Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer

Low expression of miR-29a is associated with aggressive biology and worse survival in gastric cancer

Abstract Advanced gastric cancer (GC) is one of the most lethal cancer types, thus a better understanding of its biology in patients is urgently needed. MicroRNA (miR)-29a is a known tumor suppressive miR that is related to metastasis, but its clinical relevance in GC remains ambiguous. Here, using...

Full description

Bibliographic Details
Main Authors:	Yoshihisa Tokumaru, Masanori Oshi, Michelle R. Huyser, Li Yan, Masahiro Fukada, Nobuhisa Matsuhashi, Manabu Futamura, Yukihiro Akao, Kazuhiro Yoshida, Kazuaki Takabe
Format:	Article
Language:	English
Published:	Nature Portfolio 2021-07-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-021-93681-z

Similar Items

Organoids Are Limited in Modeling the Colon Adenoma–Carcinoma Sequence
by: Yoshihisa Tokumaru, et al.
Published: (2021-02-01)

M1 Macrophage and M1/M2 ratio defined by transcriptomic signatures resemble only part of their conventional clinical characteristics in breast cancer
by: Masanori Oshi, et al.
Published: (2020-10-01)

Inflammation Is Associated with Worse Outcome in the Whole Cohort but with Better Outcome in Triple-Negative Subtype of Breast Cancer Patients
by: Masanori Oshi, et al.
Published: (2020-01-01)

Adipogenesis in triple-negative breast cancer is associated with unfavorable tumor immune microenvironment and with worse survival
by: Masanori Oshi, et al.
Published: (2021-06-01)

Application of an artificial intelligence-based system in the diagnosis of breast ultrasound images obtained using a smartphone
by: Ryutaro Mori, et al.
Published: (2024-01-01)

Enhanced immune response outperform aggressive cancer biology and is associated with better survival in triple-negative breast cancer
by: Masanori Oshi, et al.
Published: (2022-08-01)

Annexin A1 Expression Is Associated with Epithelial–Mesenchymal Transition (EMT), Cell Proliferation, Prognosis, and Drug Response in Pancreatic Cancer
by: Masanori Oshi, et al.
Published: (2021-03-01)

Clinical Relevance of Estrogen Reactivity in the Breast Cancer Microenvironment
by: Takashi Takeshita, et al.
Published: (2022-05-01)

The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+/HER2− Breast Cancer
by: Masanori Oshi, et al.
Published: (2020-07-01)

Left sided breast cancer is associated with aggressive biology and worse outcomes than right sided breast cancer
by: Yara Abdou, et al.
Published: (2022-08-01)

Biologically Aggressive Phenotype and Anti-cancer Immunity Counterbalance in Breast Cancer with High Mutation Rate
by: Hideo Takahashi, et al.
Published: (2020-02-01)

The mode of progressive disease affects the prognosis of patients with metastatic breast cancer
by: Ryutaro Mori, et al.
Published: (2018-08-01)

Risk and early predictive factors of anastomotic leakage in laparoscopic low anterior resection for rectal cancer
by: Masahiro Fukada, et al.
Published: (2019-11-01)

Prognostic factors in pulmonary metastasectomy and efficacy of repeat pulmonary metastasectomy from colorectal cancer
by: Masahiro Fukada, et al.
Published: (2020-11-01)

MicroRNAs and Their Therapeutic Potential for Human Diseases: MicroRNAs, miR-143 and -145, Function as Anti-oncomirs and the Application of Chemically Modified miR-143 as an Anti-cancer Drug
by: Yukio Kitade, et al.
Published: (2010-01-01)

Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation
by: Jun Arima, et al.
Published: (2023-12-01)

Implication of IZUMO2 in the cell‐in‐cell phenomenon: A potential therapeutic target for triple‐negative breast cancer
by: Toshiya Higashi, et al.
Published: (2024-03-01)

Adiponectin‐expressing Treg‐containing T cell fraction inhibits tumor growth in orthotopically implanted triple‐negative breast cancer
by: Wakana Chikaishi, et al.
Published: (2023-10-01)

Gastric carcinosarcoma with FGFR2 amplification under long-term control with pazopanib: a case report and literature review
by: Hirokatsu Hayashi, et al.
Published: (2022-07-01)

Chemically modified MIR143-3p exhibited anti-cancer effects by impairing the KRAS network in colorectal cancer cells
by: Nobuhiko Sugito, et al.
Published: (2022-12-01)

The low expression of miR-451 predicts a worse prognosis in non-small cell lung cancer cases.
by: Akiteru Goto, et al.
Published: (2017-01-01)

Potential activity of adiponectin‐expressing regulatory T cells against triple‐negative breast cancer cells through the cell‐in‐cell phenomenon
by: Wakana Chikaishi, et al.
Published: (2023-07-01)

Worse and Worse and Worse: Essential Tremor Patients’ Longitudinal Perspectives on their Condition
by: Jesus Gutierrez, et al.
Published: (2016-10-01)

c-Myc Represses Tumor-Suppressive microRNAs, let-7a, miR-16 and miR-29b, and Induces Cyclin D2-Mediated Cell Proliferation in Ewing's Sarcoma Cell Line.
by: Masanori Kawano, et al.
Published: (2015-01-01)

Paradoxical Association of Postoperative Plasma Sphingosine-1-Phosphate with Breast Cancer Aggressiveness and Chemotherapy
by: Rajesh Ramanathan, et al.
Published: (2017-01-01)

Similar Prognosis of Patients with Bone-only Metastatic Breast Cancer and Visceral Metastasis
by: Ryutaro Mori, et al.
Published: (2021-01-01)

Downregulation of MIR-145 predicts a worse outcome in upper tract urothelial carcinomas
by: Hung-Lung Ke, et al.
Published: (2015-12-01)

Circulating miR-21, miR-29a, and miR-126 are associated with premature death risk due to cancer and cardiovascular disease: the JACC Study
by: Hiroya Yamada, et al.
Published: (2021-03-01)

Late recurrent gastric carcinoma 12 years after surgery with attenuation of CD44 variant 9 expression
by: Hirokatsu Hayashi, et al.
Published: (2023-05-01)

The miR-29 family in hematological malignancies
by: Barbora Fiserova, et al.
Published: (2015-06-01)

Aryl hydrocarbon receptor suppresses STING-mediated type I IFN expression in triple-negative breast cancer
by: Jeffrey C. Martin, et al.
Published: (2024-03-01)

For better, for worse /
by: Matthews, Carole, author
Published: (2000)

For Better or Worse
by: Sinenhlanhla Sithulisiwe Chisale
Published: (2016-07-01)

The diagnosis of a metastatic breast tumor from ovarian cancer by the succession of a p53 mutation: a case report
by: Ryutaro Mori, et al.
Published: (2017-06-01)

Worse Caries Experience Does Not Lead to Worse Overall Health
by: Indiara Welter Henn, et al.
Published: (2021-11-01)

Perioperative predictive factors of failure to rescue following highly advanced hepatobiliary-pancreatic surgery: a single-institution retrospective study
by: Masahiro Fukada, et al.
Published: (2023-11-01)

Development of a novel BRCAness score that predicts response to PARP inhibitors
by: Masanori Oshi, et al.
Published: (2022-11-01)

An endoscopic dilation method using the rendezvous approach for the treatment of severe anastomotic stenosis after rectal cancer surgery: a case report
by: Takuya Nakashima, et al.
Published: (2020-11-01)

The Role of miR-29s in Human Cancers—An Update
by: Thuy T. P. Nguyen, et al.
Published: (2022-08-01)

A Systematic Review of miR-29 in Cancer
by: Jason J. Kwon, et al.
Published: (2019-03-01)