Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics

Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics

Continued methodological advances have enabled numerous statistical approaches for the analysis of summary statistics from genome-wide association studies. Genetic correlation analysis within specific regions enables a new strategy for identifying pleiotropy. Genomic regions with significant ‘local’...

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Những tác giả chính: Thomas P Spargo, Lachlan Gilchrist, Guy P Hunt, Richard JB Dobson, Petroula Proitsi, Ammar Al-Chalabi, Oliver Pain, Alfredo Iacoangeli
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: eLife Sciences Publications Ltd 2024-12-01
Loạt:eLife
Những chủ đề:
fine-mapping
neurodegenerative diseases
colocalisation
local genetic correlation
Truy cập trực tuyến:https://elifesciences.org/articles/88768

Internet

https://elifesciences.org/articles/88768

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