Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges
Interest in the study of gene–environment interaction has recently grown due to the sudden availability of molecular genetic data—in particular, polygenic scores—in many long-running longitudinal studies. Identifying and estimating statistical interactions comes with several analytic and inferential...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Society for Sociological Science
2020-09-01
|
| Series: | Sociological Science |
| Subjects: | |
| Online Access: | https://sociologicalscience.com/articles-v7-19-465/ |
| _version_ | 1818561875849248768 |
|---|---|
| author | Benjamin W. Domingue Sam Trejo Emma Armstrong-Carter Elliot M. Tucker-Drob |
| author_facet | Benjamin W. Domingue Sam Trejo Emma Armstrong-Carter Elliot M. Tucker-Drob |
| author_sort | Benjamin W. Domingue |
| collection | DOAJ |
| description | Interest in the study of gene–environment interaction has recently grown due to the sudden availability of molecular genetic data—in particular, polygenic scores—in many long-running longitudinal studies. Identifying and estimating statistical interactions comes with several analytic and inferential challenges; these challenges are heightened when used to integrate observational genomic and social science data. We articulate some of these key challenges, provide new perspectives on the study of gene–environment interactions, and end by offering some practical guidance for conducting research in this area. Given the sudden availability of well-powered polygenic scores, we anticipate a substantial increase in research testing for interaction between such scores and environments. The issues we discuss, if not properly addressed, may impact the enduring scientific value of gene–environment interaction studies. |
| first_indexed | 2024-12-14T00:56:26Z |
| format | Article |
| id | doaj.art-2e8f62092a9449f2b30354c6febcb7db |
| institution | Directory Open Access Journal |
| issn | 2330-6696 2330-6696 |
| language | English |
| last_indexed | 2024-12-14T00:56:26Z |
| publishDate | 2020-09-01 |
| publisher | Society for Sociological Science |
| record_format | Article |
| series | Sociological Science |
| spelling | doaj.art-2e8f62092a9449f2b30354c6febcb7db2022-12-21T23:23:31ZengSociety for Sociological ScienceSociological Science2330-66962330-66962020-09-0171936538610.15195/v7.a19Interactions between Polygenic Scores and Environments: Methodological and Conceptual ChallengesBenjamin W. Domingue0Sam Trejo1Emma Armstrong-Carter2Elliot M. Tucker-Drob3Stanford UniversityUniversity of Wisconsin–MadisonStanford UniversityUniversity of Texas at AustinInterest in the study of gene–environment interaction has recently grown due to the sudden availability of molecular genetic data—in particular, polygenic scores—in many long-running longitudinal studies. Identifying and estimating statistical interactions comes with several analytic and inferential challenges; these challenges are heightened when used to integrate observational genomic and social science data. We articulate some of these key challenges, provide new perspectives on the study of gene–environment interactions, and end by offering some practical guidance for conducting research in this area. Given the sudden availability of well-powered polygenic scores, we anticipate a substantial increase in research testing for interaction between such scores and environments. The issues we discuss, if not properly addressed, may impact the enduring scientific value of gene–environment interaction studies.https://sociologicalscience.com/articles-v7-19-465/polygenic scoregene–environment interaction |
| spellingShingle | Benjamin W. Domingue Sam Trejo Emma Armstrong-Carter Elliot M. Tucker-Drob Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges Sociological Science polygenic score gene–environment interaction |
| title | Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges |
| title_full | Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges |
| title_fullStr | Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges |
| title_full_unstemmed | Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges |
| title_short | Interactions between Polygenic Scores and Environments: Methodological and Conceptual Challenges |
| title_sort | interactions between polygenic scores and environments methodological and conceptual challenges |
| topic | polygenic score gene–environment interaction |
| url | https://sociologicalscience.com/articles-v7-19-465/ |
| work_keys_str_mv | AT benjaminwdomingue interactionsbetweenpolygenicscoresandenvironmentsmethodologicalandconceptualchallenges AT samtrejo interactionsbetweenpolygenicscoresandenvironmentsmethodologicalandconceptualchallenges AT emmaarmstrongcarter interactionsbetweenpolygenicscoresandenvironmentsmethodologicalandconceptualchallenges AT elliotmtuckerdrob interactionsbetweenpolygenicscoresandenvironmentsmethodologicalandconceptualchallenges |