Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience

Ignazio La Mantia, Attilio Varricchio, Giorgio Ciprandi Associazione Italiana Vie Aeree Superiori, Naples, Italy Abstract: Recurrence of acute otitis media (RAOM) is a relevant issue in the clinical practice. “Bacteriotherapy” has been proposed as an option in c...

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Main Authors: La Mantia I, Varricchio A, Ciprandi G
Format: Article
Language:English
Published: Dove Medical Press 2017-06-01
Series:International Journal of General Medicine
Subjects:
Online Access:https://www.dovepress.com/bacteriotherapy-with-streptococcus-salivarius-24smb-and-streptococcus--peer-reviewed-article-IJGM
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author La Mantia I
Varricchio A
Ciprandi G
author_facet La Mantia I
Varricchio A
Ciprandi G
author_sort La Mantia I
collection DOAJ
description Ignazio La Mantia, Attilio Varricchio, Giorgio Ciprandi Associazione Italiana Vie Aeree Superiori, Naples, Italy Abstract: Recurrence of acute otitis media (RAOM) is a relevant issue in the clinical practice. “Bacteriotherapy” has been proposed as an option in children with RAOM. Streptococcus salivarius 24SMB nasal spray has been previously demonstrated to reduce the risk of acute otitis media (AOM) in otitis-prone children. The current retrospective and observational study aimed to confirm this outcome in a real-life setting, such as the common pediatric practice. Group A (108 children) served as control; group B (159 children) was treated with S. salivarius 24SMB and Streptococcus oralis 89a nasal spray after the first AOM episode. Active treatment consisted of 3 monthly courses: 2 puffs per nostril twice/day for a week. Group B showed a significant reduction of AOM episodes in comparison with group A (p<0.0001). Notably, all actively treated children with the highest AOM recurrence had a reduction of recurrence, whereas only 50% of the control group children had reduced RAOM (p<0.0001). Also, severity grade of AOM significantly diminished after the preventive bacteriotherapy (p<0.0001). In conclusion, the current retrospective and observational study demonstrated that S. salivarius 24SMB and S. oralis 89a nasal spray could be effective in the prevention of RAOM in a real-life setting. Keywords: recurrent acute otitis media, bacteriotherapy, Streptococcus salivarius 24SMB, Streptococcus oralis 89a, nasal spray, children
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spelling doaj.art-2e8211227c134088aafc5a395afd926f2022-12-21T17:45:48ZengDove Medical PressInternational Journal of General Medicine1178-70742017-06-01Volume 1017117533351Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experienceLa Mantia IVarricchio ACiprandi GIgnazio La Mantia, Attilio Varricchio, Giorgio Ciprandi Associazione Italiana Vie Aeree Superiori, Naples, Italy Abstract: Recurrence of acute otitis media (RAOM) is a relevant issue in the clinical practice. “Bacteriotherapy” has been proposed as an option in children with RAOM. Streptococcus salivarius 24SMB nasal spray has been previously demonstrated to reduce the risk of acute otitis media (AOM) in otitis-prone children. The current retrospective and observational study aimed to confirm this outcome in a real-life setting, such as the common pediatric practice. Group A (108 children) served as control; group B (159 children) was treated with S. salivarius 24SMB and Streptococcus oralis 89a nasal spray after the first AOM episode. Active treatment consisted of 3 monthly courses: 2 puffs per nostril twice/day for a week. Group B showed a significant reduction of AOM episodes in comparison with group A (p<0.0001). Notably, all actively treated children with the highest AOM recurrence had a reduction of recurrence, whereas only 50% of the control group children had reduced RAOM (p<0.0001). Also, severity grade of AOM significantly diminished after the preventive bacteriotherapy (p<0.0001). In conclusion, the current retrospective and observational study demonstrated that S. salivarius 24SMB and S. oralis 89a nasal spray could be effective in the prevention of RAOM in a real-life setting. Keywords: recurrent acute otitis media, bacteriotherapy, Streptococcus salivarius 24SMB, Streptococcus oralis 89a, nasal spray, childrenhttps://www.dovepress.com/bacteriotherapy-with-streptococcus-salivarius-24smb-and-streptococcus--peer-reviewed-article-IJGMrecurrent acute otitis mediabacteriotherapyStreptococcus salivarius 24SMBStreptococcus oralis 89anasal spraychildren.
spellingShingle La Mantia I
Varricchio A
Ciprandi G
Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience
International Journal of General Medicine
recurrent acute otitis media
bacteriotherapy
Streptococcus salivarius 24SMB
Streptococcus oralis 89a
nasal spray
children.
title Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience
title_full Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience
title_fullStr Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience
title_full_unstemmed Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience
title_short Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience
title_sort bacteriotherapy with streptococcus salivarius 24smb and streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children a real life clinical experience
topic recurrent acute otitis media
bacteriotherapy
Streptococcus salivarius 24SMB
Streptococcus oralis 89a
nasal spray
children.
url https://www.dovepress.com/bacteriotherapy-with-streptococcus-salivarius-24smb-and-streptococcus--peer-reviewed-article-IJGM
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AT varricchioa bacteriotherapywithstreptococcussalivarius24smbandstreptococcusoralis89anasalsprayforpreventingrecurrentacuteotitismediainchildrenareallifeclinicalexperience
AT ciprandig bacteriotherapywithstreptococcussalivarius24smbandstreptococcusoralis89anasalsprayforpreventingrecurrentacuteotitismediainchildrenareallifeclinicalexperience