Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitus
BackgroundCarotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. The miRNA-29c was reported to promote the phenotype transforma...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1276066/full |
| _version_ | 1827357811982467072 |
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| author | Hua Wang Hua Wang Peipei Mai Fang He Yanfang Zhang |
| author_facet | Hua Wang Hua Wang Peipei Mai Fang He Yanfang Zhang |
| author_sort | Hua Wang |
| collection | DOAJ |
| description | BackgroundCarotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. The miRNA-29c was reported to promote the phenotype transformation of vascular smooth muscle cells (VSMCs) in diabetes mice, eventually leading to plaque formation and bleeding. However, such studies are rare and limited to animal experiments.MethodsIn our study, 40 patients were divided into a diabetic mellitus (DM) group and a non-DM group according to whether they were diagnosed with DM. Then, the real-time quantitative PCR was applied to examine the miRNA-29c level in human carotid plaque tissue derived from 40 subjects receiving carotid endarterectomy.ResultsBriefly, diabetes patients had a decreased miRNA-29c level as compared with non-DM subjects, and this comparison was statistically significant (P = 0.02). Notably, variable miRNA-29c level was negatively associated with HbA1c level, although no statistical significance was observed. Moreover, there was an increased miRNA-29c level in patients with cerebral stroke.ConclusionCollectively, the miRNA-29c level in the carotid plaque is closely associated with DM and cerebral stroke, which may contribute to atherosclerosis formation. |
| first_indexed | 2024-03-08T05:53:24Z |
| format | Article |
| id | doaj.art-2e8fe9c2ce784e939ee9388875d3d675 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-08T05:53:24Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-2e8fe9c2ce784e939ee9388875d3d6752024-02-05T04:58:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-02-011110.3389/fcvm.2024.12760661276066Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitusHua Wang0Hua Wang1Peipei Mai2Fang He3Yanfang Zhang4Division of Graduate, Xinxiang Medical University, Xinxiang, Henan, ChinaDepartment of Ultrasonography, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, ChinaDepartment of Ultrasonography, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, ChinaDivision of Graduate, Xinxiang Medical University, Xinxiang, Henan, ChinaDepartment of Endocrinology, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang, ChinaBackgroundCarotid artery atherosclerosis is a major cause of ischemic stroke, and ischemic stroke is the leading cause of morbidity and mortality worldwide. Unfortunately, the reason for the build-up of atherosclerosis plaque is unknown. The miRNA-29c was reported to promote the phenotype transformation of vascular smooth muscle cells (VSMCs) in diabetes mice, eventually leading to plaque formation and bleeding. However, such studies are rare and limited to animal experiments.MethodsIn our study, 40 patients were divided into a diabetic mellitus (DM) group and a non-DM group according to whether they were diagnosed with DM. Then, the real-time quantitative PCR was applied to examine the miRNA-29c level in human carotid plaque tissue derived from 40 subjects receiving carotid endarterectomy.ResultsBriefly, diabetes patients had a decreased miRNA-29c level as compared with non-DM subjects, and this comparison was statistically significant (P = 0.02). Notably, variable miRNA-29c level was negatively associated with HbA1c level, although no statistical significance was observed. Moreover, there was an increased miRNA-29c level in patients with cerebral stroke.ConclusionCollectively, the miRNA-29c level in the carotid plaque is closely associated with DM and cerebral stroke, which may contribute to atherosclerosis formation.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1276066/fullmiRNA-29cplaque vulnerabilitydiabetic mellitusvascular smooth muscle cellsVSMC |
| spellingShingle | Hua Wang Hua Wang Peipei Mai Fang He Yanfang Zhang Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitus Frontiers in Cardiovascular Medicine miRNA-29c plaque vulnerability diabetic mellitus vascular smooth muscle cells VSMC |
| title | Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitus |
| title_full | Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitus |
| title_fullStr | Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitus |
| title_full_unstemmed | Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitus |
| title_short | Expression of miRNA-29c in the carotid plaque and its association with diabetic mellitus |
| title_sort | expression of mirna 29c in the carotid plaque and its association with diabetic mellitus |
| topic | miRNA-29c plaque vulnerability diabetic mellitus vascular smooth muscle cells VSMC |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1276066/full |
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