Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning.
Hippocampal development is thought to play a crucial role in the emergence of many forms of learning and memory, but ontogenetic changes in hippocampal activity during learning have not been examined thoroughly. We examined the ontogeny of hippocampal function by recording theta and single neuron ac...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5072650?pdf=render |
| _version_ | 1819118482641387520 |
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| author | Jangjin Kim Mary E Goldsberry Thomas C Harmon John H Freeman |
| author_facet | Jangjin Kim Mary E Goldsberry Thomas C Harmon John H Freeman |
| author_sort | Jangjin Kim |
| collection | DOAJ |
| description | Hippocampal development is thought to play a crucial role in the emergence of many forms of learning and memory, but ontogenetic changes in hippocampal activity during learning have not been examined thoroughly. We examined the ontogeny of hippocampal function by recording theta and single neuron activity from the dorsal hippocampal CA1 area while rat pups were trained in associative learning. Three different age groups [postnatal days (P)17-19, P21-23, and P24-26] were trained over six sessions using a tone conditioned stimulus (CS) and a periorbital stimulation unconditioned stimulus (US). Learning increased as a function of age, with the P21-23 and P24-26 groups learning faster than the P17-19 group. Age- and learning-related changes in both theta and single neuron activity were observed. CA1 pyramidal cells in the older age groups showed greater task-related activity than the P17-19 group during CS-US paired sessions. The proportion of trials with a significant theta (4-10 Hz) power change, the theta/delta ratio, and theta peak frequency also increased in an age-dependent manner. Finally, spike/theta phase-locking during the CS showed an age-related increase. The findings indicate substantial developmental changes in dorsal hippocampal function that may play a role in the ontogeny of learning and memory. |
| first_indexed | 2024-12-22T05:49:35Z |
| format | Article |
| id | doaj.art-2e8a14c9d1b74efea6cea689ff6eec6a |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T05:49:35Z |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2e8a14c9d1b74efea6cea689ff6eec6a2022-12-21T18:36:55ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-011110e016478110.1371/journal.pone.0164781Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning.Jangjin KimMary E GoldsberryThomas C HarmonJohn H FreemanHippocampal development is thought to play a crucial role in the emergence of many forms of learning and memory, but ontogenetic changes in hippocampal activity during learning have not been examined thoroughly. We examined the ontogeny of hippocampal function by recording theta and single neuron activity from the dorsal hippocampal CA1 area while rat pups were trained in associative learning. Three different age groups [postnatal days (P)17-19, P21-23, and P24-26] were trained over six sessions using a tone conditioned stimulus (CS) and a periorbital stimulation unconditioned stimulus (US). Learning increased as a function of age, with the P21-23 and P24-26 groups learning faster than the P17-19 group. Age- and learning-related changes in both theta and single neuron activity were observed. CA1 pyramidal cells in the older age groups showed greater task-related activity than the P17-19 group during CS-US paired sessions. The proportion of trials with a significant theta (4-10 Hz) power change, the theta/delta ratio, and theta peak frequency also increased in an age-dependent manner. Finally, spike/theta phase-locking during the CS showed an age-related increase. The findings indicate substantial developmental changes in dorsal hippocampal function that may play a role in the ontogeny of learning and memory.http://europepmc.org/articles/PMC5072650?pdf=render |
| spellingShingle | Jangjin Kim Mary E Goldsberry Thomas C Harmon John H Freeman Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning. PLoS ONE |
| title | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning. |
| title_full | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning. |
| title_fullStr | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning. |
| title_full_unstemmed | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning. |
| title_short | Developmental Changes in Hippocampal CA1 Single Neuron Firing and Theta Activity during Associative Learning. |
| title_sort | developmental changes in hippocampal ca1 single neuron firing and theta activity during associative learning |
| url | http://europepmc.org/articles/PMC5072650?pdf=render |
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