Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?
Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RR...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/13/10/306 |
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| author | Stephanie Kourakis Cara A. Timpani Judy B. de Haan Nuri Gueven Dirk Fischer Emma Rybalka |
| author_facet | Stephanie Kourakis Cara A. Timpani Judy B. de Haan Nuri Gueven Dirk Fischer Emma Rybalka |
| author_sort | Stephanie Kourakis |
| collection | DOAJ |
| description | Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RRMS share an immune-mediated aetiology, driven by severe inflammation and oxidative stress. DMF, as well as monomethyl fumarate and diroximel fumarate, are commonly prescribed first-line agents with favourable safety and efficacy profiles. The potential benefits of FAEs against other diseases that appear pathogenically different but share the pathologies of oxidative stress and inflammation are currently investigated. |
| first_indexed | 2024-03-10T15:39:16Z |
| format | Article |
| id | doaj.art-2e7350fa9ec64be49028730d3806aac5 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T15:39:16Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-2e7350fa9ec64be49028730d3806aac52023-11-20T16:55:31ZengMDPI AGPharmaceuticals1424-82472020-10-01131030610.3390/ph13100306Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?Stephanie Kourakis0Cara A. Timpani1Judy B. de Haan2Nuri Gueven3Dirk Fischer4Emma Rybalka5College of Health and Biomedicine, Victoria University, Melbourne, VIC 8001, AustraliaInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, AustraliaOxidative Stress Laboratory, Baker Heart and Diabetes Institute, Basic Science Domain, Melbourne, VIC 3004, AustraliaSchool of Pharmacy and Pharmacology, University of Tasmania, Hobart, TAS 7005, AustraliaDivision of Developmental- and Neuropediatrics, University Children’s Hospital Basel, University of Basel, 4056 Basel, SwitzerlandInstitute for Health and Sport, Victoria University, Melbourne, VIC 8001, AustraliaFumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RRMS share an immune-mediated aetiology, driven by severe inflammation and oxidative stress. DMF, as well as monomethyl fumarate and diroximel fumarate, are commonly prescribed first-line agents with favourable safety and efficacy profiles. The potential benefits of FAEs against other diseases that appear pathogenically different but share the pathologies of oxidative stress and inflammation are currently investigated.https://www.mdpi.com/1424-8247/13/10/306clinical applicationdimethyl fumaratediseasefumaric acid estersoxidative stressinflammation |
| spellingShingle | Stephanie Kourakis Cara A. Timpani Judy B. de Haan Nuri Gueven Dirk Fischer Emma Rybalka Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? Pharmaceuticals clinical application dimethyl fumarate disease fumaric acid esters oxidative stress inflammation |
| title | Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? |
| title_full | Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? |
| title_fullStr | Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? |
| title_full_unstemmed | Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? |
| title_short | Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility? |
| title_sort | dimethyl fumarate and its esters a drug with broad clinical utility |
| topic | clinical application dimethyl fumarate disease fumaric acid esters oxidative stress inflammation |
| url | https://www.mdpi.com/1424-8247/13/10/306 |
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