Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response
Background: Flecainide is an antiarrhythmic agent that is used primarily in the treatment of cardiac arrhythmias. Some evidences also suggest that flecainide can participate in alveolar fluid clearance and inflammatory responses. This experiment was aimed to evaluate the effects of flecainide on sep...
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| Format: | Article |
| Language: | English |
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Korean Society of Critical Care Medicine
2016-08-01
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| Series: | Korean Journal of Critical Care Medicine |
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| Online Access: | http://www.kjccm.org/upload/pdf/kjccm-2016-00157.pdf |
| _version_ | 1818200706701590528 |
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| author | Jia Song Young joong Suh Hyun jung Lee Eun a Jang Hong-beom Bae Sang-Hyun Kwak |
| author_facet | Jia Song Young joong Suh Hyun jung Lee Eun a Jang Hong-beom Bae Sang-Hyun Kwak |
| author_sort | Jia Song |
| collection | DOAJ |
| description | Background: Flecainide is an antiarrhythmic agent that is used primarily in the treatment of cardiac arrhythmias. Some evidences also suggest that flecainide can participate in alveolar fluid clearance and inflammatory responses. This experiment was aimed to evaluate the effects of flecainide on sepsis induced acute lung injury in a rat model. Methods: Rats were treated with subcutaneous infusion of saline or flecainide (0.1 or 0.2 mg/kg/hr) by a mini-osmotic pump. Subcutaneous infusion was started 3 hours before and continued until 8 hours after intraperitoneal injection of saline or endotoxin. Animals were sacrificed for analyses of severity of acute lung injury with wet to dry (W/D) ratio and lung injury score (LIS) in lung and inflammatory responses with level of leukocyte, polymorphonuclear neutrophils (PMNs) and inteleukin-8 (IL-8) in bronchoalveolar lavages fluid (BALF). Results: Flecainide markedly improved dose dependently sepsis induced acute lung injury as analysed by W/D ratio (from 2.24 ± 0.11 to 1.76 ± 0.09, p < 0.05) and LIS (from 3 to 1, p < 0.05), and inflammatory response as determined by leukocyte (from 443 ± 127 to 229 ± 95, p < 0.05), PMNs (from 41.43 ± 17.63 to 2.43 ± 2.61, p < 0.05) and IL-8 (from 95.00 ± 15.28 to 40.00 ± 10.21, p < 0.05) in BALF. Conclusions: Flecanide improve sepsis induced acute lung injury in rats by controlling inflammatory responses. |
| first_indexed | 2024-12-12T02:41:56Z |
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| id | doaj.art-2e744755bf5245fab341c1e81ae9a170 |
| institution | Directory Open Access Journal |
| issn | 2383-4870 2383-4889 |
| language | English |
| last_indexed | 2024-12-12T02:41:56Z |
| publishDate | 2016-08-01 |
| publisher | Korean Society of Critical Care Medicine |
| record_format | Article |
| series | Korean Journal of Critical Care Medicine |
| spelling | doaj.art-2e744755bf5245fab341c1e81ae9a1702022-12-22T00:41:08ZengKorean Society of Critical Care MedicineKorean Journal of Critical Care Medicine2383-48702383-48892016-08-0131319420110.4266/kjccm.2016.001571036Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory ResponseJia Song0Young joong Suh1Hyun jung Lee2Eun a Jang3Hong-beom Bae4Sang-Hyun Kwak5 Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Korea Department of Anesthesiology and Pain Medicine, Gwangju Christian Hospital, Gwangju, Korea Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Korea Department of Anesthesiology and Pain Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea Department of Anesthesiology and Pain Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea Department of Anesthesiology and Pain Medicine, Chonnam National University Hospital, Chonnam National University Medical School, KoreaBackground: Flecainide is an antiarrhythmic agent that is used primarily in the treatment of cardiac arrhythmias. Some evidences also suggest that flecainide can participate in alveolar fluid clearance and inflammatory responses. This experiment was aimed to evaluate the effects of flecainide on sepsis induced acute lung injury in a rat model. Methods: Rats were treated with subcutaneous infusion of saline or flecainide (0.1 or 0.2 mg/kg/hr) by a mini-osmotic pump. Subcutaneous infusion was started 3 hours before and continued until 8 hours after intraperitoneal injection of saline or endotoxin. Animals were sacrificed for analyses of severity of acute lung injury with wet to dry (W/D) ratio and lung injury score (LIS) in lung and inflammatory responses with level of leukocyte, polymorphonuclear neutrophils (PMNs) and inteleukin-8 (IL-8) in bronchoalveolar lavages fluid (BALF). Results: Flecainide markedly improved dose dependently sepsis induced acute lung injury as analysed by W/D ratio (from 2.24 ± 0.11 to 1.76 ± 0.09, p < 0.05) and LIS (from 3 to 1, p < 0.05), and inflammatory response as determined by leukocyte (from 443 ± 127 to 229 ± 95, p < 0.05), PMNs (from 41.43 ± 17.63 to 2.43 ± 2.61, p < 0.05) and IL-8 (from 95.00 ± 15.28 to 40.00 ± 10.21, p < 0.05) in BALF. Conclusions: Flecanide improve sepsis induced acute lung injury in rats by controlling inflammatory responses.http://www.kjccm.org/upload/pdf/kjccm-2016-00157.pdflung injurycytokineflecainideleukocytesepsis |
| spellingShingle | Jia Song Young joong Suh Hyun jung Lee Eun a Jang Hong-beom Bae Sang-Hyun Kwak Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response Korean Journal of Critical Care Medicine lung injury cytokine flecainide leukocyte sepsis |
| title | Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response |
| title_full | Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response |
| title_fullStr | Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response |
| title_full_unstemmed | Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response |
| title_short | Flecainide Improve Sepsis Induced Acute Lung Injury by Controlling Inflammatory Response |
| title_sort | flecainide improve sepsis induced acute lung injury by controlling inflammatory response |
| topic | lung injury cytokine flecainide leukocyte sepsis |
| url | http://www.kjccm.org/upload/pdf/kjccm-2016-00157.pdf |
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