Antiviral Resistance of Splenocytes in Aged Mice
We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. T...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2017-03-01
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| Series: | Polish Journal of Microbiology |
| Subjects: | |
| Online Access: | https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/66/1/pdf/10.5604_17331331.1235002.pdf |
| _version_ | 1811220781532708864 |
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| author | Ewa Zaczyńska Jolanta Artym Maja Kocięba Timo Burster Marian Kruzel Maria Paprocka Michał Zimecki |
| author_facet | Ewa Zaczyńska Jolanta Artym Maja Kocięba Timo Burster Marian Kruzel Maria Paprocka Michał Zimecki |
| author_sort | Ewa Zaczyńska |
| collection | DOAJ |
| description | We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time. |
| first_indexed | 2024-04-12T07:47:29Z |
| format | Article |
| id | doaj.art-2e7bea6a6f684592a60c607b3624a912 |
| institution | Directory Open Access Journal |
| issn | 1733-1331 2544-4646 |
| language | English |
| last_indexed | 2024-04-12T07:47:29Z |
| publishDate | 2017-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Polish Journal of Microbiology |
| spelling | doaj.art-2e7bea6a6f684592a60c607b3624a9122022-12-22T03:41:40ZengSciendoPolish Journal of Microbiology1733-13312544-46462017-03-0166110.5604/17331331.1235002Antiviral Resistance of Splenocytes in Aged MiceEwa Zaczyńska0Jolanta Artym1Maja Kocięba2Timo Burster3Marian Kruzel4Maria Paprocka5Michał Zimecki6Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Department of Experimental Therapy, Wrocław, PolandInstitute of Immunology and Experimental Therapy, Polish Academy of Sciences, Department of Experimental Therapy, Wrocław, PolandInstitute of Immunology and Experimental Therapy, Polish Academy of Sciences, Department of Experimental Therapy, Wrocław, PolandDepartment of Neurosurgery, Ulm University Medical Centre, Ulm, GermanyUniversity of Texas, Houston Medical School, Houston, TX, USAInstitute of Immunology and Experimental Therapy, Polish Academy of Sciences, Department of Experimental Therapy, Wrocław, PolandInstitute of Immunology and Experimental Therapy, Polish Academy of Sciences, Department of Experimental Therapy, Wrocław, PolandWe compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/66/1/pdf/10.5604_17331331.1235002.pdfimmune ageinglactoferrinmicesplenocytesviral resistance |
| spellingShingle | Ewa Zaczyńska Jolanta Artym Maja Kocięba Timo Burster Marian Kruzel Maria Paprocka Michał Zimecki Antiviral Resistance of Splenocytes in Aged Mice Polish Journal of Microbiology immune ageing lactoferrin mice splenocytes viral resistance |
| title | Antiviral Resistance of Splenocytes in Aged Mice |
| title_full | Antiviral Resistance of Splenocytes in Aged Mice |
| title_fullStr | Antiviral Resistance of Splenocytes in Aged Mice |
| title_full_unstemmed | Antiviral Resistance of Splenocytes in Aged Mice |
| title_short | Antiviral Resistance of Splenocytes in Aged Mice |
| title_sort | antiviral resistance of splenocytes in aged mice |
| topic | immune ageing lactoferrin mice splenocytes viral resistance |
| url | https://www.exeley.com/exeley/journals/polish_journal_of_microbiology/66/1/pdf/10.5604_17331331.1235002.pdf |
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