THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASE
The objective of research was to study the state of prooxidant and antioxidant systems in the tissues of the lungs, kidneys, pancreas and salivary glands at burn disease. The intensity of the free radical processes was evaluated on the basis of the content of malondialdehyde (MDA) and antioxidant sy...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2014-06-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/53 |
| _version_ | 1797872954195836928 |
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| author | L. G. Netyukhailo T. A. Sukhomlin Ya. A. Basarab V. V. Bondarenko S. V. Kharchenko |
| author_facet | L. G. Netyukhailo T. A. Sukhomlin Ya. A. Basarab V. V. Bondarenko S. V. Kharchenko |
| author_sort | L. G. Netyukhailo |
| collection | DOAJ |
| description | The objective of research was to study the state of prooxidant and antioxidant systems in the tissues of the lungs, kidneys, pancreas and salivary glands at burn disease. The intensity of the free radical processes was evaluated on the basis of the content of malondialdehyde (MDA) and antioxidant system – based on the indexes of its enzymatic chain: superoxide dismutase and catalase in homogenates of the studied organs. It has been found that changes in experimental burn disease depend on the studied organs and the stage of burn disease. The activation of free radical processes observed in all investigated organs (lungs, kidneys, pancreas and salivary glands). Reactive oxygen species induce lipid peroxidation, which is a universal marker of tissue damage. MDA appears in the body during degradation of polyunsaturated fatty acids and it’s a marker of lipid peroxidation and oxidative stress. It was found the increasing of MDA in all organs, especially in the lungs and kidneys at stage of burn shock. Under these conditions it was observed the decrease of superoxide dismutase and catalase in all investigated organs. At burn disease there is development of disbalance between the action of prooxidant and antioxidant systems due to the activation of free radical processes. |
| first_indexed | 2024-04-10T01:07:14Z |
| format | Article |
| id | doaj.art-2e72429196a9436e88ec73a3cb9d820d |
| institution | Directory Open Access Journal |
| issn | 1682-0363 1819-3684 |
| language | English |
| last_indexed | 2024-04-10T01:07:14Z |
| publishDate | 2014-06-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj.art-2e72429196a9436e88ec73a3cb9d820d2023-03-13T09:58:20ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842014-06-01133515510.20538/1682-0363-2014-3-51-5551THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASEL. G. Netyukhailo0T. A. Sukhomlin1Ya. A. Basarab2V. V. Bondarenko3S. V. Kharchenko4Украинская медицинская стоматологическая академия, ПолтаваУкраинская медицинская стоматологическая академия, ПолтаваУкраинская медицинская стоматологическая академия, ПолтаваУкраинская медицинская стоматологическая академия, ПолтаваУкраинская медицинская стоматологическая академия, ПолтаваThe objective of research was to study the state of prooxidant and antioxidant systems in the tissues of the lungs, kidneys, pancreas and salivary glands at burn disease. The intensity of the free radical processes was evaluated on the basis of the content of malondialdehyde (MDA) and antioxidant system – based on the indexes of its enzymatic chain: superoxide dismutase and catalase in homogenates of the studied organs. It has been found that changes in experimental burn disease depend on the studied organs and the stage of burn disease. The activation of free radical processes observed in all investigated organs (lungs, kidneys, pancreas and salivary glands). Reactive oxygen species induce lipid peroxidation, which is a universal marker of tissue damage. MDA appears in the body during degradation of polyunsaturated fatty acids and it’s a marker of lipid peroxidation and oxidative stress. It was found the increasing of MDA in all organs, especially in the lungs and kidneys at stage of burn shock. Under these conditions it was observed the decrease of superoxide dismutase and catalase in all investigated organs. At burn disease there is development of disbalance between the action of prooxidant and antioxidant systems due to the activation of free radical processes.https://bulletin.ssmu.ru/jour/article/view/53ожоговая болезньоксидативный стрессантиоксидантная системалегкиепочкиподжелудочная железаслюнные железы |
| spellingShingle | L. G. Netyukhailo T. A. Sukhomlin Ya. A. Basarab V. V. Bondarenko S. V. Kharchenko THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASE Бюллетень сибирской медицины ожоговая болезнь оксидативный стресс антиоксидантная система легкие почки поджелудочная железа слюнные железы |
| title | THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASE |
| title_full | THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASE |
| title_fullStr | THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASE |
| title_full_unstemmed | THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASE |
| title_short | THE STATE OF THE ANTIOXIDANT SYSTEM OF THE INTERNAL ORGANS IN RATS DURING BURN DISEASE |
| title_sort | state of the antioxidant system of the internal organs in rats during burn disease |
| topic | ожоговая болезнь оксидативный стресс антиоксидантная система легкие почки поджелудочная железа слюнные железы |
| url | https://bulletin.ssmu.ru/jour/article/view/53 |
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