The application of serum N-MID in auxiliary diagnosis and therapeutic effect monitoring of bone metastasis in patients with primary lung cancer
Background and purpose: There is a lack of serum markers for the diagnosis of bone metastasis in patients with primary lung cancer currently. This study aimed to explore the expression level of serum N-terminal mid-fragment (N-MID) of osteocalcin (OC) and its functions in the diagnosis and therapy m...
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| Format: | Article |
| Language: | English |
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Editorial Office of China Oncology
2021-09-01
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| Series: | Zhongguo aizheng zazhi |
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| Online Access: | http://www.china-oncology.com/fileup/1007-3639/PDF/20210910.pdf |
| _version_ | 1797989815802658816 |
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| author | LU Li, LU Renquan, SUN Jiajun, LU Ning, GUO Lin |
| author_facet | LU Li, LU Renquan, SUN Jiajun, LU Ning, GUO Lin |
| author_sort | LU Li, LU Renquan, SUN Jiajun, LU Ning, GUO Lin |
| collection | DOAJ |
| description | Background and purpose: There is a lack of serum markers for the diagnosis of bone metastasis in patients with primary lung cancer currently. This study aimed to explore the expression level of serum N-terminal mid-fragment (N-MID) of osteocalcin (OC) and its functions in the diagnosis and therapy monitoring of bone metastasis in patients with lung cancer. Methods: A total of 231 patients with clinically classified primary lung cancer in Fudan University Shanghai Cancer Centre from March 2017 to February 2018 were enrolled as the experimental group, including 97 patients with bone metastasis and 134 without bone metastasis. Sixty-nine healthy adults without cancer were included in the same period as the healthy control group. Serum levels of N-MID, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 fragment (CYFRA21-1) and alkaline phosphatase (ALP) were measured. The correlation with clinical characteristics of bone metastasis in lung cancer was analyzed by using multivariate logistic regression analysis. Results: Expression levels of N-MID before treatment were significantly higher in the bone metastasis group than in the group without bone metastasis (P ＜ 0.001) and healthy control group (P ＜ 0.001). According to the results of multivariate logistic regression analysis, the serum levels of N-MID (OR=9.265) and NSE (OR=2.688) were risk factors of bone metastasis in lung cancer patients. The cut-off level of serum N-MID was determined as 14.96ng/mL by the receiver operating characteristic (ROC) curve, and the experimental group was divided into two subgroups. The progression-free survival (PFS) of lung cancer patients whose serum N-MID levels were higher than 14.96ng/mL before treatment was significantly lower than that of patients with N-MID level lower than 14.96ng/mL (HR=2.040). In lung cancer patients with bone metastasis, the decrease of serum N-MID level after treatment indicated remission (P ＜ 0.001). Conclusion: The serum level of N-MID is closely correlated to the bone metastasis in lung cancer. The detection of serum N-MID before and after treatment can be applied in both auxiliary diagnosis and monitoring therapeutic effect in lung cancer patients with bone metastasis. |
| first_indexed | 2024-04-11T08:26:31Z |
| format | Article |
| id | doaj.art-2e6e33eb0e694a9388de28e738e118f2 |
| institution | Directory Open Access Journal |
| issn | 1007-3639 |
| language | English |
| last_indexed | 2024-04-11T08:26:31Z |
| publishDate | 2021-09-01 |
| publisher | Editorial Office of China Oncology |
| record_format | Article |
| series | Zhongguo aizheng zazhi |
| spelling | doaj.art-2e6e33eb0e694a9388de28e738e118f22022-12-22T04:34:44ZengEditorial Office of China OncologyZhongguo aizheng zazhi1007-36392021-09-0131983884410.19401/j.cnki.1007-3639.2021.09.010The application of serum N-MID in auxiliary diagnosis and therapeutic effect monitoring of bone metastasis in patients with primary lung cancerLU Li, LU Renquan, SUN Jiajun, LU Ning, GUO Lin0Department of Clinical Laboratory, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, ChinaBackground and purpose: There is a lack of serum markers for the diagnosis of bone metastasis in patients with primary lung cancer currently. This study aimed to explore the expression level of serum N-terminal mid-fragment (N-MID) of osteocalcin (OC) and its functions in the diagnosis and therapy monitoring of bone metastasis in patients with lung cancer. Methods: A total of 231 patients with clinically classified primary lung cancer in Fudan University Shanghai Cancer Centre from March 2017 to February 2018 were enrolled as the experimental group, including 97 patients with bone metastasis and 134 without bone metastasis. Sixty-nine healthy adults without cancer were included in the same period as the healthy control group. Serum levels of N-MID, carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin 19 fragment (CYFRA21-1) and alkaline phosphatase (ALP) were measured. The correlation with clinical characteristics of bone metastasis in lung cancer was analyzed by using multivariate logistic regression analysis. Results: Expression levels of N-MID before treatment were significantly higher in the bone metastasis group than in the group without bone metastasis (P ＜ 0.001) and healthy control group (P ＜ 0.001). According to the results of multivariate logistic regression analysis, the serum levels of N-MID (OR=9.265) and NSE (OR=2.688) were risk factors of bone metastasis in lung cancer patients. The cut-off level of serum N-MID was determined as 14.96ng/mL by the receiver operating characteristic (ROC) curve, and the experimental group was divided into two subgroups. The progression-free survival (PFS) of lung cancer patients whose serum N-MID levels were higher than 14.96ng/mL before treatment was significantly lower than that of patients with N-MID level lower than 14.96ng/mL (HR=2.040). In lung cancer patients with bone metastasis, the decrease of serum N-MID level after treatment indicated remission (P ＜ 0.001). Conclusion: The serum level of N-MID is closely correlated to the bone metastasis in lung cancer. The detection of serum N-MID before and after treatment can be applied in both auxiliary diagnosis and monitoring therapeutic effect in lung cancer patients with bone metastasis.http://www.china-oncology.com/fileup/1007-3639/PDF/20210910.pdfprimary lung cancer|bone metastasis|n-terminal mid-fragment|auxiliary diagnosis|therapeutic effect monitoring |
| spellingShingle | LU Li, LU Renquan, SUN Jiajun, LU Ning, GUO Lin The application of serum N-MID in auxiliary diagnosis and therapeutic effect monitoring of bone metastasis in patients with primary lung cancer Zhongguo aizheng zazhi primary lung cancer|bone metastasis|n-terminal mid-fragment|auxiliary diagnosis|therapeutic effect monitoring |
| title | The application of serum N-MID in auxiliary diagnosis and therapeutic effect monitoring of bone metastasis in patients with primary lung cancer |
| title_full | The application of serum N-MID in auxiliary diagnosis and therapeutic effect monitoring of bone metastasis in patients with primary lung cancer |
| title_fullStr | The application of serum N-MID in auxiliary diagnosis and therapeutic effect monitoring of bone metastasis in patients with primary lung cancer |
| title_full_unstemmed | The application of serum N-MID in auxiliary diagnosis and therapeutic effect monitoring of bone metastasis in patients with primary lung cancer |
| title_short | The application of serum N-MID in auxiliary diagnosis and therapeutic effect monitoring of bone metastasis in patients with primary lung cancer |
| title_sort | application of serum n mid in auxiliary diagnosis and therapeutic effect monitoring of bone metastasis in patients with primary lung cancer |
| topic | primary lung cancer|bone metastasis|n-terminal mid-fragment|auxiliary diagnosis|therapeutic effect monitoring |
| url | http://www.china-oncology.com/fileup/1007-3639/PDF/20210910.pdf |
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