Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants
The development of premature coronary artery disease (PCAD) is dependent on both genetic predisposition and traditional risk factors. Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies. Genome-wide association studies (GWASs) have identified a con...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-03-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304220301343 |
| _version_ | 1827267912068497408 |
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| author | Haiming Wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin Wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang |
| author_facet | Haiming Wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin Wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang |
| author_sort | Haiming Wang |
| collection | DOAJ |
| description | The development of premature coronary artery disease (PCAD) is dependent on both genetic predisposition and traditional risk factors. Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies. Genome-wide association studies (GWASs) have identified a considerable number of common genetic variants that are associated with PCAD. Most of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms (SNPs). The genetic variants that predispose individuals to developing PCAD may depend on race and ethnicity. Some characteristic genetic variants have been identified in Chinese populations. Although translating this genetic knowledge into clinical applications is still challenging, these genetic variants can be used for CAD phenotype identification, genetic prediction and therapy. In this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of PCAD. We will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD. |
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| format | Article |
| id | doaj.art-2e6ebab9f6c74b79ae4b78f3bc1f1eea |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2025-03-22T04:41:16Z |
| publishDate | 2022-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-2e6ebab9f6c74b79ae4b78f3bc1f1eea2024-04-27T22:29:03ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422022-03-0192370380Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variantsHaiming Wang0Zifan Liu1Junjie Shao2Min Jiang3Xuechun Lu4Lejian Lin5Lin Wang6Qiang Xu7Haomin Zhang8Xin Li9Jingjing Zhou10Yundai Chen11Ran Zhang12Department of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaDepartment of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaThe First Clinical Medical College of Inner Mongolia Medical University, Hohhot 010059, PR ChinaDepartment of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaDepartment of Hematology, The Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaDepartment of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaDepartment of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaDepartment of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaDepartment of Hematology, The Second Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaDepartment of Health Services, The First Medical Center of Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaDepartment of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR ChinaDepartment of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR China; Corresponding author. Department of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, 28 Fuxing Road, Beijing 100853, PR China.Department of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, Beijing 100853, PR China; Corresponding author. Department of Cardiovascular Medicine, Chinese PLA General Hospital & Chinese PLA Medical School, 28 Fuxing Road, Beijing 100853, PR China.The development of premature coronary artery disease (PCAD) is dependent on both genetic predisposition and traditional risk factors. Strategies for unraveling the genetic basis of PCAD have evolved with the advent of modern technologies. Genome-wide association studies (GWASs) have identified a considerable number of common genetic variants that are associated with PCAD. Most of these genetic variants are attributable to lipid and blood pressure-related single-nucleotide polymorphisms (SNPs). The genetic variants that predispose individuals to developing PCAD may depend on race and ethnicity. Some characteristic genetic variants have been identified in Chinese populations. Although translating this genetic knowledge into clinical applications is still challenging, these genetic variants can be used for CAD phenotype identification, genetic prediction and therapy. In this article we will provide a comprehensive review of genetic variants detected by GWASs that are predicted to contribute to the development of PCAD. We will highlight recent findings regarding CAD-related genetic variants in Chinese populations and discuss the potential clinical utility of genetic variants for preventing and managing PCAD.http://www.sciencedirect.com/science/article/pii/S2352304220301343Genetic clinical applicationsGenetic variantsGenome-wide association studiesPremature coronary artery diseaseSingle-nucleotide polymorphisms |
| spellingShingle | Haiming Wang Zifan Liu Junjie Shao Min Jiang Xuechun Lu Lejian Lin Lin Wang Qiang Xu Haomin Zhang Xin Li Jingjing Zhou Yundai Chen Ran Zhang Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants Genes and Diseases Genetic clinical applications Genetic variants Genome-wide association studies Premature coronary artery disease Single-nucleotide polymorphisms |
| title | Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants |
| title_full | Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants |
| title_fullStr | Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants |
| title_full_unstemmed | Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants |
| title_short | Pathogenesis of premature coronary artery disease: Focus on risk factors and genetic variants |
| title_sort | pathogenesis of premature coronary artery disease focus on risk factors and genetic variants |
| topic | Genetic clinical applications Genetic variants Genome-wide association studies Premature coronary artery disease Single-nucleotide polymorphisms |
| url | http://www.sciencedirect.com/science/article/pii/S2352304220301343 |
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