The role of B cells in COVID-19 infection and vaccination
B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SAR...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.988536/full |
| _version_ | 1828121696819740672 |
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| author | Shiru Chen Shiru Chen Fei Guan Fabio Candotti Kamel Benlagha Niels Olsen Saraiva Camara Andres A. Herrada Louisa K. James Jiahui Lei Heather Miller Masato Kubo Qin Ning Chaohong Liu |
| author_facet | Shiru Chen Shiru Chen Fei Guan Fabio Candotti Kamel Benlagha Niels Olsen Saraiva Camara Andres A. Herrada Louisa K. James Jiahui Lei Heather Miller Masato Kubo Qin Ning Chaohong Liu |
| author_sort | Shiru Chen |
| collection | DOAJ |
| description | B cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations. |
| first_indexed | 2024-04-11T14:24:10Z |
| format | Article |
| id | doaj.art-2e91db76813647e8b8fa138b1dc2533b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T14:24:10Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-2e91db76813647e8b8fa138b1dc2533b2022-12-22T04:18:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.988536988536The role of B cells in COVID-19 infection and vaccinationShiru Chen0Shiru Chen1Fei Guan2Fabio Candotti3Kamel Benlagha4Niels Olsen Saraiva Camara5Andres A. Herrada6Louisa K. James7Jiahui Lei8Heather Miller9Masato Kubo10Qin Ning11Chaohong Liu12Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, ChinaDepartment of Internal Medicine, The Division of Gastroenterology and Hepatology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, ChinaDivision of Immunology and Allergy, Lausanne University Hospital and University of Lausanne, Lausanne, SwitzerlandInstitut de Recherche Saint-Louis, Université de Paris, Paris, FranceLaboratory of Human Immunology, Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, BrazilLymphatic and Inflammation Research Laboratory, Facultad de Ciencias de la Salud, Instituto de Ciencias Biomedicas, Universidad Autonoma de Chile, Talca, ChileCentre for Immunobiology, Bizard Institute, Queen Mary University of London, London, United KingdomDepartment of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, ChinaCytek Biosciences, R&D Clinical Reagents, Fremont, CA, United StatesLaboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), Rikagaku Kenkyusho, Institute of Physical and Chemical Research (RIKEN) Yokohama Institute, Yokohama, Kanagawa, Japan0Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science Technology, Wuhan, ChinaB cells secrete antibodies and mediate the humoral immune response, making them extremely important in protective immunity against SARS-CoV-2, which caused the coronavirus disease 2019 (COVID-19) pandemic. In this review, we summarize the positive function and pathological response of B cells in SARS-CoV-2 infection and re-infection. Then, we structure the immunity responses that B cells mediated in peripheral tissues. Furthermore, we discuss the role of B cells during vaccination including the effectiveness of antibodies and memory B cells, viral evolution mechanisms, and future vaccine development. This review might help medical workers and researchers to have a better understanding of the interaction between B cells and SARS-CoV-2 and broaden their vision for future investigations.https://www.frontiersin.org/articles/10.3389/fimmu.2022.988536/fullB cellsantibodyCOVID-19SARS-CoV-2memory B cellsvaccination |
| spellingShingle | Shiru Chen Shiru Chen Fei Guan Fabio Candotti Kamel Benlagha Niels Olsen Saraiva Camara Andres A. Herrada Louisa K. James Jiahui Lei Heather Miller Masato Kubo Qin Ning Chaohong Liu The role of B cells in COVID-19 infection and vaccination Frontiers in Immunology B cells antibody COVID-19 SARS-CoV-2 memory B cells vaccination |
| title | The role of B cells in COVID-19 infection and vaccination |
| title_full | The role of B cells in COVID-19 infection and vaccination |
| title_fullStr | The role of B cells in COVID-19 infection and vaccination |
| title_full_unstemmed | The role of B cells in COVID-19 infection and vaccination |
| title_short | The role of B cells in COVID-19 infection and vaccination |
| title_sort | role of b cells in covid 19 infection and vaccination |
| topic | B cells antibody COVID-19 SARS-CoV-2 memory B cells vaccination |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.988536/full |
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