Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds
<p>Abstract</p> <p>Hematological parameters and the state of liver cells of rats were examined in vivo after the animals received aflatoxin B<sub>1</sub> (AfB<sub>1</sub>) alone and together with modified nanodiamonds (MND) synthesized by detonation. The rat...
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Format: | Article |
Language: | English |
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SpringerOpen
2010-01-01
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Series: | Nanoscale Research Letters |
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Online Access: | http://dx.doi.org/10.1007/s11671-010-9571-8 |
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author | Baron AV Mogilnaya OA Puzyr AP Bondar VS |
author_facet | Baron AV Mogilnaya OA Puzyr AP Bondar VS |
author_sort | Baron AV |
collection | DOAJ |
description | <p>Abstract</p> <p>Hematological parameters and the state of liver cells of rats were examined in vivo after the animals received aflatoxin B<sub>1</sub> (AfB<sub>1</sub>) alone and together with modified nanodiamonds (MND) synthesized by detonation. The rats that had received the MND hydrosol had elevated leukocyte levels, mainly due to higher granulocyte counts and somewhat increased monocyte counts compared to control rats. Hematological parameters of the rats that had received AfB<sub>1</sub> alone differed from those of the control rats in another way: total white blood cell counts were significantly lower due to the decreased lymphocyte counts. In rats that had consumed AfB<sub>1</sub> with the MND hydrosol, changes in hematological parameters were less pronounced than in rats that had consumed either AfB<sub>1</sub> or MND. Electron microscopy showed that hepatocytes of the rats that had received the MND hydrosol or AfB<sub>1</sub> with the MND hydrosol contained elevated levels of lipid inclusions and lysosomes. Hyperplasia of the smooth endoplasmic reticulum (EPR) was revealed in liver specimens of the rats that had received AfB<sub>1</sub>. Results of the study suggest the conclusion about mutual mitigation of the effects of nanoparticles and the mycotoxin on rats blood and liver cells after AfB<sub>1</sub> has adsorbed on MND.</p> |
first_indexed | 2024-03-12T07:10:57Z |
format | Article |
id | doaj.art-2e6f168a264a4f46bef7d6b2fc738d44 |
institution | Directory Open Access Journal |
issn | 1931-7573 1556-276X |
language | English |
last_indexed | 2024-03-12T07:10:57Z |
publishDate | 2010-01-01 |
publisher | SpringerOpen |
record_format | Article |
series | Nanoscale Research Letters |
spelling | doaj.art-2e6f168a264a4f46bef7d6b2fc738d442023-09-02T23:06:23ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2010-01-0155908912Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with NanodiamondsBaron AVMogilnaya OAPuzyr APBondar VS<p>Abstract</p> <p>Hematological parameters and the state of liver cells of rats were examined in vivo after the animals received aflatoxin B<sub>1</sub> (AfB<sub>1</sub>) alone and together with modified nanodiamonds (MND) synthesized by detonation. The rats that had received the MND hydrosol had elevated leukocyte levels, mainly due to higher granulocyte counts and somewhat increased monocyte counts compared to control rats. Hematological parameters of the rats that had received AfB<sub>1</sub> alone differed from those of the control rats in another way: total white blood cell counts were significantly lower due to the decreased lymphocyte counts. In rats that had consumed AfB<sub>1</sub> with the MND hydrosol, changes in hematological parameters were less pronounced than in rats that had consumed either AfB<sub>1</sub> or MND. Electron microscopy showed that hepatocytes of the rats that had received the MND hydrosol or AfB<sub>1</sub> with the MND hydrosol contained elevated levels of lipid inclusions and lysosomes. Hyperplasia of the smooth endoplasmic reticulum (EPR) was revealed in liver specimens of the rats that had received AfB<sub>1</sub>. Results of the study suggest the conclusion about mutual mitigation of the effects of nanoparticles and the mycotoxin on rats blood and liver cells after AfB<sub>1</sub> has adsorbed on MND.</p>http://dx.doi.org/10.1007/s11671-010-9571-8NanodiamondsAflatoxin B<sub>1</sub>DetoxificationAdsorbent |
spellingShingle | Baron AV Mogilnaya OA Puzyr AP Bondar VS Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds Nanoscale Research Letters Nanodiamonds Aflatoxin B<sub>1</sub> Detoxification Adsorbent |
title | Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds |
title_full | Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds |
title_fullStr | Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds |
title_full_unstemmed | Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds |
title_short | Hematological Parameters and the State of Liver Cells of Rats After Oral Administration of Aflatoxin B1 Alone and Together with Nanodiamonds |
title_sort | hematological parameters and the state of liver cells of rats after oral administration of aflatoxin b1 alone and together with nanodiamonds |
topic | Nanodiamonds Aflatoxin B<sub>1</sub> Detoxification Adsorbent |
url | http://dx.doi.org/10.1007/s11671-010-9571-8 |
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