Use of antibiotics after lower third molar surgery - useful or harmful procedure? A randomized, double-blind, placebo-controlled trial
Introduction/Objective. The aim of the present study was to investigate the effects of moxifloxacin and cefixime in preventing postoperative infection following mandibular third molar surgery. Methods. Double-blind study was completed by 157 patients undergoing surgical removal of mandibular third m...
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| Format: | Article |
| Language: | English |
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Serbian Medical Society
2022-01-01
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| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2022/0370-81792200049S.pdf |
| _version_ | 1818050149417484288 |
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| author | Stošić Branimir Šarčev Ivan Mirković Siniša Medić Deana Novaković Milica Soldatović Ivan Bajkin Branislav |
| author_facet | Stošić Branimir Šarčev Ivan Mirković Siniša Medić Deana Novaković Milica Soldatović Ivan Bajkin Branislav |
| author_sort | Stošić Branimir |
| collection | DOAJ |
| description | Introduction/Objective. The aim of the present study was to investigate the effects of moxifloxacin and cefixime in preventing postoperative infection following mandibular third molar surgery. Methods. Double-blind study was completed by 157 patients undergoing surgical removal of mandibular third molars. The patients were randomly assigned to the following three groups: moxifloxacin (M), cefixime (C), and placebo (P). Patients in each group were classified into two subgroups: subgroup (a), without previous history of pericoronitis, and subgroup (b), with previous history of pericoronitis. All the patients were evaluated at the postoperative follow-ups on the first, second, and seventh postoperative day. Results. Postoperative infections were registered only in patients with a history of pericoronitis. Antibiotic prophylaxis with cefixime and moxifloxacin reduced the occurrence of postoperative infection. Overall incidence of postoperative infections was 6.4%. All postoperative infections were registered in the placebogroup, where the incidence of postoperative infection was 19.2%. Microbiological tests verified the clinically obtained results. Isolated microflora was resistant to penicillin-derived antibiotics in 50% of the cases. Conclusion. Prophylactic use of antibiotics after third molar surgery should be weighed against potential risks and benefits and could be considered in cases with previous history of pericoronitis, when complicated surgical extraction is performed. |
| first_indexed | 2024-12-10T10:48:53Z |
| format | Article |
| id | doaj.art-2e8e7a16a5ba4e968be37785e9f1cb2c |
| institution | Directory Open Access Journal |
| issn | 0370-8179 2406-0895 |
| language | English |
| last_indexed | 2024-12-10T10:48:53Z |
| publishDate | 2022-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-2e8e7a16a5ba4e968be37785e9f1cb2c2022-12-22T01:52:04ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792406-08952022-01-011507-840741310.2298/SARH220124049S0370-81792200049SUse of antibiotics after lower third molar surgery - useful or harmful procedure? A randomized, double-blind, placebo-controlled trialStošić Branimir0https://orcid.org/0000-0001-8459-0201Šarčev Ivan1Mirković Siniša2Medić Deana3Novaković Milica4Soldatović Ivan5https://orcid.org/0000-0003-4893-1683Bajkin Branislav6https://orcid.org/0000-0003-2189-6769University of Novi Sad, Faculty of Medicine, Dental Clinic of Vojvodina, Department of Oral Surgery, Novi Sad, Serbia + Dr. Draga Ljočić Health Center, Šabac, Serbia + University of Travnik, Faculty of Pharmacy and Health, Travnik, Federation of Bosnia and Herzegovina, Bosnia and HerzegovinaUniversity of Novi Sad, Faculty of Medicine, Dental Clinic of Vojvodina, Department of Oral Surgery, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Dental Clinic of Vojvodina, Department of Oral Surgery, Novi Sad, SerbiaUniversity of Novi Sad, Faculty of Medicine, Institute of Public Health of Vojvodina, Center for Microbiology, Department of Bacteriology, Novi Sad, Serbia + University of Novi Sad, Faculty of Medicine, Department of Microbiology with Parasitology and Immunology, Novi Sad, SerbiaUniversity of Belgrade, School of Dental Medicine, Belgrade, SerbiaUniversity of Belgrade, Faculty of Medicine, Institute of Medical Statistics and Informatics, Belgrade, SerbiaUniversity of Novi Sad, Faculty of Medicine, Dental Clinic of Vojvodina, Department of Oral Surgery, Novi Sad, SerbiaIntroduction/Objective. The aim of the present study was to investigate the effects of moxifloxacin and cefixime in preventing postoperative infection following mandibular third molar surgery. Methods. Double-blind study was completed by 157 patients undergoing surgical removal of mandibular third molars. The patients were randomly assigned to the following three groups: moxifloxacin (M), cefixime (C), and placebo (P). Patients in each group were classified into two subgroups: subgroup (a), without previous history of pericoronitis, and subgroup (b), with previous history of pericoronitis. All the patients were evaluated at the postoperative follow-ups on the first, second, and seventh postoperative day. Results. Postoperative infections were registered only in patients with a history of pericoronitis. Antibiotic prophylaxis with cefixime and moxifloxacin reduced the occurrence of postoperative infection. Overall incidence of postoperative infections was 6.4%. All postoperative infections were registered in the placebogroup, where the incidence of postoperative infection was 19.2%. Microbiological tests verified the clinically obtained results. Isolated microflora was resistant to penicillin-derived antibiotics in 50% of the cases. Conclusion. Prophylactic use of antibiotics after third molar surgery should be weighed against potential risks and benefits and could be considered in cases with previous history of pericoronitis, when complicated surgical extraction is performed.http://www.doiserbia.nb.rs/img/doi/0370-8179/2022/0370-81792200049S.pdfthird molar surgeryantibiotic prophylaxispostoperative complicationsdrug resistancemicrobial susceptibility tests |
| spellingShingle | Stošić Branimir Šarčev Ivan Mirković Siniša Medić Deana Novaković Milica Soldatović Ivan Bajkin Branislav Use of antibiotics after lower third molar surgery - useful or harmful procedure? A randomized, double-blind, placebo-controlled trial Srpski Arhiv za Celokupno Lekarstvo third molar surgery antibiotic prophylaxis postoperative complications drug resistance microbial susceptibility tests |
| title | Use of antibiotics after lower third molar surgery - useful or harmful procedure? A randomized, double-blind, placebo-controlled trial |
| title_full | Use of antibiotics after lower third molar surgery - useful or harmful procedure? A randomized, double-blind, placebo-controlled trial |
| title_fullStr | Use of antibiotics after lower third molar surgery - useful or harmful procedure? A randomized, double-blind, placebo-controlled trial |
| title_full_unstemmed | Use of antibiotics after lower third molar surgery - useful or harmful procedure? A randomized, double-blind, placebo-controlled trial |
| title_short | Use of antibiotics after lower third molar surgery - useful or harmful procedure? A randomized, double-blind, placebo-controlled trial |
| title_sort | use of antibiotics after lower third molar surgery useful or harmful procedure a randomized double blind placebo controlled trial |
| topic | third molar surgery antibiotic prophylaxis postoperative complications drug resistance microbial susceptibility tests |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2022/0370-81792200049S.pdf |
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