Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouch
Abstract Our aim was to explore the correlation between ultrasound attenuation parameter (UAP) and liver stiffness measurement (LSM) based on FibroTouch (China) and clinical features in patients with non-alcoholic fatty liver disease (NAFLD), so as to provide a certain basis for the clinical applica...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-41596-2 |
| _version_ | 1797452834963193856 |
|---|---|
| author | Yan Liao Lei Liu Jiayao Yang Xiaoli Zhou Xiaoli Teng Yixi Li Ying Wan Jian Yang Zhaohong Shi |
| author_facet | Yan Liao Lei Liu Jiayao Yang Xiaoli Zhou Xiaoli Teng Yixi Li Ying Wan Jian Yang Zhaohong Shi |
| author_sort | Yan Liao |
| collection | DOAJ |
| description | Abstract Our aim was to explore the correlation between ultrasound attenuation parameter (UAP) and liver stiffness measurement (LSM) based on FibroTouch (China) and clinical features in patients with non-alcoholic fatty liver disease (NAFLD), so as to provide a certain basis for the clinical application of FibroTouch in NAFLD. Hepatic steatosis and fibrosis in patients with NAFLD were graded according to FibroTouch, and the relationship between steatosis and fibrosis levels and clinical characteristics was retrospectively analyzed. Hepatic steatosis was positively related with weight, BMI, waist, hyperlipidemia, hyperuricemia, FBG, UA, TG, ALT, AST, GGT, LSM and hepatic fibrosis grading, and was negatively related with gender (male), age and AST/ALT ratio. Hepatic fibrosis was positively related with age, BMI, waist, hypertension, FBG, ALT, AST, GGT, NFS, APRI, FIB-4, UAP and hepatic steatosis grading, and was negatively related with blood platelet (PLT) counts. Moreover, BMI, waist, TG, ALT and LSM were independent risk factors of hepatic steatosis, while decreased PLT counts, AST and UAP were independent risk factors of hepatic fibrosis. Body mass parameters, metabolic risk factors and liver function indicators increase the risk of hepatic steatosis and fibrosis in patients with NAFLD, and UAP and LSM can interact with each other. |
| first_indexed | 2024-03-09T15:14:24Z |
| format | Article |
| id | doaj.art-2e8d8fb3a6aa4c6d927ffecc16334c07 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:14:24Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-2e8d8fb3a6aa4c6d927ffecc16334c072023-11-26T13:09:00ZengNature PortfolioScientific Reports2045-23222023-09-0113111110.1038/s41598-023-41596-2Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouchYan Liao0Lei Liu1Jiayao Yang2Xiaoli Zhou3Xiaoli Teng4Yixi Li5Ying Wan6Jian Yang7Zhaohong Shi8Department of GastroenterologyDepartment of Pancreatic Surgery, Renmin Hospital of Wuhan UniversityDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyDepartment of GastroenterologyAbstract Our aim was to explore the correlation between ultrasound attenuation parameter (UAP) and liver stiffness measurement (LSM) based on FibroTouch (China) and clinical features in patients with non-alcoholic fatty liver disease (NAFLD), so as to provide a certain basis for the clinical application of FibroTouch in NAFLD. Hepatic steatosis and fibrosis in patients with NAFLD were graded according to FibroTouch, and the relationship between steatosis and fibrosis levels and clinical characteristics was retrospectively analyzed. Hepatic steatosis was positively related with weight, BMI, waist, hyperlipidemia, hyperuricemia, FBG, UA, TG, ALT, AST, GGT, LSM and hepatic fibrosis grading, and was negatively related with gender (male), age and AST/ALT ratio. Hepatic fibrosis was positively related with age, BMI, waist, hypertension, FBG, ALT, AST, GGT, NFS, APRI, FIB-4, UAP and hepatic steatosis grading, and was negatively related with blood platelet (PLT) counts. Moreover, BMI, waist, TG, ALT and LSM were independent risk factors of hepatic steatosis, while decreased PLT counts, AST and UAP were independent risk factors of hepatic fibrosis. Body mass parameters, metabolic risk factors and liver function indicators increase the risk of hepatic steatosis and fibrosis in patients with NAFLD, and UAP and LSM can interact with each other.https://doi.org/10.1038/s41598-023-41596-2 |
| spellingShingle | Yan Liao Lei Liu Jiayao Yang Xiaoli Zhou Xiaoli Teng Yixi Li Ying Wan Jian Yang Zhaohong Shi Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouch Scientific Reports |
| title | Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouch |
| title_full | Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouch |
| title_fullStr | Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouch |
| title_full_unstemmed | Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouch |
| title_short | Analysis of clinical features and identification of risk factors in patients with non-alcoholic fatty liver disease based on FibroTouch |
| title_sort | analysis of clinical features and identification of risk factors in patients with non alcoholic fatty liver disease based on fibrotouch |
| url | https://doi.org/10.1038/s41598-023-41596-2 |
| work_keys_str_mv | AT yanliao analysisofclinicalfeaturesandidentificationofriskfactorsinpatientswithnonalcoholicfattyliverdiseasebasedonfibrotouch AT leiliu analysisofclinicalfeaturesandidentificationofriskfactorsinpatientswithnonalcoholicfattyliverdiseasebasedonfibrotouch AT jiayaoyang analysisofclinicalfeaturesandidentificationofriskfactorsinpatientswithnonalcoholicfattyliverdiseasebasedonfibrotouch AT xiaolizhou analysisofclinicalfeaturesandidentificationofriskfactorsinpatientswithnonalcoholicfattyliverdiseasebasedonfibrotouch AT xiaoliteng analysisofclinicalfeaturesandidentificationofriskfactorsinpatientswithnonalcoholicfattyliverdiseasebasedonfibrotouch AT yixili analysisofclinicalfeaturesandidentificationofriskfactorsinpatientswithnonalcoholicfattyliverdiseasebasedonfibrotouch AT yingwan analysisofclinicalfeaturesandidentificationofriskfactorsinpatientswithnonalcoholicfattyliverdiseasebasedonfibrotouch AT jianyang analysisofclinicalfeaturesandidentificationofriskfactorsinpatientswithnonalcoholicfattyliverdiseasebasedonfibrotouch AT zhaohongshi analysisofclinicalfeaturesandidentificationofriskfactorsinpatientswithnonalcoholicfattyliverdiseasebasedonfibrotouch |