The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species
It has become apparent that hydrogen sulfide (H2S), hydropersulfides (RSSH) and other polysulfide species are all intimately linked biochemically. Indeed, at least some of the biological activity attributed to hydrogen sulfide (H2S) may actually be due to its conversion to RSSH and derived polysulfu...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-11-01
|
| Series: | Redox Biology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231722002580 |
| _version_ | 1811257492129185792 |
|---|---|
| author | Christopher H. Switzer Jon M. Fukuto |
| author_facet | Christopher H. Switzer Jon M. Fukuto |
| author_sort | Christopher H. Switzer |
| collection | DOAJ |
| description | It has become apparent that hydrogen sulfide (H2S), hydropersulfides (RSSH) and other polysulfide species are all intimately linked biochemically. Indeed, at least some of the biological activity attributed to hydrogen sulfide (H2S) may actually be due to its conversion to RSSH and derived polysulfur species (and vice-versa). The unique chemistry associated with the hydropersulfide functional group (-SSH) predicts that it possesses possible protective properties that can help a cell contend with oxidative and/or electrophilic stress. However, since RSSH and polysulfides possess chemical properties akin to disulfides (RSSR), they can also be sources of oxidative/electrophilic stress/signaling as well. Herein are discussed the unique chemistry, possible biochemistry and the physiological implications of RSSH (and polysulfides), especially as it pertains to their putative cellular protection properties against a variety of stresses and/or as possible stressors/signaling agents themselves. |
| first_indexed | 2024-04-12T17:58:18Z |
| format | Article |
| id | doaj.art-2e8e952974144880b7383db052ab21ac |
| institution | Directory Open Access Journal |
| issn | 2213-2317 |
| language | English |
| last_indexed | 2024-04-12T17:58:18Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Redox Biology |
| spelling | doaj.art-2e8e952974144880b7383db052ab21ac2022-12-22T03:22:16ZengElsevierRedox Biology2213-23172022-11-0157102486The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide speciesChristopher H. Switzer0Jon M. Fukuto1William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UKDepartment of Chemistry, Johns Hopkins University, Baltimore, MD, 21218, USA; Department of Chemistry, Sonoma State University, Rohnert Park, CA, 94928, USA; Corresponding author. Department of Chemistry, Johns Hopkins University, Baltimore, MD, 21218, USA.It has become apparent that hydrogen sulfide (H2S), hydropersulfides (RSSH) and other polysulfide species are all intimately linked biochemically. Indeed, at least some of the biological activity attributed to hydrogen sulfide (H2S) may actually be due to its conversion to RSSH and derived polysulfur species (and vice-versa). The unique chemistry associated with the hydropersulfide functional group (-SSH) predicts that it possesses possible protective properties that can help a cell contend with oxidative and/or electrophilic stress. However, since RSSH and polysulfides possess chemical properties akin to disulfides (RSSR), they can also be sources of oxidative/electrophilic stress/signaling as well. Herein are discussed the unique chemistry, possible biochemistry and the physiological implications of RSSH (and polysulfides), especially as it pertains to their putative cellular protection properties against a variety of stresses and/or as possible stressors/signaling agents themselves.http://www.sciencedirect.com/science/article/pii/S2213231722002580Hydrogen sulfideHydropersulfidesPolysulfidesS-nitrosothiol |
| spellingShingle | Christopher H. Switzer Jon M. Fukuto The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species Redox Biology Hydrogen sulfide Hydropersulfides Polysulfides S-nitrosothiol |
| title | The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species |
| title_full | The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species |
| title_fullStr | The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species |
| title_full_unstemmed | The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species |
| title_short | The antioxidant and oxidant properties of hydropersulfides (RSSH) and polysulfide species |
| title_sort | antioxidant and oxidant properties of hydropersulfides rssh and polysulfide species |
| topic | Hydrogen sulfide Hydropersulfides Polysulfides S-nitrosothiol |
| url | http://www.sciencedirect.com/science/article/pii/S2213231722002580 |
| work_keys_str_mv | AT christopherhswitzer theantioxidantandoxidantpropertiesofhydropersulfidesrsshandpolysulfidespecies AT jonmfukuto theantioxidantandoxidantpropertiesofhydropersulfidesrsshandpolysulfidespecies AT christopherhswitzer antioxidantandoxidantpropertiesofhydropersulfidesrsshandpolysulfidespecies AT jonmfukuto antioxidantandoxidantpropertiesofhydropersulfidesrsshandpolysulfidespecies |