Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men
Physical activity (PA) has been shown to associate with many health benefits but studies with metabolome-wide associations with PA are still lacking. Metabolome studies may deepen the mechanistic understanding of PA on the metabolic pathways related to health outcomes. The aim of the present study w...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/12/8/700 |
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| author | Jani P. Vaara Heikki Kyröläinen Tommi Vasankari Heikki Kainulainen Jani Raitanen Urho M Kujala |
| author_facet | Jani P. Vaara Heikki Kyröläinen Tommi Vasankari Heikki Kainulainen Jani Raitanen Urho M Kujala |
| author_sort | Jani P. Vaara |
| collection | DOAJ |
| description | Physical activity (PA) has been shown to associate with many health benefits but studies with metabolome-wide associations with PA are still lacking. Metabolome studies may deepen the mechanistic understanding of PA on the metabolic pathways related to health outcomes. The aim of the present study was to study the association of accelerometer based sedentary time (SB) and PA with metabolome measures. SB and PA were measured by a hip-worn accelerometer in 314 young adult men (age: mean 28, standard deviation 7 years). Metabolome was analyzed from fasting serum samples consisting of 66 metabolome measures (nuclear magnetic resonance-based metabolomics). The associations were analyzed using a single and compositional approach with regression analysis. The compositional analysis revealed that 4 metabolome variables were significantly (γ: 0.32–0.44, <i>p</i> ≤ 0.002), and 13 variables with a trend towards significance (<i>p</i> < 0.05), associated with SB with varying metabolic pathways. Trends towards significant associations (<i>p</i> < 0.05) were observed with 5 variables with moderate-to-vigorous and 1 variable with light intensity PA with varying metabolic pathways. The present study revealed possible mechanistic pathways relevant for the interaction between especially SB but also PA of moderate-to-vigorous intensity with ketone bodies and amino acid concentration related to exercised-induced energy production and lipid metabolism. |
| first_indexed | 2024-03-09T09:52:38Z |
| format | Article |
| id | doaj.art-2e91a7ce9eb5416faa8286bca9cd024a |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T09:52:38Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-2e91a7ce9eb5416faa8286bca9cd024a2023-12-02T00:00:14ZengMDPI AGMetabolites2218-19892022-07-0112870010.3390/metabo12080700Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young MenJani P. Vaara0Heikki Kyröläinen1Tommi Vasankari2Heikki Kainulainen3Jani Raitanen4Urho M Kujala5Department of Leadership and Military Pedagogy, National Defence University, 00861 Helsinki, FinlandFaculty of Sport and Health Science, University of Jyväskylä, 40014 Jyväskylän, FinlandUKK-Institute for Health Promotion Research, 33500 Tampere, FinlandFaculty of Sport and Health Science, University of Jyväskylä, 40014 Jyväskylän, FinlandUKK-Institute for Health Promotion Research, 33500 Tampere, FinlandFaculty of Sport and Health Science, University of Jyväskylä, 40014 Jyväskylän, FinlandPhysical activity (PA) has been shown to associate with many health benefits but studies with metabolome-wide associations with PA are still lacking. Metabolome studies may deepen the mechanistic understanding of PA on the metabolic pathways related to health outcomes. The aim of the present study was to study the association of accelerometer based sedentary time (SB) and PA with metabolome measures. SB and PA were measured by a hip-worn accelerometer in 314 young adult men (age: mean 28, standard deviation 7 years). Metabolome was analyzed from fasting serum samples consisting of 66 metabolome measures (nuclear magnetic resonance-based metabolomics). The associations were analyzed using a single and compositional approach with regression analysis. The compositional analysis revealed that 4 metabolome variables were significantly (γ: 0.32–0.44, <i>p</i> ≤ 0.002), and 13 variables with a trend towards significance (<i>p</i> < 0.05), associated with SB with varying metabolic pathways. Trends towards significant associations (<i>p</i> < 0.05) were observed with 5 variables with moderate-to-vigorous and 1 variable with light intensity PA with varying metabolic pathways. The present study revealed possible mechanistic pathways relevant for the interaction between especially SB but also PA of moderate-to-vigorous intensity with ketone bodies and amino acid concentration related to exercised-induced energy production and lipid metabolism.https://www.mdpi.com/2218-1989/12/8/700objective physical activitysedentary timebody compositionmetabolomicscardiovascular risk factors |
| spellingShingle | Jani P. Vaara Heikki Kyröläinen Tommi Vasankari Heikki Kainulainen Jani Raitanen Urho M Kujala Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men Metabolites objective physical activity sedentary time body composition metabolomics cardiovascular risk factors |
| title | Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men |
| title_full | Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men |
| title_fullStr | Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men |
| title_full_unstemmed | Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men |
| title_short | Accelerometer-Based Sedentary Time, Physical Activity, and Serum Metabolome in Young Men |
| title_sort | accelerometer based sedentary time physical activity and serum metabolome in young men |
| topic | objective physical activity sedentary time body composition metabolomics cardiovascular risk factors |
| url | https://www.mdpi.com/2218-1989/12/8/700 |
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