Review: Depression in epilepsy: mechanisms and therapeutic approach
In patients with epilepsy, mood disorders represent a frequent psychiatric comorbidity but they often remain unrecognized and untreated. However, comorbid depression may have a major impact on the quality of life of patients with epilepsy, sometimes even more than the seizures. Among the potential n...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2009-09-01
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| Series: | Therapeutic Advances in Neurological Disorders |
| Online Access: | https://doi.org/10.1177/1756285609337340 |
| _version_ | 1811204116184039424 |
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| author | Marco Mula Bettina Schmitz |
| author_facet | Marco Mula Bettina Schmitz |
| author_sort | Marco Mula |
| collection | DOAJ |
| description | In patients with epilepsy, mood disorders represent a frequent psychiatric comorbidity but they often remain unrecognized and untreated. However, comorbid depression may have a major impact on the quality of life of patients with epilepsy, sometimes even more than the seizures. Among the potential neurobiological and psychosocial determinants, epilepsy-related variables (age at onset of seizures, temporal lobe epilepsy and frequency of seizures) and the antiepileptic drug treatment have been associated with depression. Nonetheless, data on treatment strategies are still limited with a lack of controlled trials on the use of antidepressant drugs. Moreover, the issue of psychotropic drug treatment of depression in epilepsy is interlinked with that of worsening seizures. This paper is aimed at discussing all these subjects in the light of current literature on the neurobiology of depression in epilepsy. |
| first_indexed | 2024-04-12T03:05:57Z |
| format | Article |
| id | doaj.art-2e7fcec83f424417ac0099061a089d1e |
| institution | Directory Open Access Journal |
| issn | 1756-2856 |
| language | English |
| last_indexed | 2024-04-12T03:05:57Z |
| publishDate | 2009-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Neurological Disorders |
| spelling | doaj.art-2e7fcec83f424417ac0099061a089d1e2022-12-22T03:50:29ZengSAGE PublishingTherapeutic Advances in Neurological Disorders1756-28562009-09-01210.1177/1756285609337340Review: Depression in epilepsy: mechanisms and therapeutic approachMarco MulaBettina SchmitzIn patients with epilepsy, mood disorders represent a frequent psychiatric comorbidity but they often remain unrecognized and untreated. However, comorbid depression may have a major impact on the quality of life of patients with epilepsy, sometimes even more than the seizures. Among the potential neurobiological and psychosocial determinants, epilepsy-related variables (age at onset of seizures, temporal lobe epilepsy and frequency of seizures) and the antiepileptic drug treatment have been associated with depression. Nonetheless, data on treatment strategies are still limited with a lack of controlled trials on the use of antidepressant drugs. Moreover, the issue of psychotropic drug treatment of depression in epilepsy is interlinked with that of worsening seizures. This paper is aimed at discussing all these subjects in the light of current literature on the neurobiology of depression in epilepsy.https://doi.org/10.1177/1756285609337340 |
| spellingShingle | Marco Mula Bettina Schmitz Review: Depression in epilepsy: mechanisms and therapeutic approach Therapeutic Advances in Neurological Disorders |
| title | Review: Depression in epilepsy: mechanisms and therapeutic approach |
| title_full | Review: Depression in epilepsy: mechanisms and therapeutic approach |
| title_fullStr | Review: Depression in epilepsy: mechanisms and therapeutic approach |
| title_full_unstemmed | Review: Depression in epilepsy: mechanisms and therapeutic approach |
| title_short | Review: Depression in epilepsy: mechanisms and therapeutic approach |
| title_sort | review depression in epilepsy mechanisms and therapeutic approach |
| url | https://doi.org/10.1177/1756285609337340 |
| work_keys_str_mv | AT marcomula reviewdepressioninepilepsymechanismsandtherapeuticapproach AT bettinaschmitz reviewdepressioninepilepsymechanismsandtherapeuticapproach |