Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members.

Changes in dynamics upon oligomerization regulate substrate binding and allostery in amino acid kinase family members.

Oligomerization is a functional requirement for many proteins. The interfacial interactions and the overall packing geometry of the individual monomers are viewed as important determinants of the thermodynamic stability and allosteric regulation of oligomers. The present study focuses on the role of...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Enrique Marcos, Ramon Crehuet, Ivet Bahar
Fformat:	Erthygl
Iaith:	English
Cyhoeddwyd:	Public Library of Science (PLoS) 2011-09-01
Cyfres:	PLoS Computational Biology
Mynediad Ar-lein:	http://europepmc.org/articles/PMC3182869?pdf=render

Eitemau Tebyg

On the conservation of the slow conformational dynamics within the amino acid kinase family: NAGK the paradigm.
gan: Enrique Marcos, et al.
Cyhoeddwyd: (2010-04-01)

Dynamic allostery in substrate binding by human thymidylate synthase
gan: Jeffrey P Bonin, et al.
Cyhoeddwyd: (2022-10-01)

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases.
gan: Nikita Chopra, et al.
Cyhoeddwyd: (2016-03-01)

ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.
gan: Ignacio J General, et al.
Cyhoeddwyd: (2014-05-01)

Computational modeling of cAMP-dependent protein kinase allostery
gan: Andrei Izvolski, et al.
Cyhoeddwyd: (2023-11-01)

Genetic Mutations in the S-loop of Human Glutathione Synthetase: Links Between Substrate Binding, Active Site Structure and Allostery
gan: Brandall L. Ingle, et al.
Cyhoeddwyd: (2019-01-01)

Editorial: Understanding Protein Dynamics, Binding and Allostery for Drug Design
gan: Guang Hu, et al.
Cyhoeddwyd: (2021-04-01)

Kinase Domain Is a Dynamic Hub for Driving LRRK2 Allostery
gan: Susan S. Taylor, et al.
Cyhoeddwyd: (2020-10-01)

Modeling Spatial Correlation of DNA Deformation: DNA Allostery in Protein Binding
gan: Xu, Xinliang, et al.
Cyhoeddwyd: (2014)

Wandering about allostery
gan: Maurizio Brunori
Cyhoeddwyd: (2024-08-01)

Decoding the mechanisms of allostery
gan: Saif Khan, et al.
Cyhoeddwyd: (2023-06-01)

Allostery can convert binding free energies into concerted domain motions in enzymes
gan: Nicole Stéphanie Galenkamp, et al.
Cyhoeddwyd: (2024-11-01)

Ligand structure controlled allostery in cAMP-dependent protein kinase catalytic subunit
gan: Kuznetsov Aleksei, et al.
Cyhoeddwyd: (2009-06-01)

Is allostery a fuzzy concept?
gan: Veronica Morea, et al.
Cyhoeddwyd: (2024-07-01)

The role of the N domain in substrate binding, oligomerization, and allosteric regulation of the AAA+ Lon protease
gan: Wohlever, Matthew L
Cyhoeddwyd: (2013)

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain
gan: Aprile, F, et al.
Cyhoeddwyd: (2013)

Hsp70 oligomerization is mediated by an interaction between the interdomain linker and the substrate-binding domain.
gan: Francesco A Aprile, et al.
Cyhoeddwyd: (2013-01-01)

Deconstructing allostery by computational assessment of the binding determinants of allosteric PTP1B modulators
gan: Adele Hardie, et al.
Cyhoeddwyd: (2023-06-01)

Structures of S. aureus thymidylate kinase reveal an atypical active site configuration and an intermediate conformational state upon substrate binding.
gan: Kotaka, M, et al.
Cyhoeddwyd: (2006)

Structure based biophysical characterization of the PROPPIN Atg18 shows Atg18 oligomerization upon membrane binding
gan: Scacioc, A, et al.
Cyhoeddwyd: (2018)

GMP Synthetase: Allostery, Structure, and Function
gan: Lionel Ballut, et al.
Cyhoeddwyd: (2023-09-01)

Dynamic allostery in thrombin—a review
gan: Elizabeth A. Komives
Cyhoeddwyd: (2023-06-01)

NMR Methods to Study Dynamic Allostery.
gan: Sarina Grutsch, et al.
Cyhoeddwyd: (2016-03-01)

Ack1: activation and regulation by allostery.
gan: Ketan S Gajiwala, et al.
Cyhoeddwyd: (2013-01-01)

Author Correction: Allostery can convert binding free energies into concerted domain motions in enzymes
gan: Nicole Stéphanie Galenkamp, et al.
Cyhoeddwyd: (2025-01-01)

Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions
gan: Noboru Ishiyama, et al.
Cyhoeddwyd: (2018-11-01)

Designing allostery-inspired response in mechanical networks
gan: Rocks, Jason W., et al.
Cyhoeddwyd: (2017)

Investigating potential allostery in the transcription factor CREB
gan: Chung, NL
Cyhoeddwyd: (2020)

HIV-1 Envelope Conformation, Allostery, and Dynamics
gan: Ashley Lauren Bennett, et al.
Cyhoeddwyd: (2021-05-01)

Allostery and Epistasis: Emergent Properties of Anisotropic Networks
gan: Paul Campitelli, et al.
Cyhoeddwyd: (2020-06-01)

Structural Basis for Allostery in PLP-dependent Enzymes
gan: Jenny U. Tran, et al.
Cyhoeddwyd: (2022-04-01)

Insights into the molecular mechanism of allostery in Hsp70s
gan: Matthias Peter Mayer, et al.
Cyhoeddwyd: (2015-10-01)

A unified view of "how allostery works".
gan: Chung-Jung Tsai, et al.
Cyhoeddwyd: (2014-02-01)

Cellulose-specific Type B carbohydrate binding modules: understanding oligomeric and non-crystalline substrate recognition mechanisms
gan: Abhishek A. Kognole, et al.
Cyhoeddwyd: (2018-11-01)

Dissecting FOXP2 oligomerization and DNA binding
gan: Haeussermann, K, et al.
Cyhoeddwyd: (2019)

Computational modeling of ErbB kinase oligomeric state.
gan: Lim, Sing Mei.
Cyhoeddwyd: (2010)

Dissecting the Determinants of Domain Insertion Tolerance and Allostery in Proteins
gan: Jan Mathony, et al.
Cyhoeddwyd: (2023-10-01)

Advances in the allostery of angiotensin II type 1 receptor
gan: Xi Zhang, et al.
Cyhoeddwyd: (2023-06-01)

Allostery: An Overview of Its History, Concepts, Methods, and Applications.
gan: Jin Liu, et al.
Cyhoeddwyd: (2016-06-01)

Structural insight into substrate and product binding in an archaeal mevalonate kinase.
gan: Bradley R Miller, et al.
Cyhoeddwyd: (2018-01-01)