Nitric oxide — soluble guanylate cyclase — cyclic guanosine monophosphate signaling pathway in the pathogenesis of heart failure and search for novel therapeutic targets
Heart failure is a severe disease with an unfavorable prognosis, which requires intensification of therapy and the search for novel approaches to treatment. In this review, the physiological significance of soluble guanylate cyclase-related signaling pathway, reasons for decrease in its activity in...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2021-10-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/3035 |
| _version_ | 1797882312154677248 |
|---|---|
| author | Zh. D. Kobalava P. V. Lazarev |
| author_facet | Zh. D. Kobalava P. V. Lazarev |
| author_sort | Zh. D. Kobalava |
| collection | DOAJ |
| description | Heart failure is a severe disease with an unfavorable prognosis, which requires intensification of therapy and the search for novel approaches to treatment. In this review, the physiological significance of soluble guanylate cyclase-related signaling pathway, reasons for decrease in its activity in heart failure and possible consequences are discussed. Pharmacological methods of stimulating the production of cyclic guanosine monophosphate using drugs with different mechanisms of action are considered. Data from clinical studies regarding their effectiveness and safety are presented. A promising approach is stimulation of soluble guanylate cyclase, which showed beneficial effects in preclinical studies, as well as in the recently completed phase III VICTORIA study. |
| first_indexed | 2024-04-10T03:33:49Z |
| format | Article |
| id | doaj.art-2e85e34f17e94a13885fc2f90b9b87eb |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:33:49Z |
| publishDate | 2021-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-2e85e34f17e94a13885fc2f90b9b87eb2023-03-13T07:23:31Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252021-10-0120610.15829/1728-8800-2021-30352341Nitric oxide — soluble guanylate cyclase — cyclic guanosine monophosphate signaling pathway in the pathogenesis of heart failure and search for novel therapeutic targetsZh. D. Kobalava0P. V. Lazarev1ФГАОУ ВО Российский Университет Дружбы НародовБайер, АОHeart failure is a severe disease with an unfavorable prognosis, which requires intensification of therapy and the search for novel approaches to treatment. In this review, the physiological significance of soluble guanylate cyclase-related signaling pathway, reasons for decrease in its activity in heart failure and possible consequences are discussed. Pharmacological methods of stimulating the production of cyclic guanosine monophosphate using drugs with different mechanisms of action are considered. Data from clinical studies regarding their effectiveness and safety are presented. A promising approach is stimulation of soluble guanylate cyclase, which showed beneficial effects in preclinical studies, as well as in the recently completed phase III VICTORIA study.https://cardiovascular.elpub.ru/jour/article/view/3035сердечная недостаточностьгуанилатциклазасигнальный путь |
| spellingShingle | Zh. D. Kobalava P. V. Lazarev Nitric oxide — soluble guanylate cyclase — cyclic guanosine monophosphate signaling pathway in the pathogenesis of heart failure and search for novel therapeutic targets Кардиоваскулярная терапия и профилактика сердечная недостаточность гуанилатциклаза сигнальный путь |
| title | Nitric oxide — soluble guanylate cyclase — cyclic guanosine monophosphate signaling pathway in the pathogenesis of heart failure and search for novel therapeutic targets |
| title_full | Nitric oxide — soluble guanylate cyclase — cyclic guanosine monophosphate signaling pathway in the pathogenesis of heart failure and search for novel therapeutic targets |
| title_fullStr | Nitric oxide — soluble guanylate cyclase — cyclic guanosine monophosphate signaling pathway in the pathogenesis of heart failure and search for novel therapeutic targets |
| title_full_unstemmed | Nitric oxide — soluble guanylate cyclase — cyclic guanosine monophosphate signaling pathway in the pathogenesis of heart failure and search for novel therapeutic targets |
| title_short | Nitric oxide — soluble guanylate cyclase — cyclic guanosine monophosphate signaling pathway in the pathogenesis of heart failure and search for novel therapeutic targets |
| title_sort | nitric oxide soluble guanylate cyclase cyclic guanosine monophosphate signaling pathway in the pathogenesis of heart failure and search for novel therapeutic targets |
| topic | сердечная недостаточность гуанилатциклаза сигнальный путь |
| url | https://cardiovascular.elpub.ru/jour/article/view/3035 |
| work_keys_str_mv | AT zhdkobalava nitricoxidesolubleguanylatecyclasecyclicguanosinemonophosphatesignalingpathwayinthepathogenesisofheartfailureandsearchfornoveltherapeutictargets AT pvlazarev nitricoxidesolubleguanylatecyclasecyclicguanosinemonophosphatesignalingpathwayinthepathogenesisofheartfailureandsearchfornoveltherapeutictargets |