Prehypertension and Chronic Kidney Disease in Chinese Population: Four-Year Follow-Up Study.

Hypertension is a well established cause of chronic kidney disease (CKD). However, the effect of prehypertension on risk of CKD is controversial. The aim of this study is to determine whether prehypertension increases the risk of CKD events in the Chinese population. We enrolled 20,034 with prehyper...

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Main Authors: Hao Xue, Jianli Wang, Jinhong Hou, Junjuan Li, Jingsheng Gao, Shuohua Chen, Hang Zhu, Shouling Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4682865?pdf=render
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author Hao Xue
Jianli Wang
Jinhong Hou
Junjuan Li
Jingsheng Gao
Shuohua Chen
Hang Zhu
Shouling Wu
author_facet Hao Xue
Jianli Wang
Jinhong Hou
Junjuan Li
Jingsheng Gao
Shuohua Chen
Hang Zhu
Shouling Wu
author_sort Hao Xue
collection DOAJ
description Hypertension is a well established cause of chronic kidney disease (CKD). However, the effect of prehypertension on risk of CKD is controversial. The aim of this study is to determine whether prehypertension increases the risk of CKD events in the Chinese population. We enrolled 20,034 with prehypertension and 12,351 with ideal blood pressure in this prospective study. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 ml/min 1.73 m2. The new occurrences of CKD events were collected during follow-up. Cumulative survival and freedom for the occurrence of new CKD events was analyzed using the Kaplan-Meier approach. Multivariate Cox Regression was used to analyze the effect of prehypertension on CKD. The median follow-up time was 47 (interquartile range 44-51) months. 601 new onset CKD events occurred during the follow-up period. The cumulative incidence of new CKD events was higher in the prehypertensive population than that in the ideal blood pressure population (2.10% vs 1.46%, P = 0.0001). Multivariate Cox Regression showed that relative risks (RRs) for the new onset CKD events in the prehypertensive population were 1.69 (95% confidence intervals (CI): 1.41~2.04, P = 0.001) higher than those in the ideal blood pressure population. Similarly, the risks were 1.68 (95% CI: 1.33~2.13 P = 0.001) times higher in females and 2.14 (95% CI: 1.58~2.91 P = 0.001) times higher in males by adjustment for traditional CV risk factors. Our findings demonstrated prehypertension is an independent risk factor for the occurrence of new CKD events in the Chinese population.
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spelling doaj.art-2e6a9785a1f64a96b56875c3190688952022-12-21T22:46:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014443810.1371/journal.pone.0144438Prehypertension and Chronic Kidney Disease in Chinese Population: Four-Year Follow-Up Study.Hao XueJianli WangJinhong HouJunjuan LiJingsheng GaoShuohua ChenHang ZhuShouling WuHypertension is a well established cause of chronic kidney disease (CKD). However, the effect of prehypertension on risk of CKD is controversial. The aim of this study is to determine whether prehypertension increases the risk of CKD events in the Chinese population. We enrolled 20,034 with prehypertension and 12,351 with ideal blood pressure in this prospective study. CKD was defined as an estimated glomerular filtration rate (eGFR) <60 ml/min 1.73 m2. The new occurrences of CKD events were collected during follow-up. Cumulative survival and freedom for the occurrence of new CKD events was analyzed using the Kaplan-Meier approach. Multivariate Cox Regression was used to analyze the effect of prehypertension on CKD. The median follow-up time was 47 (interquartile range 44-51) months. 601 new onset CKD events occurred during the follow-up period. The cumulative incidence of new CKD events was higher in the prehypertensive population than that in the ideal blood pressure population (2.10% vs 1.46%, P = 0.0001). Multivariate Cox Regression showed that relative risks (RRs) for the new onset CKD events in the prehypertensive population were 1.69 (95% confidence intervals (CI): 1.41~2.04, P = 0.001) higher than those in the ideal blood pressure population. Similarly, the risks were 1.68 (95% CI: 1.33~2.13 P = 0.001) times higher in females and 2.14 (95% CI: 1.58~2.91 P = 0.001) times higher in males by adjustment for traditional CV risk factors. Our findings demonstrated prehypertension is an independent risk factor for the occurrence of new CKD events in the Chinese population.http://europepmc.org/articles/PMC4682865?pdf=render
spellingShingle Hao Xue
Jianli Wang
Jinhong Hou
Junjuan Li
Jingsheng Gao
Shuohua Chen
Hang Zhu
Shouling Wu
Prehypertension and Chronic Kidney Disease in Chinese Population: Four-Year Follow-Up Study.
PLoS ONE
title Prehypertension and Chronic Kidney Disease in Chinese Population: Four-Year Follow-Up Study.
title_full Prehypertension and Chronic Kidney Disease in Chinese Population: Four-Year Follow-Up Study.
title_fullStr Prehypertension and Chronic Kidney Disease in Chinese Population: Four-Year Follow-Up Study.
title_full_unstemmed Prehypertension and Chronic Kidney Disease in Chinese Population: Four-Year Follow-Up Study.
title_short Prehypertension and Chronic Kidney Disease in Chinese Population: Four-Year Follow-Up Study.
title_sort prehypertension and chronic kidney disease in chinese population four year follow up study
url http://europepmc.org/articles/PMC4682865?pdf=render
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