Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD)
Abstract Background Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sede...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-10-01
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| Series: | International Journal of Behavioral Nutrition and Physical Activity |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12966-019-0858-6 |
| _version_ | 1818049172090126336 |
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| author | Katrien Wijndaele Thomas White Lars Bo Andersen Anna Bugge Elin Kolle Kate Northstone Niels Wedderkopp Mathias Ried-Larsen Susi Kriemler Angie S. Page Jardena J. Puder John J. Reilly Luis B. Sardinha Esther M. F. van Sluijs Stephen J. Sharp Søren Brage Ulf Ekelund On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators |
| author_facet | Katrien Wijndaele Thomas White Lars Bo Andersen Anna Bugge Elin Kolle Kate Northstone Niels Wedderkopp Mathias Ried-Larsen Susi Kriemler Angie S. Page Jardena J. Puder John J. Reilly Luis B. Sardinha Esther M. F. van Sluijs Stephen J. Sharp Søren Brage Ulf Ekelund On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators |
| author_sort | Katrien Wijndaele |
| collection | DOAJ |
| description | Abstract Background Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children. Methods Cross-sectional data from 14 studies (7 countries) in the International Children’s Accelerometry Database (ICAD, 1998–2009) was included. Accelerometry in 19,502 participants aged 3–18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed. Results Modelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (− 0.44 (− 0.62; − 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (− 3.07 (− 4.47; − 1.68) cm), systolic blood pressure (− 1.53 (− 2.42; − 0.65) mmHg) and clustered cardio-metabolic risk (− 0.18 (− 0.3; − 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: − 0.81 (− 1.38; − 0.24) mmHg). Conclusions Replacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates. |
| first_indexed | 2024-12-10T10:33:21Z |
| format | Article |
| id | doaj.art-2e7a59d4388a408e8a50ef5bf42ba31c |
| institution | Directory Open Access Journal |
| issn | 1479-5868 |
| language | English |
| last_indexed | 2024-12-10T10:33:21Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Behavioral Nutrition and Physical Activity |
| spelling | doaj.art-2e7a59d4388a408e8a50ef5bf42ba31c2022-12-22T01:52:30ZengBMCInternational Journal of Behavioral Nutrition and Physical Activity1479-58682019-10-0116111010.1186/s12966-019-0858-6Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD)Katrien Wijndaele0Thomas White1Lars Bo Andersen2Anna Bugge3Elin Kolle4Kate Northstone5Niels Wedderkopp6Mathias Ried-Larsen7Susi Kriemler8Angie S. Page9Jardena J. Puder10John J. Reilly11Luis B. Sardinha12Esther M. F. van Sluijs13Stephen J. Sharp14Søren Brage15Ulf Ekelund16On behalf of the International Children’s Accelerometry Database (ICAD) CollaboratorsMRC Epidemiology Unit, Institute of Metabolic Science, University of CambridgeMRC Epidemiology Unit, Institute of Metabolic Science, University of CambridgeFaculty of Teacher Education and Sport, Campus Sogndal, Western Norway University of Applied SciencesCentre for Research in Childhood Health, Exercise Epidemiology Unit, Department of Sport Sciences and Clinical Biomechanics, University of Southern DenmarkDepartment of Sport Medicine, Norwegian School of Sport SciencesBristol Medical School, University of BristolFaculty of Teacher Education and Sport, Campus Sogndal, Western Norway University of Applied SciencesFaculty of Teacher Education and Sport, Campus Sogndal, Western Norway University of Applied SciencesInstitute of Social and Preventive Medicine, University of ZurichCentre for Exercise, Nutrition and health Sciences, School for Policy Studies, University of BristolLausanne University HospitalSchool of Psychological Sciences and Health, University of StrathclydeExercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de LisboaMRC Epidemiology Unit, Institute of Metabolic Science, University of CambridgeMRC Epidemiology Unit, Institute of Metabolic Science, University of CambridgeMRC Epidemiology Unit, Institute of Metabolic Science, University of CambridgeDepartment of Sport Medicine, Norwegian School of Sport SciencesAbstract Background Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardio-metabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children. Methods Cross-sectional data from 14 studies (7 countries) in the International Children’s Accelerometry Database (ICAD, 1998–2009) was included. Accelerometry in 19,502 participants aged 3–18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed. Results Modelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (− 0.44 (− 0.62; − 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (− 3.07 (− 4.47; − 1.68) cm), systolic blood pressure (− 1.53 (− 2.42; − 0.65) mmHg) and clustered cardio-metabolic risk (− 0.18 (− 0.3; − 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: − 0.81 (− 1.38; − 0.24) mmHg). Conclusions Replacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.http://link.springer.com/article/10.1186/s12966-019-0858-6ICADALSPACProlonged sittingCardio-metabolicIso-temporalPhysical activity |
| spellingShingle | Katrien Wijndaele Thomas White Lars Bo Andersen Anna Bugge Elin Kolle Kate Northstone Niels Wedderkopp Mathias Ried-Larsen Susi Kriemler Angie S. Page Jardena J. Puder John J. Reilly Luis B. Sardinha Esther M. F. van Sluijs Stephen J. Sharp Søren Brage Ulf Ekelund On behalf of the International Children’s Accelerometry Database (ICAD) Collaborators Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD) International Journal of Behavioral Nutrition and Physical Activity ICAD ALSPAC Prolonged sitting Cardio-metabolic Iso-temporal Physical activity |
| title | Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD) |
| title_full | Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD) |
| title_fullStr | Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD) |
| title_full_unstemmed | Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD) |
| title_short | Substituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD) |
| title_sort | substituting prolonged sedentary time and cardiovascular risk in children and youth a meta analysis within the international children s accelerometry database icad |
| topic | ICAD ALSPAC Prolonged sitting Cardio-metabolic Iso-temporal Physical activity |
| url | http://link.springer.com/article/10.1186/s12966-019-0858-6 |
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