Experience of using rifapentine in continuation phase of treatment of adult tuberculosis cases
The objective of the study: to estimate efficacy and safety of the drug of rifapentine in continuation phase of chemotherapy in adults suffering from pulmonary tuberculosis.Subjects and methods. 66 HIV negative pulmonary tuberculosis patients transferred to continuation phase of treatment with regim...
| Main Authors: | , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2019-07-01
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| Series: | Туберкулез и болезни лёгких |
| Subjects: | |
| Online Access: | https://www.tibl-journal.com/jour/article/view/1288 |
| _version_ | 1797702959162720256 |
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| author | T. I. Morozova O. N. Otpuschennikova |
| author_facet | T. I. Morozova O. N. Otpuschennikova |
| author_sort | T. I. Morozova |
| collection | DOAJ |
| description | The objective of the study: to estimate efficacy and safety of the drug of rifapentine in continuation phase of chemotherapy in adults suffering from pulmonary tuberculosis.Subjects and methods. 66 HIV negative pulmonary tuberculosis patients transferred to continuation phase of treatment with regimens I and III were enrolled in a prospective randomized trial. The patients were randomly divided into 2 groups. Group I included 36 of patients who were prescribed with rifapentine at the dose of 10 mg per 1 kg of body mass, 3 of times per week, and isoniazid at the dose 10 mg per 1 kg of body mass daily. Group II included 30 of patients who were prescribed with rifampicin 450-600 mg/day (taking into account the body mass) and isoniazid, 10 mg per 1 kg of body mass daily. In continuation phase of treatment, patients from both groups received 120 doses of drugs.Results. 1. In continuation phase of chemotherapy in new pulmonary tuberculosis adult cases, the regimen consisting of rifapentine + isoniazid demonstrated the efficacy compatible with the one of the regimen consisting of rifampicin + isoniazide.2. Use of rifapentine at the dose of 10 mg/kg, 3 times a week in continuation phase of treatment did not cause an increase in adverse events compared to daily in-take of rifampicin.3. The anti-tuberculosis drug of rifapentine can successfully be used in continuation phase of chemotherapy in drug susceptible tuberculosis patients.4. The prescription of rifapentine reduces the drug burden since it can be taken 3 times a week. |
| first_indexed | 2024-03-12T04:58:29Z |
| format | Article |
| id | doaj.art-2e82e0ddd41349819706f3e632f3b37f |
| institution | Directory Open Access Journal |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| last_indexed | 2024-03-12T04:58:29Z |
| publishDate | 2019-07-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj.art-2e82e0ddd41349819706f3e632f3b37f2023-09-03T09:14:35ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062019-07-01976313510.21292/2075-1230-2019-97-6-31-351288Experience of using rifapentine in continuation phase of treatment of adult tuberculosis casesT. I. Morozova0O. N. Otpuschennikova1ФГБОУ ВО «Саратовский ГМУ им. В. И. Разумовского» МЗ РФФГБОУ ВО «Саратовский ГМУ им. В. И. Разумовского» МЗ РФThe objective of the study: to estimate efficacy and safety of the drug of rifapentine in continuation phase of chemotherapy in adults suffering from pulmonary tuberculosis.Subjects and methods. 66 HIV negative pulmonary tuberculosis patients transferred to continuation phase of treatment with regimens I and III were enrolled in a prospective randomized trial. The patients were randomly divided into 2 groups. Group I included 36 of patients who were prescribed with rifapentine at the dose of 10 mg per 1 kg of body mass, 3 of times per week, and isoniazid at the dose 10 mg per 1 kg of body mass daily. Group II included 30 of patients who were prescribed with rifampicin 450-600 mg/day (taking into account the body mass) and isoniazid, 10 mg per 1 kg of body mass daily. In continuation phase of treatment, patients from both groups received 120 doses of drugs.Results. 1. In continuation phase of chemotherapy in new pulmonary tuberculosis adult cases, the regimen consisting of rifapentine + isoniazid demonstrated the efficacy compatible with the one of the regimen consisting of rifampicin + isoniazide.2. Use of rifapentine at the dose of 10 mg/kg, 3 times a week in continuation phase of treatment did not cause an increase in adverse events compared to daily in-take of rifampicin.3. The anti-tuberculosis drug of rifapentine can successfully be used in continuation phase of chemotherapy in drug susceptible tuberculosis patients.4. The prescription of rifapentine reduces the drug burden since it can be taken 3 times a week.https://www.tibl-journal.com/jour/article/view/1288рифапентинтуберкулез легкихфаза продолжения химиотерапии |
| spellingShingle | T. I. Morozova O. N. Otpuschennikova Experience of using rifapentine in continuation phase of treatment of adult tuberculosis cases Туберкулез и болезни лёгких рифапентин туберкулез легких фаза продолжения химиотерапии |
| title | Experience of using rifapentine in continuation phase of treatment of adult tuberculosis cases |
| title_full | Experience of using rifapentine in continuation phase of treatment of adult tuberculosis cases |
| title_fullStr | Experience of using rifapentine in continuation phase of treatment of adult tuberculosis cases |
| title_full_unstemmed | Experience of using rifapentine in continuation phase of treatment of adult tuberculosis cases |
| title_short | Experience of using rifapentine in continuation phase of treatment of adult tuberculosis cases |
| title_sort | experience of using rifapentine in continuation phase of treatment of adult tuberculosis cases |
| topic | рифапентин туберкулез легких фаза продолжения химиотерапии |
| url | https://www.tibl-journal.com/jour/article/view/1288 |
| work_keys_str_mv | AT timorozova experienceofusingrifapentineincontinuationphaseoftreatmentofadulttuberculosiscases AT onotpuschennikova experienceofusingrifapentineincontinuationphaseoftreatmentofadulttuberculosiscases |