CYP2C19 Contributes to THP-1-Cell-Derived M2 Macrophage Polarization by Producing 11,12- and 14,15-Epoxyeicosatrienoic Acid, Agonists of the PPARγ Receptor

CYP2C19 Contributes to THP-1-Cell-Derived M2 Macrophage Polarization by Producing 11,12- and 14,15-Epoxyeicosatrienoic Acid, Agonists of the PPARγ Receptor

Although the functional roles of M1 and M2 macrophages in the immune response and drug resistance are important, the expression and role of cytochrome P450s (CYPs) in these cells remain largely unknown. Differential expression of the 12 most common CYPs (CYP1A1, 1A2, 1B1, 2B6, 2C8, 2C9, 2C19, 2D6, 2...

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Bibliographic Details
Main Authors: Hee Young Cho, Sangzin Ahn, Yong-Soon Cho, Su-Kil Seo, Dong Hyun Kim, Jae-Gook Shin, Su-Jun Lee
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceuticals
Subjects:
cytochrome P450
CYP2C19
M2 macrophage
metabolism
PPAR gamma
EETs
Online Access:https://www.mdpi.com/1424-8247/16/4/593

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