Halogenation generates effective modulators of amyloid-Beta aggregation and neurotoxicity.

Halogenation generates effective modulators of amyloid-Beta aggregation and neurotoxicity.

Halogenation of organic compounds plays diverse roles in biochemistry, including selective chemical modification of proteins and improved oral absorption/blood-brain barrier permeability of drug candidates. Moreover, halogenation of aromatic molecules greatly affects aromatic interaction-mediated se...

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Bibliographic Details
Main Authors: H Edward Wong, Jacob A Irwin, Inchan Kwon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3585355?pdf=render

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