The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomy
Abstract Background Growing evidence indicates that the systemic inflammatory response plays an important role in cancer development and progression. Several inflammatory markers have been reported to be associated with clinical outcomes in patients with various types of cancer. This study was desig...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-020-07482-0 |
| _version_ | 1828476602345848832 |
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| author | Shuxin Sun Chaobin He Jun Wang Xin Huang Jiali Wu Shengping Li |
| author_facet | Shuxin Sun Chaobin He Jun Wang Xin Huang Jiali Wu Shengping Li |
| author_sort | Shuxin Sun |
| collection | DOAJ |
| description | Abstract Background Growing evidence indicates that the systemic inflammatory response plays an important role in cancer development and progression. Several inflammatory markers have been reported to be associated with clinical outcomes in patients with various types of cancer. This study was designed to evaluate the prognostic value of inflammatory indexes in patients with ampullary cancer (AC) who underwent pancreaticoduodenectomy (PD). Methods We retrospectively reviewed the data of 358 patients with AC who underwent PD between 2009 and 2018. R software was used to compare the area under the time-dependent receiver operating characteristic (ROC) curves (AUROCs) of the inflammation-based indexes, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), modified Glasgow Prognostic Score (mGPS), prognostic nutritional index (PNI) and prognostic index (PI), in terms of their predictive value for survival. The survival differences of these indexes were compared by the Kaplan-Meier method and univariate and multivariate analyses were performed to determine the prognostic factors of disease-free survival (DFS) and overall survival (OS). Results The estimated 1-, 2-, and 3-year OS and DFS rates were 83.9, 65.8, and 55.2% and 58.0, 42.8, and 37.8%, respectively, for the entire cohort. The survival differences were significant in terms of OS and DFS when patients were stratified by these inflammation-based indexes. The comparisons of the AUROCs of these inflammation-based indexes illustrated that NLR and PI displayed the highest prognostic value, compared to the other indexes. When NLR and PI were combined, NLR-PI showed even higher AUROC values and was identified as a significant prognostic factor for OS and DFS. Conclusion Specific inflammatory indexes, such as NLR, PLR and dNLR, were found to be able to predict the OS or DFS of patients. As a novel inflammatory index, the level of NLR-PI, which can be regarded as a more useful prognostic index, exhibited strong predictive power for predicting the prognosis of patients with AC after the PD procedure. |
| first_indexed | 2024-12-11T06:31:09Z |
| format | Article |
| id | doaj.art-2e69070f2ed14964bfe64b26680a9126 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-11T06:31:09Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-2e69070f2ed14964bfe64b26680a91262022-12-22T01:17:30ZengBMCBMC Cancer1471-24072020-10-0120111310.1186/s12885-020-07482-0The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomyShuxin Sun0Chaobin He1Jun Wang2Xin Huang3Jiali Wu4Shengping Li5Department of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterDepartment of Pancreatobiliary Surgery, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer CenterAbstract Background Growing evidence indicates that the systemic inflammatory response plays an important role in cancer development and progression. Several inflammatory markers have been reported to be associated with clinical outcomes in patients with various types of cancer. This study was designed to evaluate the prognostic value of inflammatory indexes in patients with ampullary cancer (AC) who underwent pancreaticoduodenectomy (PD). Methods We retrospectively reviewed the data of 358 patients with AC who underwent PD between 2009 and 2018. R software was used to compare the area under the time-dependent receiver operating characteristic (ROC) curves (AUROCs) of the inflammation-based indexes, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), modified Glasgow Prognostic Score (mGPS), prognostic nutritional index (PNI) and prognostic index (PI), in terms of their predictive value for survival. The survival differences of these indexes were compared by the Kaplan-Meier method and univariate and multivariate analyses were performed to determine the prognostic factors of disease-free survival (DFS) and overall survival (OS). Results The estimated 1-, 2-, and 3-year OS and DFS rates were 83.9, 65.8, and 55.2% and 58.0, 42.8, and 37.8%, respectively, for the entire cohort. The survival differences were significant in terms of OS and DFS when patients were stratified by these inflammation-based indexes. The comparisons of the AUROCs of these inflammation-based indexes illustrated that NLR and PI displayed the highest prognostic value, compared to the other indexes. When NLR and PI were combined, NLR-PI showed even higher AUROC values and was identified as a significant prognostic factor for OS and DFS. Conclusion Specific inflammatory indexes, such as NLR, PLR and dNLR, were found to be able to predict the OS or DFS of patients. As a novel inflammatory index, the level of NLR-PI, which can be regarded as a more useful prognostic index, exhibited strong predictive power for predicting the prognosis of patients with AC after the PD procedure.http://link.springer.com/article/10.1186/s12885-020-07482-0Neutrophil-to-lymphocyte ratioPrognostic indexDisease-free survivalOverall survivalAmpullary cancerPancreaticoduodenectomy |
| spellingShingle | Shuxin Sun Chaobin He Jun Wang Xin Huang Jiali Wu Shengping Li The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomy BMC Cancer Neutrophil-to-lymphocyte ratio Prognostic index Disease-free survival Overall survival Ampullary cancer Pancreaticoduodenectomy |
| title | The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomy |
| title_full | The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomy |
| title_fullStr | The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomy |
| title_full_unstemmed | The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomy |
| title_short | The prognostic significance of inflammation-based scores in patients with ampullary carcinoma after pancreaticoduodenectomy |
| title_sort | prognostic significance of inflammation based scores in patients with ampullary carcinoma after pancreaticoduodenectomy |
| topic | Neutrophil-to-lymphocyte ratio Prognostic index Disease-free survival Overall survival Ampullary cancer Pancreaticoduodenectomy |
| url | http://link.springer.com/article/10.1186/s12885-020-07482-0 |
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