Mammary Defences and Immunity against Mastitis in Sheep
The objectives of this review paper are to present udder defences, including teat of the udder, mammary epithelial cells, leucocytes, immunoglobulins, complement system and chemical antibacterial agents, to describe cooperation and interactions between them and to elaborate on potentials regarding t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/9/10/726 |
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| author | Angeliki I. Katsafadou Antonis P. Politis Vasia S. Mavrogianni Mariana S. Barbagianni Natalia G. C. Vasileiou George C. Fthenakis Ilektra A. Fragkou |
| author_facet | Angeliki I. Katsafadou Antonis P. Politis Vasia S. Mavrogianni Mariana S. Barbagianni Natalia G. C. Vasileiou George C. Fthenakis Ilektra A. Fragkou |
| author_sort | Angeliki I. Katsafadou |
| collection | DOAJ |
| description | The objectives of this review paper are to present udder defences, including teat of the udder, mammary epithelial cells, leucocytes, immunoglobulins, complement system and chemical antibacterial agents, to describe cooperation and interactions between them and to elaborate on potentials regarding their significance in mammary immunisation strategies. The teat of the udder provides initial protection to the mammary gland. The mammary epithelial cells synthesise antibacterial proteins and the leucocytes produce various inflammation mediators (cytokines or chemokines), phagocytose bacteria and recognise antigenic structures. In the mammary gland, four immunoglobulins (IgG1, IgG2, IgM and IgA) have important roles against bacterial pathogens. The complement system is a collection of proteins, participating in the inflammatory process through various pathways. Other components contributing to humoral mammary defence include lactoferrin, lysozyme and the lactoperoxidase/myeloperoxidase systems, as well as oligosaccharides, gangliosides, reactive oxygen species, acute phase proteins (e.g., haptoglobin and serum amyloid A), ribonucleases and a wide range of antimicrobial peptides. Management practices, genetic variations and nutrition can influence mammary defences and should be taken into account in the formulation of prevention strategies against ovine mastitis. |
| first_indexed | 2024-04-13T20:13:32Z |
| format | Article |
| id | doaj.art-2e7f0494e8674e388ff2828d92f43971 |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-04-13T20:13:32Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-2e7f0494e8674e388ff2828d92f439712022-12-22T02:31:46ZengMDPI AGAnimals2076-26152019-09-0191072610.3390/ani9100726ani9100726Mammary Defences and Immunity against Mastitis in SheepAngeliki I. Katsafadou0Antonis P. Politis1Vasia S. Mavrogianni2Mariana S. Barbagianni3Natalia G. C. Vasileiou4George C. Fthenakis5Ilektra A. Fragkou6Veterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceVeterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceVeterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceVeterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceVeterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceVeterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceVeterinary Faculty, University of Thessaly, 43100 Karditsa, GreeceThe objectives of this review paper are to present udder defences, including teat of the udder, mammary epithelial cells, leucocytes, immunoglobulins, complement system and chemical antibacterial agents, to describe cooperation and interactions between them and to elaborate on potentials regarding their significance in mammary immunisation strategies. The teat of the udder provides initial protection to the mammary gland. The mammary epithelial cells synthesise antibacterial proteins and the leucocytes produce various inflammation mediators (cytokines or chemokines), phagocytose bacteria and recognise antigenic structures. In the mammary gland, four immunoglobulins (IgG1, IgG2, IgM and IgA) have important roles against bacterial pathogens. The complement system is a collection of proteins, participating in the inflammatory process through various pathways. Other components contributing to humoral mammary defence include lactoferrin, lysozyme and the lactoperoxidase/myeloperoxidase systems, as well as oligosaccharides, gangliosides, reactive oxygen species, acute phase proteins (e.g., haptoglobin and serum amyloid A), ribonucleases and a wide range of antimicrobial peptides. Management practices, genetic variations and nutrition can influence mammary defences and should be taken into account in the formulation of prevention strategies against ovine mastitis.https://www.mdpi.com/2076-2615/9/10/726eweleucocyteneutrophilsproteomicssubclinical mastitisteatvaccination |
| spellingShingle | Angeliki I. Katsafadou Antonis P. Politis Vasia S. Mavrogianni Mariana S. Barbagianni Natalia G. C. Vasileiou George C. Fthenakis Ilektra A. Fragkou Mammary Defences and Immunity against Mastitis in Sheep Animals ewe leucocyte neutrophils proteomics subclinical mastitis teat vaccination |
| title | Mammary Defences and Immunity against Mastitis in Sheep |
| title_full | Mammary Defences and Immunity against Mastitis in Sheep |
| title_fullStr | Mammary Defences and Immunity against Mastitis in Sheep |
| title_full_unstemmed | Mammary Defences and Immunity against Mastitis in Sheep |
| title_short | Mammary Defences and Immunity against Mastitis in Sheep |
| title_sort | mammary defences and immunity against mastitis in sheep |
| topic | ewe leucocyte neutrophils proteomics subclinical mastitis teat vaccination |
| url | https://www.mdpi.com/2076-2615/9/10/726 |
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