Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant
This study aimed to screen an effective flavonoid with promising whitening and antioxidant capacities, and design flavonoid-loaded niosomes to improve its solubility, stability, and penetration. In vitro anti-tyrosinase and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging experiments wer...
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| Format: | Article |
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MDPI AG
2019-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/24/12/2322 |
| _version_ | 1817992049949933568 |
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| author | Banyi Lu Yanting Huang Zhongyun Chen Jingyi Ye Hongyu Xu Wenrong Chen Xiaoying Long |
| author_facet | Banyi Lu Yanting Huang Zhongyun Chen Jingyi Ye Hongyu Xu Wenrong Chen Xiaoying Long |
| author_sort | Banyi Lu |
| collection | DOAJ |
| description | This study aimed to screen an effective flavonoid with promising whitening and antioxidant capacities, and design flavonoid-loaded niosomes to improve its solubility, stability, and penetration. In vitro anti-tyrosinase and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging experiments were conducted to investigate the whitening and antioxidant capacities of several flavonoids, including quercetin, morin, festin, myricetin, rutin, and breviscapine. The conductivity, viscosity, and particle size of Span60-RH40-based formulation of nonionic surfactant vesicles (niosomes) with different mass ratios were studied to determine the most appropriate formulation. Drug-loaded niosomes were characterized for size, zeta potential, morphology, and entrapment efficiency. The photostability, solubility, release behavior, ex vivo drug penetration, and skin retention were also studied. The results showed that quercetin has considerable whitening and antioxidant capacities and Span60-RH40 at a mass ratio of 9:11 forms spherical or oval niosomes of 97.6 ± 3.1 nm with a zeta potential range of 31.1 ± 0.9 mV, and drug entrapment efficiency as high as 87.3 ± 1.6%. Niosomes remarkably improved the solubility and photostability of quercetin. Furthermore, compared to quercetin solution, quercetin-niosomes had the advantages of sustained release and improved transdermal penetration, with skin retention 2.95 times higher than quercetin solution. |
| first_indexed | 2024-04-14T01:21:26Z |
| format | Article |
| id | doaj.art-2e799fcdfead4d1b865a944f76db0922 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-14T01:21:26Z |
| publishDate | 2019-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-2e799fcdfead4d1b865a944f76db09222022-12-22T02:20:37ZengMDPI AGMolecules1420-30492019-06-012412232210.3390/molecules24122322molecules24122322Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and AntioxidantBanyi Lu0Yanting Huang1Zhongyun Chen2Jingyi Ye3Hongyu Xu4Wenrong Chen5Xiaoying Long6School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaDepartment of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaDepartment of Pharmaceutics, School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaResearch and Development Center, Sirio Pharma Co., Ltd, Shantou 515041, ChinaSchool of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, ChinaThis study aimed to screen an effective flavonoid with promising whitening and antioxidant capacities, and design flavonoid-loaded niosomes to improve its solubility, stability, and penetration. In vitro anti-tyrosinase and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging experiments were conducted to investigate the whitening and antioxidant capacities of several flavonoids, including quercetin, morin, festin, myricetin, rutin, and breviscapine. The conductivity, viscosity, and particle size of Span60-RH40-based formulation of nonionic surfactant vesicles (niosomes) with different mass ratios were studied to determine the most appropriate formulation. Drug-loaded niosomes were characterized for size, zeta potential, morphology, and entrapment efficiency. The photostability, solubility, release behavior, ex vivo drug penetration, and skin retention were also studied. The results showed that quercetin has considerable whitening and antioxidant capacities and Span60-RH40 at a mass ratio of 9:11 forms spherical or oval niosomes of 97.6 ± 3.1 nm with a zeta potential range of 31.1 ± 0.9 mV, and drug entrapment efficiency as high as 87.3 ± 1.6%. Niosomes remarkably improved the solubility and photostability of quercetin. Furthermore, compared to quercetin solution, quercetin-niosomes had the advantages of sustained release and improved transdermal penetration, with skin retention 2.95 times higher than quercetin solution.https://www.mdpi.com/1420-3049/24/12/2322anti-tyrosinaseantioxidantniosomesphotostabilitytransdermal delivery |
| spellingShingle | Banyi Lu Yanting Huang Zhongyun Chen Jingyi Ye Hongyu Xu Wenrong Chen Xiaoying Long Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant Molecules anti-tyrosinase antioxidant niosomes photostability transdermal delivery |
| title | Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant |
| title_full | Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant |
| title_fullStr | Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant |
| title_full_unstemmed | Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant |
| title_short | Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant |
| title_sort | niosomal nanocarriers for enhanced skin delivery of quercetin with functions of anti tyrosinase and antioxidant |
| topic | anti-tyrosinase antioxidant niosomes photostability transdermal delivery |
| url | https://www.mdpi.com/1420-3049/24/12/2322 |
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