sex, and therapy history matched for nevirapine-induced rash cases. We observed significantly more <it>HLA-Cw*04 </it>alleles in nevirapine-induced rash cases than in nevirapine-tolerant group, with frequencies of 20.51% and 7.50%, respectively (P = 0.009). There were no significant differences between the rash and tolerant groups for other <it>HLA-C </it>alleles except for <it>HLA-Cw*03 </it>(P = 0.015).</p> <p>Conclusion</p> <p>This study suggests that <it>HLA-Cw*04 </it>is associated with rash in nevirapine treated Thais. Future screening of patients' <it>HLA </it>may reduce the number of nevirapine-induced rash cases, and patients with alleles associated with nevirapine-induced rash should be started on anti-retroviral therapy without nevirapine.</p>http://www.aidsrestherapy.com/content/6/1/22 |
| spellingShingle | Tunthanathip Preecha Prasithsirikul Wisit Uttayamakul Sumonmal Feangvad Siriluk Rattanatham Tippawan Likanonsakul Sirirat Nakayama Emi E Shioda Tatsuo <it>HLA-Cw*04 </it>allele associated with nevirapine-induced rash in HIV-infected Thai patients AIDS Research and Therapy |
| title | <it>HLA-Cw*04 </it>allele associated with nevirapine-induced rash in HIV-infected Thai patients |
| title_full | <it>HLA-Cw*04 </it>allele associated with nevirapine-induced rash in HIV-infected Thai patients |
| title_fullStr | <it>HLA-Cw*04 </it>allele associated with nevirapine-induced rash in HIV-infected Thai patients |
| title_full_unstemmed | <it>HLA-Cw*04 </it>allele associated with nevirapine-induced rash in HIV-infected Thai patients |
| title_short | <it>HLA-Cw*04 </it>allele associated with nevirapine-induced rash in HIV-infected Thai patients |
| title_sort | it hla cw 04 it allele associated with nevirapine induced rash in hiv infected thai patients |
| url | http://www.aidsrestherapy.com/content/6/1/22 |
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