Mutation of FMDV Lpro H138 residue drives viral attenuation in cell culture and in vivo in swine

Mutation of FMDV Lpro H138 residue drives viral attenuation in cell culture and in vivo in swine

The foot-and-mouth disease virus (FMDV) leader proteinase (Lpro) is a papain like protease that cleaves the viral polyprotein and several host factors affecting host cell translation and induction of innate immunity. Introduction of Lpro mutations ablating catalytic activity is not tolerated by the...

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Bibliographic Details
Main Authors:	Paul A. Azzinaro, Gisselle N. Medina, Devendra Rai, Elizabeth Ramirez-Medina, Edward Spinard, Monica Rodriguez-Calzada, James Zhu, Elizabeth Rieder, Teresa de los Santos, Fayna Díaz-San Segundo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Veterinary Science
Subjects:	FMDV foot-and-mouth disease virus leader proteinase Lpro attenuated virus
Online Access:	https://www.frontiersin.org/articles/10.3389/fvets.2022.1028077/full

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