Leprosy: treatment, prevention, immune response and gene function
Since the leprosy cases have fallen dramatically, the incidence of leprosy has remained stable over the past years, indicating that multidrug therapy seems unable to eradicate leprosy. More seriously, the emergence of rifampicin-resistant strains also affects the effectiveness of treatment. Immunopr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1298749/full |
| _version_ | 1797303372460589056 |
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| author | Xiang Li Yun Ma Guoli Li Guangjie Jin Li Xu Yunhui Li Pingmin Wei Lianhua Zhang Lianhua Zhang |
| author_facet | Xiang Li Yun Ma Guoli Li Guangjie Jin Li Xu Yunhui Li Pingmin Wei Lianhua Zhang Lianhua Zhang |
| author_sort | Xiang Li |
| collection | DOAJ |
| description | Since the leprosy cases have fallen dramatically, the incidence of leprosy has remained stable over the past years, indicating that multidrug therapy seems unable to eradicate leprosy. More seriously, the emergence of rifampicin-resistant strains also affects the effectiveness of treatment. Immunoprophylaxis was mainly carried out through vaccination with the BCG but also included vaccines such as LepVax and MiP. Meanwhile, it is well known that the infection and pathogenesis largely depend on the host’s genetic background and immunity, with the onset of the disease being genetically regulated. The immune process heavily influences the clinical course of the disease. However, the impact of immune processes and genetic regulation of leprosy on pathogenesis and immunological levels is largely unknown. Therefore, we summarize the latest research progress in leprosy treatment, prevention, immunity and gene function. The comprehensive research in these areas will help elucidate the pathogenesis of leprosy and provide a basis for developing leprosy elimination strategies. |
| first_indexed | 2024-03-07T23:51:47Z |
| format | Article |
| id | doaj.art-2e73fa6788bf48efab4fd191d6515ded |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-07T23:51:47Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2e73fa6788bf48efab4fd191d6515ded2024-02-19T04:29:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.12987491298749Leprosy: treatment, prevention, immune response and gene functionXiang Li0Yun Ma1Guoli Li2Guangjie Jin3Li Xu4Yunhui Li5Pingmin Wei6Lianhua Zhang7Lianhua Zhang8Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, ChinaChronic Infectious Disease Control Section, Nantong Center for Disease Control and Prevention, Nantong, ChinaDepartment of Chronic Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, ChinaDepartment of Chronic Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, ChinaDepartment of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, ChinaDepartment of Chronic Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, ChinaSince the leprosy cases have fallen dramatically, the incidence of leprosy has remained stable over the past years, indicating that multidrug therapy seems unable to eradicate leprosy. More seriously, the emergence of rifampicin-resistant strains also affects the effectiveness of treatment. Immunoprophylaxis was mainly carried out through vaccination with the BCG but also included vaccines such as LepVax and MiP. Meanwhile, it is well known that the infection and pathogenesis largely depend on the host’s genetic background and immunity, with the onset of the disease being genetically regulated. The immune process heavily influences the clinical course of the disease. However, the impact of immune processes and genetic regulation of leprosy on pathogenesis and immunological levels is largely unknown. Therefore, we summarize the latest research progress in leprosy treatment, prevention, immunity and gene function. The comprehensive research in these areas will help elucidate the pathogenesis of leprosy and provide a basis for developing leprosy elimination strategies.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1298749/fullleprosyMDTprophylaxisrifapentineimmune cellssusceptibility gene |
| spellingShingle | Xiang Li Yun Ma Guoli Li Guangjie Jin Li Xu Yunhui Li Pingmin Wei Lianhua Zhang Lianhua Zhang Leprosy: treatment, prevention, immune response and gene function Frontiers in Immunology leprosy MDT prophylaxis rifapentine immune cells susceptibility gene |
| title | Leprosy: treatment, prevention, immune response and gene function |
| title_full | Leprosy: treatment, prevention, immune response and gene function |
| title_fullStr | Leprosy: treatment, prevention, immune response and gene function |
| title_full_unstemmed | Leprosy: treatment, prevention, immune response and gene function |
| title_short | Leprosy: treatment, prevention, immune response and gene function |
| title_sort | leprosy treatment prevention immune response and gene function |
| topic | leprosy MDT prophylaxis rifapentine immune cells susceptibility gene |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1298749/full |
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