The Morphological and Dynamic Changes of Ultrasound in the Evaluation of Effects of Oral Steroids Treatment for Patients with Carpal Tunnel Syndrome
The role of oral steroids in carpal tunnel syndrome (CTS) remains elusive. This study aims to depict the ultrasound findings and conceivable mechanisms in relation to the efficacy of oral steroids for patients with CTS by measuring the morphological and motion changes in the median nerve. In this st...
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MDPI AG
2021-07-01
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| Online Access: | https://www.mdpi.com/2075-4418/11/8/1336 |
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| author | Yun-Chain Yau Chun-Pai Yang Ching-Po Lin I-Ju Tsai Ching-Mao Chang Cheng-Chia Yang Po-Hsuan Shih Yin-Yin Liao |
| author_facet | Yun-Chain Yau Chun-Pai Yang Ching-Po Lin I-Ju Tsai Ching-Mao Chang Cheng-Chia Yang Po-Hsuan Shih Yin-Yin Liao |
| author_sort | Yun-Chain Yau |
| collection | DOAJ |
| description | The role of oral steroids in carpal tunnel syndrome (CTS) remains elusive. This study aims to depict the ultrasound findings and conceivable mechanisms in relation to the efficacy of oral steroids for patients with CTS by measuring the morphological and motion changes in the median nerve. In this study, CTS patients were randomized to the oral steroid group (14 participants and 22 wrists) or nicergoline group (22 participants and 35 wrists) for 4 weeks. Both treatment arms were given global symptom score (GSS) measurements and completed an ultra-sound at baseline and at 2- and 4-weeks post-treatment. In the nerve conduction study (NCS), distal motor latency (DML) was used to assess the treatment response at baseline and 4 weeks post-treatment. The cross-sectional area (CSA) and amplitude (AMP) evaluated by the maximum lateral sliding displacement represented the morphological and dynamic changes in the median nerve, respectively. The results showed that AMP, CSA, GSS, and DML were significantly im-proved in the steroid group, as compared to the nicergoline group at weeks 2 and 4 (<i>p</i> < 0.05). The mean improvement in ultrasound parameters CSA (15.03% reduction) and AMP (466.09% increase) was better than the DML (7.88% reduction) parameter of NCS, and ultrasound changes were detectable as early as 2 weeks after oral steroid administration. Ultrasounds can serve as a tool for the quantitative measurement of treatment effects and can potentially elucidate the pathogenesis of CTS in a non-invasive and more effective manner. |
| first_indexed | 2024-03-10T08:53:21Z |
| format | Article |
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| language | English |
| last_indexed | 2024-03-10T08:53:21Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-2e77d2e9ffed4e918a618abb31dfe7162023-11-22T07:19:03ZengMDPI AGDiagnostics2075-44182021-07-01118133610.3390/diagnostics11081336The Morphological and Dynamic Changes of Ultrasound in the Evaluation of Effects of Oral Steroids Treatment for Patients with Carpal Tunnel SyndromeYun-Chain Yau0Chun-Pai Yang1Ching-Po Lin2I-Ju Tsai3Ching-Mao Chang4Cheng-Chia Yang5Po-Hsuan Shih6Yin-Yin Liao7Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, TaiwanDepartment of Neurology, Kuang Tien General Hospital, Taichung 433, TaiwanDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 112, TaiwanDepartment of Medical Research, Kuang Tien General Hospital, Taichung 433, TaiwanCenter for Traditional Medicine, Taipei Veterans General Hospital, Taipei 112, TaiwanDepartment of Healthcare Administration, Asia University, Taichung 413, TaiwanInstitute of Traditional Medicine, National Yang Ming Chiao Tung University, Taipei 112, TaiwanDepartment of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 402, TaiwanThe role of oral steroids in carpal tunnel syndrome (CTS) remains elusive. This study aims to depict the ultrasound findings and conceivable mechanisms in relation to the efficacy of oral steroids for patients with CTS by measuring the morphological and motion changes in the median nerve. In this study, CTS patients were randomized to the oral steroid group (14 participants and 22 wrists) or nicergoline group (22 participants and 35 wrists) for 4 weeks. Both treatment arms were given global symptom score (GSS) measurements and completed an ultra-sound at baseline and at 2- and 4-weeks post-treatment. In the nerve conduction study (NCS), distal motor latency (DML) was used to assess the treatment response at baseline and 4 weeks post-treatment. The cross-sectional area (CSA) and amplitude (AMP) evaluated by the maximum lateral sliding displacement represented the morphological and dynamic changes in the median nerve, respectively. The results showed that AMP, CSA, GSS, and DML were significantly im-proved in the steroid group, as compared to the nicergoline group at weeks 2 and 4 (<i>p</i> < 0.05). The mean improvement in ultrasound parameters CSA (15.03% reduction) and AMP (466.09% increase) was better than the DML (7.88% reduction) parameter of NCS, and ultrasound changes were detectable as early as 2 weeks after oral steroid administration. Ultrasounds can serve as a tool for the quantitative measurement of treatment effects and can potentially elucidate the pathogenesis of CTS in a non-invasive and more effective manner.https://www.mdpi.com/2075-4418/11/8/1336carpal tunnel syndromesteroidultrasoundcross-sectional areaamplitude |
| spellingShingle | Yun-Chain Yau Chun-Pai Yang Ching-Po Lin I-Ju Tsai Ching-Mao Chang Cheng-Chia Yang Po-Hsuan Shih Yin-Yin Liao The Morphological and Dynamic Changes of Ultrasound in the Evaluation of Effects of Oral Steroids Treatment for Patients with Carpal Tunnel Syndrome Diagnostics carpal tunnel syndrome steroid ultrasound cross-sectional area amplitude |
| title | The Morphological and Dynamic Changes of Ultrasound in the Evaluation of Effects of Oral Steroids Treatment for Patients with Carpal Tunnel Syndrome |
| title_full | The Morphological and Dynamic Changes of Ultrasound in the Evaluation of Effects of Oral Steroids Treatment for Patients with Carpal Tunnel Syndrome |
| title_fullStr | The Morphological and Dynamic Changes of Ultrasound in the Evaluation of Effects of Oral Steroids Treatment for Patients with Carpal Tunnel Syndrome |
| title_full_unstemmed | The Morphological and Dynamic Changes of Ultrasound in the Evaluation of Effects of Oral Steroids Treatment for Patients with Carpal Tunnel Syndrome |
| title_short | The Morphological and Dynamic Changes of Ultrasound in the Evaluation of Effects of Oral Steroids Treatment for Patients with Carpal Tunnel Syndrome |
| title_sort | morphological and dynamic changes of ultrasound in the evaluation of effects of oral steroids treatment for patients with carpal tunnel syndrome |
| topic | carpal tunnel syndrome steroid ultrasound cross-sectional area amplitude |
| url | https://www.mdpi.com/2075-4418/11/8/1336 |
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